Sort by
Items per page

Send to

Choose Destination

Links from PubMed

Items: 1 to 20 of 287


Sphingosine kinase 1 regulates the Akt/FOXO3a/Bim pathway and contributes to apoptosis resistance in glioma cells.

Guan H, Song L, Cai J, Huang Y, Wu J, Yuan J, Li J, Li M.

PLoS One. 2011;6(5):e19946. doi: 10.1371/journal.pone.0019946. Epub 2011 May 18.


SphK1 confers resistance to apoptosis in gastric cancer cells by downregulating Bim via stimulating Akt/FoxO3a signaling.

Xiong H, Wang J, Guan H, Wu J, Xu R, Wang M, Rong X, Huang K, Huang J, Liao Q, Fu Y, Yuan J.

Oncol Rep. 2014 Oct;32(4):1369-73. doi: 10.3892/or.2014.3391. Epub 2014 Aug 7.


FoxO proteins' nuclear retention and BH3-only protein Bim induction evoke mitochondrial dysfunction-mediated apoptosis in berberine-treated HepG2 cells.

Shukla S, Rizvi F, Raisuddin S, Kakkar P.

Free Radic Biol Med. 2014 Nov;76:185-99. doi: 10.1016/j.freeradbiomed.2014.07.039. Epub 2014 Aug 13.


The HSP90 inhibitor XL888 overcomes BRAF inhibitor resistance mediated through diverse mechanisms.

Paraiso KH, Haarberg HE, Wood E, Rebecca VW, Chen YA, Xiang Y, Ribas A, Lo RS, Weber JS, Sondak VK, John JK, Sarnaik AA, Koomen JM, Smalley KS.

Clin Cancer Res. 2012 May 1;18(9):2502-14. doi: 10.1158/1078-0432.CCR-11-2612. Epub 2012 Feb 20.


18β-glycyrrhetinic acid induces apoptosis through modulation of Akt/FOXO3a/Bim pathway in human breast cancer MCF-7 cells.

Sharma G, Kar S, Palit S, Das PK.

J Cell Physiol. 2012 May;227(5):1923-31. doi: 10.1002/jcp.22920.


BIM-mediated AKT phosphorylation is a key modulator of arsenic trioxide-induced apoptosis in cisplatin-sensitive and -resistant ovarian cancer cells.

Yuan Z, Wang F, Zhao Z, Zhao X, Qiu J, Nie C, Wei Y.

PLoS One. 2011;6(5):e20586. doi: 10.1371/journal.pone.0020586. Epub 2011 May 31.


PTEN-regulated AKT/FoxO3a/Bim signaling contributes to reactive oxygen species-mediated apoptosis in selenite-treated colorectal cancer cells.

Luo H, Yang Y, Duan J, Wu P, Jiang Q, Xu C.

Cell Death Dis. 2013 Feb 7;4:e481. doi: 10.1038/cddis.2013.3.


Involvement of the PTEN-AKT-FOXO3a pathway in neuronal apoptosis in developing rat brain after hypoxia-ischemia.

Li D, Qu Y, Mao M, Zhang X, Li J, Ferriero D, Mu D.

J Cereb Blood Flow Metab. 2009 Dec;29(12):1903-13. doi: 10.1038/jcbfm.2009.102. Epub 2009 Jul 22.


8‑bromo‑7‑methoxychrysin induces apoptosis by regulating Akt/FOXO3a pathway in cisplatin‑sensitive and resistant ovarian cancer cells.

Ding Q, Chen Y, Zhang Q, Guo Y, Huang Z, Dai L, Cao S.

Mol Med Rep. 2015 Oct;12(4):5100-8. doi: 10.3892/mmr.2015.4039. Epub 2015 Jul 3.


FoxO3a is activated and executes neuron death via Bim in response to β-amyloid.

Sanphui P, Biswas SC.

Cell Death Dis. 2013 May 9;4:e625. doi: 10.1038/cddis.2013.148.


Selenium sensitizes MCF-7 breast cancer cells to doxorubicin-induced apoptosis through modulation of phospho-Akt and its downstream substrates.

Li S, Zhou Y, Wang R, Zhang H, Dong Y, Ip C.

Mol Cancer Ther. 2007 Mar;6(3):1031-8. Epub 2007 Mar 5.


Sphingosine kinase-1 enhances resistance to apoptosis through activation of PI3K/Akt/NF-κB pathway in human non-small cell lung cancer.

Song L, Xiong H, Li J, Liao W, Wang L, Wu J, Li M.

Clin Cancer Res. 2011 Apr 1;17(7):1839-49. doi: 10.1158/1078-0432.CCR-10-0720. Epub 2011 Feb 15.


Follicle-stimulating hormone regulates pro-apoptotic protein Bcl-2-interacting mediator of cell death-extra long (BimEL)-induced porcine granulosa cell apoptosis.

Wang XL, Wu Y, Tan LB, Tian Z, Liu JH, Zhu DS, Zeng SM.

J Biol Chem. 2012 Mar 23;287(13):10166-77. doi: 10.1074/jbc.M111.293274. Epub 2012 Jan 10.


Dual inhibition of Bcl-2 and Bcl-xL strikingly enhances PI3K inhibition-induced apoptosis in human myeloid leukemia cells through a GSK3- and Bim-dependent mechanism.

Rahmani M, Aust MM, Attkisson E, Williams DC Jr, Ferreira-Gonzalez A, Grant S.

Cancer Res. 2013 Feb 15;73(4):1340-51. doi: 10.1158/0008-5472.CAN-12-1365. Epub 2012 Dec 12.


High glucose induced oxidative stress and apoptosis in cardiac microvascular endothelial cells are regulated by FoxO3a.

Peng C, Ma J, Gao X, Tian P, Li W, Zhang L.

PLoS One. 2013 Nov 18;8(11):e79739. doi: 10.1371/journal.pone.0079739. eCollection 2013.


Melatonin induces transcriptional regulation of Bim by FoxO3a in HepG2 cells.

Carbajo-Pescador S, Steinmetz C, Kashyap A, Lorenz S, Mauriz JL, Heise M, Galle PR, González-Gallego J, Strand S.

Br J Cancer. 2013 Feb 5;108(2):442-9. doi: 10.1038/bjc.2012.563. Epub 2012 Dec 20.


CHOP potentially co-operates with FOXO3a in neuronal cells to regulate PUMA and BIM expression in response to ER stress.

Ghosh AP, Klocke BJ, Ballestas ME, Roth KA.

PLoS One. 2012;7(6):e39586. doi: 10.1371/journal.pone.0039586. Epub 2012 Jun 28.


FOXO3a reactivation mediates the synergistic cytotoxic effects of rapamycin and cisplatin in oral squamous cell carcinoma cells.

Fang L, Wang H, Zhou L, Yu D.

Toxicol Appl Pharmacol. 2011 Feb 15;251(1):8-15. doi: 10.1016/j.taap.2010.11.007. Epub 2010 Nov 16.


Apoptosis induction by MEK inhibition in human lung cancer cells is mediated by Bim.

Meng J, Fang B, Liao Y, Chresta CM, Smith PD, Roth JA.

PLoS One. 2010 Sep 27;5(9):e13026. doi: 10.1371/journal.pone.0013026.


BH3-only protein Bim more critical than Puma in tyrosine kinase inhibitor-induced apoptosis of human leukemic cells and transduced hematopoietic progenitors carrying oncogenic FLT3.

Nordigården A, Kraft M, Eliasson P, Labi V, Lam EW, Villunger A, Jönsson JI.

Blood. 2009 Mar 5;113(10):2302-11. doi: 10.1182/blood-2008-07-167023. Epub 2008 Dec 8.

Supplemental Content

Support Center