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Cyclin-dependent kinase 5 activator p25 is generated during memory formation and is reduced at an early stage in Alzheimer's disease.

Engmann O, Hortobágyi T, Thompson AJ, Guadagno J, Troakes C, Soriano S, Al-Sarraj S, Kim Y, Giese KP.

Biol Psychiatry. 2011 Jul 15;70(2):159-68. doi: 10.1016/j.biopsych.2011.04.011. Epub 2011 May 26.


Is there a role of the cyclin-dependent kinase 5 activator p25 in Alzheimer's disease?

Giese KP, Ris L, Plattner F.

Neuroreport. 2005 Nov 7;16(16):1725-30. Review.


Improved reversal learning and altered fear conditioning in transgenic mice with regionally restricted p25 expression.

Angelo M, Plattner F, Irvine EE, Giese KP.

Eur J Neurosci. 2003 Jul;18(2):423-31.


Sexual dimorphisms in the effect of low-level p25 expression on synaptic plasticity and memory.

Ris L, Angelo M, Plattner F, Capron B, Errington ML, Bliss TV, Godaux E, Giese KP.

Eur J Neurosci. 2005 Jun;21(11):3023-33.


p35/p25 is not essential for tau and cytoskeletal pathology or neuronal loss in Niemann-Pick type C disease.

Hallows JL, Iosif RE, Biasell RD, Vincent I.

J Neurosci. 2006 Mar 8;26(10):2738-44.


Spatial learning impairment, enhanced CDK5/p35 activity, and downregulation of NMDA receptor expression in transgenic mice expressing tau-tubulin kinase 1.

Sato S, Xu J, Okuyama S, Martinez LB, Walsh SM, Jacobsen MT, Swan RJ, Schlautman JD, Ciborowski P, Ikezu T.

J Neurosci. 2008 Dec 31;28(53):14511-21. doi: 10.1523/JNEUROSCI.3417-08.2008.


Schizophrenia is associated with dysregulation of a Cdk5 activator that regulates synaptic protein expression and cognition.

Engmann O, Hortobágyi T, Pidsley R, Troakes C, Bernstein HG, Kreutz MR, Mill J, Nikolic M, Giese KP.

Brain. 2011 Aug;134(Pt 8):2408-21. doi: 10.1093/brain/awr155. Epub 2011 Jul 19.


Hypoxia increases Aβ-induced tau phosphorylation by calpain and promotes behavioral consequences in AD transgenic mice.

Gao L, Tian S, Gao H, Xu Y.

J Mol Neurosci. 2013 Sep;51(1):138-47. doi: 10.1007/s12031-013-9966-y. Epub 2013 Jan 24.


Generation of the Cdk5 activator p25 is a memory mechanism that is affected in early Alzheimer's disease.

Giese KP.

Front Mol Neurosci. 2014 May 1;7:36. doi: 10.3389/fnmol.2014.00036. eCollection 2014. Review.


Activity-dependent p25 generation regulates synaptic plasticity and Aβ-induced cognitive impairment.

Seo J, Giusti-Rodríguez P, Zhou Y, Rudenko A, Cho S, Ota KT, Park C, Patzke H, Madabhushi R, Pan L, Mungenast AE, Guan JS, Delalle I, Tsai LH.

Cell. 2014 Apr 10;157(2):486-98. doi: 10.1016/j.cell.2014.01.065.


Involvement of cyclin dependent kinase5 activator p25 on tau phosphorylation in mouse brain.

Takashima A, Murayama M, Yasutake K, Takahashi H, Yokoyama M, Ishiguro K.

Neurosci Lett. 2001 Jun 22;306(1-2):37-40.


Evidence that the presynaptic vesicle protein CSPalpha is a key player in synaptic degeneration and protection in Alzheimer's disease.

Tiwari SS, d'Orange M, Troakes C, Shurovi BN, Engmann O, Noble W, Hortobágyi T, Giese KP.

Mol Brain. 2015 Jan 29;8:6. doi: 10.1186/s13041-015-0096-z.


A survey of Cdk5 activator p35 and p25 levels in Alzheimer's disease brains.

Tseng HC, Zhou Y, Shen Y, Tsai LH.

FEBS Lett. 2002 Jul 17;523(1-3):58-62.


Opposing roles of transient and prolonged expression of p25 in synaptic plasticity and hippocampus-dependent memory.

Fischer A, Sananbenesi F, Pang PT, Lu B, Tsai LH.

Neuron. 2005 Dec 8;48(5):825-38.


Modulation of p25 and inflammatory pathways by fisetin maintains cognitive function in Alzheimer's disease transgenic mice.

Currais A, Prior M, Dargusch R, Armando A, Ehren J, Schubert D, Quehenberger O, Maher P.

Aging Cell. 2014 Apr;13(2):379-90. doi: 10.1111/acel.12185. Epub 2013 Dec 17.


Calpain-mediated degradation of p35 to p25 in postmortem human and rat brains.

Taniguchi S, Fujita Y, Hayashi S, Kakita A, Takahashi H, Murayama S, Saido TC, Hisanaga S, Iwatsubo T, Hasegawa M.

FEBS Lett. 2001 Jan 26;489(1):46-50.


Expression of p25 impairs contextual learning but not latent inhibition in mice.

Mizuno K, Plattner F, Peter Giese K.

Neuroreport. 2006 Dec 18;17(18):1903-5.


Reduced Reelin expression accelerates amyloid-beta plaque formation and tau pathology in transgenic Alzheimer's disease mice.

Kocherhans S, Madhusudan A, Doehner J, Breu KS, Nitsch RM, Fritschy JM, Knuesel I.

J Neurosci. 2010 Jul 7;30(27):9228-40. doi: 10.1523/JNEUROSCI.0418-10.2010.


Calpastatin, an endogenous calpain-inhibitor protein, regulates the cleavage of the Cdk5 activator p35 to p25.

Sato K, Minegishi S, Takano J, Plattner F, Saito T, Asada A, Kawahara H, Iwata N, Saido TC, Hisanaga S.

J Neurochem. 2011 May;117(3):504-15. doi: 10.1111/j.1471-4159.2011.07222.x. Epub 2011 Mar 15.


Cdk5/p25-induced cytosolic PLA2-mediated lysophosphatidylcholine production regulates neuroinflammation and triggers neurodegeneration.

Sundaram JR, Chan ES, Poore CP, Pareek TK, Cheong WF, Shui G, Tang N, Low CM, Wenk MR, Kesavapany S.

J Neurosci. 2012 Jan 18;32(3):1020-34. doi: 10.1523/JNEUROSCI.5177-11.2012.

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