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Items: 1 to 20 of 82

1.

Enhanced glycoprotein production in HEK-293 cells expressing pyruvate carboxylase.

Henry O, Durocher Y.

Metab Eng. 2011 Sep;13(5):499-507. doi: 10.1016/j.ymben.2011.05.004. Epub 2011 May 23.

PMID:
21624497
3.

Exploiting the metabolism of PYC expressing HEK293 cells in fed-batch cultures.

Vallée C, Durocher Y, Henry O.

J Biotechnol. 2014 Jan;169:63-70. doi: 10.1016/j.jbiotec.2013.11.002. Epub 2013 Nov 15.

PMID:
24246270
4.

Metabolic engineering of CHO cells to alter lactate metabolism during fed-batch cultures.

Toussaint C, Henry O, Durocher Y.

J Biotechnol. 2016 Jan 10;217:122-31. doi: 10.1016/j.jbiotec.2015.11.010. Epub 2015 Nov 18.

5.

Altering the central carbon metabolism of HEK293 cells: Impact on recombinant glycoprotein quality.

Karengera E, Robotham A, Kelly J, Durocher Y, De Crescenzo G, Henry O.

J Biotechnol. 2017 Jan 20;242:73-82. doi: 10.1016/j.jbiotec.2016.12.003. Epub 2016 Dec 7.

PMID:
27940295
6.

Improving glucose and glutamine metabolism of human HEK 293 and Trichoplusia ni insect cells engineered to express a cytosolic pyruvate carboxylase enzyme.

Elias CB, Carpentier E, Durocher Y, Bisson L, Wagner R, Kamen A.

Biotechnol Prog. 2003 Jan-Feb;19(1):90-7.

PMID:
12573011
9.

Improvement of the primary metabolism of cell cultures by introducing a new cytoplasmic pyruvate carboxylase reaction.

Irani N, Wirth M, van Den Heuvel J, Wagner R.

Biotechnol Bioeng. 1999;66(4):238-46.

PMID:
10578094
10.

Enhanced alpha-ketoglutaric acid production in Yarrowia lipolytica WSH-Z06 by regulation of the pyruvate carboxylation pathway.

Yin X, Madzak C, Du G, Zhou J, Chen J.

Appl Microbiol Biotechnol. 2012 Dec;96(6):1527-37. doi: 10.1007/s00253-012-4192-z. Epub 2012 Jun 9.

PMID:
22678027
11.

Unraveling the metabolism of HEK-293 cells using lactate isotopomer analysis.

Henry O, Jolicoeur M, Kamen A.

Bioprocess Biosyst Eng. 2011 Mar;34(3):263-73. doi: 10.1007/s00449-010-0468-9. Epub 2010 Sep 17.

PMID:
20848294
12.

Yeast pyruvate carboxylase: identification of two genes encoding isoenzymes.

Walker ME, Val DL, Rohde M, Devenish RJ, Wallace JC.

Biochem Biophys Res Commun. 1991 May 15;176(3):1210-7.

PMID:
2039506
13.

Impact of temperature reduction and expression of yeast pyruvate carboxylase on hGM-CSF-producing CHO cells.

Fogolín MB, Wagner R, Etcheverrigaray M, Kratje R.

J Biotechnol. 2004 Apr 8;109(1-2):179-91.

PMID:
15063626
14.

Development of valuable yeast strains using a novel mutagenesis technique for the effective production of therapeutic glycoproteins.

Abe H, Takaoka Y, Chiba Y, Sato N, Ohgiya S, Itadani A, Hirashima M, Shimoda C, Jigami Y, Nakayama K.

Glycobiology. 2009 Apr;19(4):428-36. doi: 10.1093/glycob/cwn157. Epub 2009 Jan 7.

PMID:
19129247
15.

Regulation of pyc1 encoding pyruvate carboxylase isozyme I by nitrogen sources in Saccharomyces cerevisiae.

Huet C, Menendez J, Gancedo C, François JM.

Eur J Biochem. 2000 Dec;267(23):6817-23.

17.

Physiological characterisation of a pyruvate-carboxylase-negative Saccharomyces cerevisiae mutant in batch and chemostat cultures.

de Jong-Gubbels P, Bauer J, Niederberger P, Stückrath I, Kötter P, van Dijken JP, Pronk JT.

Antonie Van Leeuwenhoek. 1998 Nov;74(4):253-63.

PMID:
10081585
18.

Double mutation of the PDC1 and ADH1 genes improves lactate production in the yeast Saccharomyces cerevisiae expressing the bovine lactate dehydrogenase gene.

Tokuhiro K, Ishida N, Nagamori E, Saitoh S, Onishi T, Kondo A, Takahashi H.

Appl Microbiol Biotechnol. 2009 Apr;82(5):883-90. doi: 10.1007/s00253-008-1831-5. Epub 2009 Jan 3.

PMID:
19122995
19.
20.

Pyruvate carboxylase in the yeast pyc mutant.

Lim F, Rohde M, Morris CP, Wallace JC.

Arch Biochem Biophys. 1987 Oct;258(1):259-64.

PMID:
3116940

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