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Items: 1 to 20 of 140

1.

Increasing dihydrobiopterin causes dysfunction of endothelial nitric oxide synthase in rats in vivo.

Noguchi K, Hamadate N, Matsuzaki T, Sakanashi M, Nakasone J, Uchida T, Arakaki K, Kubota H, Ishiuchi S, Masuzaki H, Sugahara K, Ohya Y, Sakanashi M, Tsutsui M.

Am J Physiol Heart Circ Physiol. 2011 Sep;301(3):H721-9. doi: 10.1152/ajpheart.01089.2010.

2.

Caloric restriction reverses high-fat diet-induced endothelial dysfunction and vascular superoxide production in C57Bl/6 mice.

Ketonen J, Pilvi T, Mervaala E.

Heart Vessels. 2010 May;25(3):254-62. doi: 10.1007/s00380-009-1182-x.

PMID:
20512454
3.

Nitric oxide dynamics and endothelial dysfunction in type II model of genetic diabetes.

Bitar MS, Wahid S, Mustafa S, Al-Saleh E, Dhaunsi GS, Al-Mulla F.

Eur J Pharmacol. 2005 Mar 21;511(1):53-64.

PMID:
15777779
4.

Activation of PPAR╬┤ prevents endothelial dysfunction induced by overexpression of amyloid-╬▓ precursor protein.

d'Uscio LV, Das P, Santhanam AV, He T, Younkin SG, Katusic ZS.

Cardiovasc Res. 2012 Dec 1;96(3):504-12. doi: 10.1093/cvr/cvs266.

5.

eNOS uncoupling and endothelial dysfunction in aged vessels.

Yang YM, Huang A, Kaley G, Sun D.

Am J Physiol Heart Circ Physiol. 2009 Nov;297(5):H1829-36. doi: 10.1152/ajpheart.00230.2009.

6.

Ratio of 5,6,7,8-tetrahydrobiopterin to 7,8-dihydrobiopterin in endothelial cells determines glucose-elicited changes in NO vs. superoxide production by eNOS.

Crabtree MJ, Smith CL, Lam G, Goligorsky MS, Gross SS.

Am J Physiol Heart Circ Physiol. 2008 Apr;294(4):H1530-40. doi: 10.1152/ajpheart.00823.2007. Erratum in: Am J Physiol Heart Circ Physiol. 2010 Aug;299(2):H576.

7.

Vascular oxidative stress and nitric oxide depletion in HIV-1 transgenic rats are reversed by glutathione restoration.

Kline ER, Kleinhenz DJ, Liang B, Dikalov S, Guidot DM, Hart CM, Jones DP, Sutliff RL.

Am J Physiol Heart Circ Physiol. 2008 Jun;294(6):H2792-804. doi: 10.1152/ajpheart.91447.2007.

8.
9.

Cell type-specific recycling of tetrahydrobiopterin by dihydrofolate reductase explains differential effects of 7,8-dihydrobiopterin on endothelial nitric oxide synthase uncoupling.

Schmidt K, Kolesnik B, Gorren AC, Werner ER, Mayer B.

Biochem Pharmacol. 2014 Aug 1;90(3):246-53. doi: 10.1016/j.bcp.2014.05.010.

10.

Endothelial regulation of vasomotion in apoE-deficient mice: implications for interactions between peroxynitrite and tetrahydrobiopterin.

Laursen JB, Somers M, Kurz S, McCann L, Warnholtz A, Freeman BA, Tarpey M, Fukai T, Harrison DG.

Circulation. 2001 Mar 6;103(9):1282-8.

11.

Tetrahydrobiopterin deficiency and nitric oxide synthase uncoupling contribute to atherosclerosis induced by disturbed flow.

Li L, Chen W, Rezvan A, Jo H, Harrison DG.

Arterioscler Thromb Vasc Biol. 2011 Jul;31(7):1547-54. doi: 10.1161/ATVBAHA.111.226456.

13.

Arginase inhibition restores NOS coupling and reverses endothelial dysfunction and vascular stiffness in old rats.

Kim JH, Bugaj LJ, Oh YJ, Bivalacqua TJ, Ryoo S, Soucy KG, Santhanam L, Webb A, Camara A, Sikka G, Nyhan D, Shoukas AA, Ilies M, Christianson DW, Champion HC, Berkowitz DE.

J Appl Physiol (1985). 2009 Oct;107(4):1249-57. doi: 10.1152/japplphysiol.91393.2008.

14.

Abnormal biopterin metabolism is a major cause of impaired endothelium-dependent relaxation through nitric oxide/O2- imbalance in insulin-resistant rat aorta.

Shinozaki K, Kashiwagi A, Nishio Y, Okamura T, Yoshida Y, Masada M, Toda N, Kikkawa R.

Diabetes. 1999 Dec;48(12):2437-45.

PMID:
10580434
15.

Modeling of biopterin-dependent pathways of eNOS for nitric oxide and superoxide production.

Kar S, Kavdia M.

Free Radic Biol Med. 2011 Oct 1;51(7):1411-27. doi: 10.1016/j.freeradbiomed.2011.06.009.

16.

Propofol protects against high glucose-induced endothelial dysfunction in human umbilical vein endothelial cells.

Zhu M, Chen J, Tan Z, Wang J.

Anesth Analg. 2012 Feb;114(2):303-9. doi: 10.1213/ANE.0b013e31823f0c42.

PMID:
22156331
17.

Human endothelial dihydrofolate reductase low activity limits vascular tetrahydrobiopterin recycling.

Whitsett J, Rangel Filho A, Sethumadhavan S, Celinska J, Widlansky M, Vasquez-Vivar J.

Free Radic Biol Med. 2013 Oct;63:143-50. doi: 10.1016/j.freeradbiomed.2013.04.035.

18.

Activation of the PDK-1/Akt/eNOS pathway involved in aortic endothelial function differs between hyperinsulinemic and insulin-deficient diabetic rats.

Kobayashi T, Taguchi K, Nemoto S, Nogami T, Matsumoto T, Kamata K.

Am J Physiol Heart Circ Physiol. 2009 Nov;297(5):H1767-75. doi: 10.1152/ajpheart.00536.2009.

19.

Myocardial ischemia results in tetrahydrobiopterin (BH4) oxidation with impaired endothelial function ameliorated by BH4.

Dumitrescu C, Biondi R, Xia Y, Cardounel AJ, Druhan LJ, Ambrosio G, Zweier JL.

Proc Natl Acad Sci U S A. 2007 Sep 18;104(38):15081-6.

20.
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