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Items: 1 to 20 of 107

1.

Evaluation of a ricin vaccine candidate (RVEc) for human toxicity using an in vitro vascular leak assay.

Porter A, Phillips G, Smith L, Erwin-Cohen R, Tammariello R, Hale M, DaSilva L.

Toxicon. 2011 Jul;58(1):68-75. doi: 10.1016/j.toxicon.2011.05.005. Epub 2011 May 17.

PMID:
21616091
2.

Progress in biological threat agent vaccine development: a repeat-dose toxicity study of a recombinant ricin toxin A-chain (rRTA) 1-33/44-198 vaccine (RVEc) in male and female New Zealand white rabbits.

McLain DE, Horn TL, Detrisac CJ, Lindsey CY, Smith LA.

Int J Toxicol. 2011 Mar;30(2):143-52. doi: 10.1177/1091581810396730. Epub 2011 Mar 4.

PMID:
21378370
3.

Comparative efficacy of two leading candidate ricin toxin a subunit vaccines in mice.

O'Hara JM, Brey RN 3rd, Mantis NJ.

Clin Vaccine Immunol. 2013 Jun;20(6):789-94. doi: 10.1128/CVI.00098-13. Epub 2013 Mar 20.

4.

Strong protection against ricin challenge induced by a novel modified ricin A-chain protein in mouse model.

Zhang T, Yang H, Kang L, Gao S, Xin W, Yao W, Zhuang X, Ji B, Wang J.

Hum Vaccin Immunother. 2015;11(7):1779-87. doi: 10.1080/21645515.2015.1038446.

5.
7.

Introduction of a disulfide bond into ricin A chain decreases the cytotoxicity of the ricin holotoxin.

Argent RH, Roberts LM, Wales R, Robertus JD, Lord JM.

J Biol Chem. 1994 Oct 28;269(43):26705-10.

8.

Assessment of ligand effects in intracellular trafficking of ricin A chain using anti-ricin hybridomas.

Kornfeld SB, Leonard JE, Mullen MD, Taetle R.

Cancer Res. 1991 Mar 15;51(6):1689-93.

9.

Finding a new vaccine in the ricin protein fold.

Olson MA, Carra JH, Roxas-Duncan V, Wannemacher RW, Smith LA, Millard CB.

Protein Eng Des Sel. 2004 Apr;17(4):391-7. Epub 2004 Jun 8.

PMID:
15187223
10.

A novel recombinant vaccine which protects mice against ricin intoxication.

Smallshaw JE, Firan A, Fulmer JR, Ruback SL, Ghetie V, Vitetta ES.

Vaccine. 2002 Sep 10;20(27-28):3422-7.

PMID:
12213413
11.

Lectin-deficient ricin toxin intoxicates cells bearing the D-mannose receptor.

Frankel AE, Fu T, Burbage C, Tagge E, Harris B, Vesely J, Willingham MC.

Carbohydr Res. 1997 May 16;300(3):251-8.

PMID:
9202409
12.

Thermostable ricin vaccine protects rhesus macaques against aerosolized ricin: Epitope-specific neutralizing antibodies correlate with protection.

Roy CJ, Brey RN, Mantis NJ, Mapes K, Pop IV, Pop LM, Ruback S, Killeen SZ, Doyle-Meyers L, Vinet-Oliphant HS, Didier PJ, Vitetta ES.

Proc Natl Acad Sci U S A. 2015 Mar 24;112(12):3782-7. doi: 10.1073/pnas.1502585112. Epub 2015 Mar 9.

13.

Degradation of ricin A chain by endosomal and lysosomal enzymes--the protective role of ricin B chain.

Bilge A, Howell-Clark J, Ramakrishnan S, Press OW.

Ther Immunol. 1994 Aug;1(4):197-204.

PMID:
7584495
14.

A monoclonal immunoglobulin G antibody directed against an immunodominant linear epitope on the ricin A chain confers systemic and mucosal immunity to ricin.

Neal LM, O'Hara J, Brey RN 3rd, Mantis NJ.

Infect Immun. 2010 Jan;78(1):552-61. doi: 10.1128/IAI.00796-09. Epub 2009 Oct 26.

15.

Differences in cytotoxicity of native and engineered RIPs can be used to assess their ability to reach the cytoplasm.

Svinth M, Steighardt J, Hernandez R, Suh JK, Kelly C, Day P, Lord M, Girbes T, Robertus JD.

Biochem Biophys Res Commun. 1998 Aug 28;249(3):637-42.

PMID:
9731188
16.

Co-application of ricin A chain and a recombinant adenovirus expressing ricin B chain as a novel approach for cancer therapy.

Wang HB, Xia F, Ge J, Yin J, Tan LS, Zhang PD, Zhong J.

Acta Pharmacol Sin. 2007 May;28(5):657-62.

17.

EL4 cell-based colorimetric toxin neutralization activity assays for determination of neutralizing anti-ricin antibodies.

Lindsey CY, Brown JE, Torabazar NR, Smith LA.

J AOAC Int. 2013 Jan-Feb;96(1):147-54.

PMID:
23513970
18.

IL2 fused to lectin-deficient ricin is toxic to human leukemia cells expressing the IL2 receptor.

Frankel AE, Fu T, Burbage C, Chandler J, Willingham MC, Tagge EP.

Leukemia. 1997 Jan;11(1):22-30.

PMID:
9001414
19.

Ricin toxin contains at least three galactose-binding sites located in B chain subdomains 1 alpha, 1 beta, and 2 gamma.

Frankel AE, Burbage C, Fu T, Tagge E, Chandler J, Willingham MC.

Biochemistry. 1996 Nov 26;35(47):14749-56.

PMID:
8942636
20.

Ricin. Mechanisms of cytotoxicity.

Lord MJ, Jolliffe NA, Marsden CJ, Pateman CS, Smith DC, Spooner RA, Watson PD, Roberts LM.

Toxicol Rev. 2003;22(1):53-64. Review.

PMID:
14579547

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