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Acute joint pathology and synovial inflammation is associated with increased intra-articular fracture severity in the mouse knee.

Lewis JS, Hembree WC, Furman BD, Tippets L, Cattel D, Huebner JL, Little D, DeFrate LE, Kraus VB, Guilak F, Olson SA.

Osteoarthritis Cartilage. 2011 Jul;19(7):864-73. doi: 10.1016/j.joca.2011.04.011. Epub 2011 May 12.


Targeting pro-inflammatory cytokines following joint injury: acute intra-articular inhibition of interleukin-1 following knee injury prevents post-traumatic arthritis.

Furman BD, Mangiapani DS, Zeitler E, Bailey KN, Horne PH, Huebner JL, Kraus VB, Guilak F, Olson SA.

Arthritis Res Ther. 2014 Jun 25;16(3):R134. doi: 10.1186/ar4591.


Distribution and progression of chondrocyte damage in a whole-organ model of human ankle intra-articular fracture.

Tochigi Y, Buckwalter JA, Martin JA, Hillis SL, Zhang P, Vaseenon T, Lehman AD, Brown TD.

J Bone Joint Surg Am. 2011 Mar 16;93(6):533-9. doi: 10.2106/JBJS.I.01777.


Articular ankle fracture results in increased synovitis, synovial macrophage infiltration, and synovial fluid concentrations of inflammatory cytokines and chemokines.

Furman BD, Kimmerling KA, Zura RD, Reilly RM, Zlowodzki MP, Huebner JL, Kraus VB, Guilak F, Olson SA.

Arthritis Rheumatol. 2015 May;67(5):1234-9. doi: 10.1002/art.39064.


Diet-induced obesity significantly increases the severity of posttraumatic arthritis in mice.

Louer CR, Furman BD, Huebner JL, Kraus VB, Olson SA, Guilak F.

Arthritis Rheum. 2012 Oct;64(10):3220-30. doi: 10.1002/art.34533.


Therapeutic opportunities to prevent post-traumatic arthritis: Lessons from the natural history of arthritis after articular fracture.

Olson SA, Furman BD, Kraus VB, Huebner JL, Guilak F.

J Orthop Res. 2015 Sep;33(9):1266-77. doi: 10.1002/jor.22940. Epub 2015 Jun 7.


Joint degeneration following closed intraarticular fracture in the mouse knee: a model of posttraumatic arthritis.

Furman BD, Strand J, Hembree WC, Ward BD, Guilak F, Olson SA.

J Orthop Res. 2007 May;25(5):578-92.


Inflammatory Cytokines and Matrix Metalloproteinases in the Synovial Fluid After Intra-articular Ankle Fracture.

Adams SB, Setton LA, Bell RD, Easley ME, Huebner JL, Stabler T, Kraus VB, Leimer EM, Olson SA, Nettles DL.

Foot Ankle Int. 2015 Nov;36(11):1264-71. doi: 10.1177/1071100715611176. Epub 2015 Oct 8.


Early response of mouse joint tissue to noninvasive knee injury suggests treatment targets.

Wu P, Holguin N, Silva MJ, Fu M, Liao W, Sandell LJ.

Arthritis Rheumatol. 2014 May;66(5):1256-65. doi: 10.1002/art.38375.


Transforming growth factor-beta 1 stimulates articular chondrocyte proteoglycan synthesis and induces osteophyte formation in the murine knee joint.

van Beuningen HM, van der Kraan PM, Arntz OJ, van den Berg WB.

Lab Invest. 1994 Aug;71(2):279-90.


Effect of tibial plateau fracture on lubrication function and composition of synovial fluid.

Ballard BL, Antonacci JM, Temple-Wong MM, Hui AY, Schumacher BL, Bugbee WD, Schwartz AK, Girard PJ, Sah RL.

J Bone Joint Surg Am. 2012 May 16;94(10):e64. doi: 10.2106/JBJS.K.00046.


Effects of cartilage impact with and without fracture on chondrocyte viability and the release of inflammatory markers.

Stolberg-Stolberg JA, Furman BD, Garrigues NW, Lee J, Pisetsky DS, Stearns NA, DeFrate LE, Guilak F, Olson SA.

J Orthop Res. 2013 Aug;31(8):1283-92. doi: 10.1002/jor.22348. Epub 2013 Apr 25.


BMP-7 inhibits cartilage degeneration through suppression of inflammation in rat zymosan-induced arthritis.

Takahashi T, Muneta T, Tsuji K, Sekiya I.

Cell Tissue Res. 2011 May;344(2):321-32. doi: 10.1007/s00441-011-1154-1. Epub 2011 Apr 12.


Genetic and cellular evidence of decreased inflammation associated with reduced incidence of posttraumatic arthritis in MRL/MpJ mice.

Lewis JS Jr, Furman BD, Zeitler E, Huebner JL, Kraus VB, Guilak F, Olson SA.

Arthritis Rheum. 2013 Mar;65(3):660-70. doi: 10.1002/art.37796.


Structural associations of symptomatic knee osteoarthritis.

Stoppiello LA, Mapp PI, Wilson D, Hill R, Scammell BE, Walsh DA.

Arthritis Rheumatol. 2014 Nov;66(11):3018-27. doi: 10.1002/art.38778.


Deficiency of hyaluronan synthase 1 (Has1) results in chronic joint inflammation and widespread intra-articular fibrosis in a murine model of knee joint cartilage damage.

Chan DD, Xiao WF, Li J, de la Motte CA, Sandy JD, Plaas A.

Osteoarthritis Cartilage. 2015 Nov;23(11):1879-89. doi: 10.1016/j.joca.2015.06.021.


The effect of early hyaluronic acid delivery on the development of an acute articular cartilage lesion in a sheep model.

Kaplan LD, Lu Y, Snitzer J, Nemke B, Hao Z, Biro S, Albiero W, Stampfli HF, Markel M, Popkin C, Baum SZ.

Am J Sports Med. 2009 Dec;37(12):2323-7. doi: 10.1177/0363546509339579. Epub 2009 Aug 31.


Local IL-13 gene transfer prior to immune-complex arthritis inhibits chondrocyte death and matrix-metalloproteinase-mediated cartilage matrix degradation despite enhanced joint inflammation.

Nabbe KC, van Lent PL, Holthuysen AE, Sloƫtjes AW, Koch AE, Radstake TR, van den Berg WB.

Arthritis Res Ther. 2005;7(2):R392-401. Epub 2005 Jan 26.


Scavenger receptor class A type I/II determines matrix metalloproteinase-mediated cartilage destruction and chondrocyte death in antigen-induced arthritis.

van Lent PL, Hofkens W, Blom AB, Grevers L, Sloetjes A, Takahashi N, van Tits LJ, Vogl T, Roth J, de Winther MP, van den Berg WB.

Arthritis Rheum. 2009 Oct;60(10):2954-65. doi: 10.1002/art.24908.

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