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Items: 1 to 20 of 95


The relationship between fibrogenic TGFβ1 signaling in the joint and cartilage degradation in post-injury osteoarthritis.

Plaas A, Velasco J, Gorski DJ, Li J, Cole A, Christopherson K, Sandy JD.

Osteoarthritis Cartilage. 2011 Sep;19(9):1081-90. doi: 10.1016/j.joca.2011.05.003. Epub 2011 May 17. Review.


Deletion of the transforming growth factor β receptor type II gene in articular chondrocytes leads to a progressive osteoarthritis-like phenotype in mice.

Shen J, Li J, Wang B, Jin H, Wang M, Zhang Y, Yang Y, Im HJ, O'Keefe R, Chen D.

Arthritis Rheum. 2013 Dec;65(12):3107-19. doi: 10.1002/art.38122.


Adamts5 deletion blocks murine dermal repair through CD44-mediated aggrecan accumulation and modulation of transforming growth factor β1 (TGFβ1) signaling.

Velasco J, Li J, DiPietro L, Stepp MA, Sandy JD, Plaas A.

J Biol Chem. 2011 Jul 22;286(29):26016-27. doi: 10.1074/jbc.M110.208694. Epub 2011 May 12.


Hyaluronan injection in murine osteoarthritis prevents TGFbeta 1-induced synovial neovascularization and fibrosis and maintains articular cartilage integrity by a CD44-dependent mechanism.

Li J, Gorski DJ, Anemaet W, Velasco J, Takeuchi J, Sandy JD, Plaas A.

Arthritis Res Ther. 2012 Jun 21;14(3):R151. doi: 10.1186/ar3887.


Age-related alterations in TGF beta signaling as a causal factor of cartilage degeneration in osteoarthritis.

van der Kraan PM.

Biomed Mater Eng. 2014;24(1 Suppl):75-80. doi: 10.3233/BME-140976.


Aggrecanolysis in human osteoarthritis: confocal localization and biochemical characterization of ADAMTS5-hyaluronan complexes in articular cartilages.

Plaas A, Osborn B, Yoshihara Y, Bai Y, Bloom T, Nelson F, Mikecz K, Sandy JD.

Osteoarthritis Cartilage. 2007 Jul;15(7):719-34. Epub 2007 Mar 23.


Increase in ALK1/ALK5 ratio as a cause for elevated MMP-13 expression in osteoarthritis in humans and mice.

Blaney Davidson EN, Remst DF, Vitters EL, van Beuningen HM, Blom AB, Goumans MJ, van den Berg WB, van der Kraan PM.

J Immunol. 2009 Jun 15;182(12):7937-45. doi: 10.4049/jimmunol.0803991. Erratum in: J Immunol. 2010 Aug 15;185(4):2629.


The Regulatory Role of Signaling Crosstalk in Hypertrophy of MSCs and Human Articular Chondrocytes.

Zhong L, Huang X, Karperien M, Post JN.

Int J Mol Sci. 2015 Aug 14;16(8):19225-47. doi: 10.3390/ijms160819225. Review.


Modulating hedgehog signaling can attenuate the severity of osteoarthritis.

Lin AC, Seeto BL, Bartoszko JM, Khoury MA, Whetstone H, Ho L, Hsu C, Ali SA, Alman BA.

Nat Med. 2009 Dec;15(12):1421-5. doi: 10.1038/nm.2055. Epub 2009 Nov 15. Erratum in: Nat Med. 2010 Jan;16(1):129. Ali, Amanda S [corrected to Ali, S Amanda].


Protective effect of lentivirus-mediated siRNA targeting ADAMTS-5 on cartilage degradation in a rat model of osteoarthritis.

Chu X, You H, Yuan X, Zhao W, Li W, Guo X.

Int J Mol Med. 2013 May;31(5):1222-8. doi: 10.3892/ijmm.2013.1318. Epub 2013 Mar 26.


Reduction in disease progression by inhibition of transforming growth factor α-CCL2 signaling in experimental posttraumatic osteoarthritis.

Appleton CT, Usmani SE, Pest MA, Pitelka V, Mort JS, Beier F.

Arthritis Rheumatol. 2015 Oct;67(10):2691-701. doi: 10.1002/art.39255.


MicroRNA-140 is expressed in differentiated human articular chondrocytes and modulates interleukin-1 responses.

Miyaki S, Nakasa T, Otsuki S, Grogan SP, Higashiyama R, Inoue A, Kato Y, Sato T, Lotz MK, Asahara H.

Arthritis Rheum. 2009 Sep;60(9):2723-30. doi: 10.1002/art.24745.


Evidence for a key role of leptin in osteoarthritis.

Dumond H, Presle N, Terlain B, Mainard D, Loeuille D, Netter P, Pottie P.

Arthritis Rheum. 2003 Nov;48(11):3118-29.


Extracellular sulfatases support cartilage homeostasis by regulating BMP and FGF signaling pathways.

Otsuki S, Hanson SR, Miyaki S, Grogan SP, Kinoshita M, Asahara H, Wong CH, Lotz MK.

Proc Natl Acad Sci U S A. 2010 Jun 1;107(22):10202-7. doi: 10.1073/pnas.0913897107. Epub 2010 May 17.


ADAM-12 (meltrin alpha) is involved in chondrocyte proliferation via cleavage of insulin-like growth factor binding protein 5 in osteoarthritic cartilage.

Okada A, Mochizuki S, Yatabe T, Kimura T, Shiomi T, Fujita Y, Matsumoto H, Sehara-Fujisawa A, Iwamoto Y, Okada Y.

Arthritis Rheum. 2008 Mar;58(3):778-89. doi: 10.1002/art.23262.


Protein kinase Czeta is up-regulated in osteoarthritic cartilage and is required for activation of NF-kappaB by tumor necrosis factor and interleukin-1 in articular chondrocytes.

LaVallie ER, Chockalingam PS, Collins-Racie LA, Freeman BA, Keohan CC, Leitges M, Dorner AJ, Morris EA, Majumdar MK, Arai M.

J Biol Chem. 2006 Aug 25;281(34):24124-37. Epub 2006 Jun 23.


Fibroblast growth factor receptor 1 is principally responsible for fibroblast growth factor 2-induced catabolic activities in human articular chondrocytes.

Yan D, Chen D, Cool SM, van Wijnen AJ, Mikecz K, Murphy G, Im HJ.

Arthritis Res Ther. 2011 Aug 11;13(4):R130. doi: 10.1186/ar3441.


Inhibition of Rac1 activity by controlled release of NSC23766 from chitosan microspheres effectively ameliorates osteoarthritis development in vivo.

Zhu S, Lu P, Liu H, Chen P, Wu Y, Wang Y, Sun H, Zhang X, Xia Q, Heng BC, Zhou Y, Ouyang HW.

Ann Rheum Dis. 2015 Jan;74(1):285-93. doi: 10.1136/annrheumdis-2013-203901. Epub 2013 Nov 20.


Enhancement of the synthesis of n-3 PUFAs in fat-1 transgenic mice inhibits mTORC1 signalling and delays surgically induced osteoarthritis in comparison with wild-type mice.

Huang MJ, Wang L, Jin DD, Zhang ZM, Chen TY, Jia CH, Wang Y, Zhen XC, Huang B, Yan B, Chen YH, Li SF, Yang JC, Dai YF, Bai XC.

Ann Rheum Dis. 2014 Sep;73(9):1719-27. doi: 10.1136/annrheumdis-2013-203231. Epub 2013 Jul 12.


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