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Items: 1 to 20 of 92


Identification of cryptic products of the gliotoxin gene cluster using NMR-based comparative metabolomics and a model for gliotoxin biosynthesis.

Forseth RR, Fox EM, Chung D, Howlett BJ, Keller NP, Schroeder FC.

J Am Chem Soc. 2011 Jun 29;133(25):9678-81. doi: 10.1021/ja2029987. Epub 2011 Jun 6.


GliZ, a transcriptional regulator of gliotoxin biosynthesis, contributes to Aspergillus fumigatus virulence.

Bok JW, Chung D, Balajee SA, Marr KA, Andes D, Nielsen KF, Frisvad JC, Kirby KA, Keller NP.

Infect Immun. 2006 Dec;74(12):6761-8. Epub 2006 Oct 9.


Resistance is not futile: gliotoxin biosynthesis, functionality and utility.

Dolan SK, O'Keeffe G, Jones GW, Doyle S.

Trends Microbiol. 2015 Jul;23(7):419-28. doi: 10.1016/j.tim.2015.02.005. Epub 2015 Mar 10. Review.


Deletion of the gliP gene of Aspergillus fumigatus results in loss of gliotoxin production but has no effect on virulence of the fungus in a low-dose mouse infection model.

Kupfahl C, Heinekamp T, Geginat G, Ruppert T, Härtl A, Hof H, Brakhage AA.

Mol Microbiol. 2006 Oct;62(1):292-302. Epub 2006 Aug 31.


What do we know about the role of gliotoxin in the pathobiology of Aspergillus fumigatus?

Kwon-Chung KJ, Sugui JA.

Med Mycol. 2009;47 Suppl 1:S97-103. doi: 10.1080/13693780802056012. Epub 2008 May 2. Review.


The role of glutathione S-transferase GliG in gliotoxin biosynthesis in Aspergillus fumigatus.

Davis C, Carberry S, Schrettl M, Singh I, Stephens JC, Barry SM, Kavanagh K, Challis GL, Brougham D, Doyle S.

Chem Biol. 2011 Apr 22;18(4):542-52. doi: 10.1016/j.chembiol.2010.12.022.


VeA regulates conidiation, gliotoxin production, and protease activity in the opportunistic human pathogen Aspergillus fumigatus.

Dhingra S, Andes D, Calvo AM.

Eukaryot Cell. 2012 Dec;11(12):1531-43. doi: 10.1128/EC.00222-12. Epub 2012 Oct 19.


Disruption of a nonribosomal peptide synthetase in Aspergillus fumigatus eliminates gliotoxin production.

Cramer RA Jr, Gamcsik MP, Brooking RM, Najvar LK, Kirkpatrick WR, Patterson TF, Balibar CJ, Graybill JR, Perfect JR, Abraham SN, Steinbach WJ.

Eukaryot Cell. 2006 Jun;5(6):972-80.


The Aspergillus fumigatus protein GliK protects against oxidative stress and is essential for gliotoxin biosynthesis.

Gallagher L, Owens RA, Dolan SK, O'Keeffe G, Schrettl M, Kavanagh K, Jones GW, Doyle S.

Eukaryot Cell. 2012 Oct;11(10):1226-38. doi: 10.1128/EC.00113-12. Epub 2012 Aug 17.


Interplay between Gliotoxin Resistance, Secretion, and the Methyl/Methionine Cycle in Aspergillus fumigatus.

Owens RA, O'Keeffe G, Smith EB, Dolan SK, Hammel S, Sheridan KJ, Fitzpatrick DA, Keane TM, Jones GW, Doyle S.

Eukaryot Cell. 2015 Sep;14(9):941-57. doi: 10.1128/EC.00055-15. Epub 2015 Jul 6.


Structural, mechanistic and functional insight into gliotoxin bis-thiomethylation in Aspergillus fumigatus.

Dolan SK, Bock T, Hering V, Owens RA, Jones GW, Blankenfeldt W, Doyle S.

Open Biol. 2017 Feb;7(2). pii: 160292. doi: 10.1098/rsob.160292.


RNA-seq reveals the pan-transcriptomic impact of attenuating the gliotoxin self-protection mechanism in Aspergillus fumigatus.

O'Keeffe G, Hammel S, Owens RA, Keane TM, Fitzpatrick DA, Jones GW, Doyle S.

BMC Genomics. 2014 Oct 14;15:894. doi: 10.1186/1471-2164-15-894.


Self-protection against gliotoxin--a component of the gliotoxin biosynthetic cluster, GliT, completely protects Aspergillus fumigatus against exogenous gliotoxin.

Schrettl M, Carberry S, Kavanagh K, Haas H, Jones GW, O'Brien J, Nolan A, Stephens J, Fenelon O, Doyle S.

PLoS Pathog. 2010 Jun 10;6(6):e1000952. doi: 10.1371/journal.ppat.1000952.


Gliotoxin is a virulence factor of Aspergillus fumigatus: gliP deletion attenuates virulence in mice immunosuppressed with hydrocortisone.

Sugui JA, Pardo J, Chang YC, Zarember KA, Nardone G, Galvez EM, Müllbacher A, Gallin JI, Simon MM, Kwon-Chung KJ.

Eukaryot Cell. 2007 Sep;6(9):1562-9. Epub 2007 Jun 29.


GliA in Aspergillus fumigatus is required for its tolerance to gliotoxin and affects the amount of extracellular and intracellular gliotoxin.

Wang DN, Toyotome T, Muraosa Y, Watanabe A, Wuren T, Bunsupa S, Aoyagi K, Yamazaki M, Takino M, Kamei K.

Med Mycol. 2014 Jul;52(5):506-18. doi: 10.1093/mmy/myu007. Epub 2014 May 20.


RsmA regulates Aspergillus fumigatus gliotoxin cluster metabolites including cyclo(L-Phe-L-Ser), a potential new diagnostic marker for invasive aspergillosis.

Sekonyela R, Palmer JM, Bok JW, Jain S, Berthier E, Forseth R, Schroeder F, Keller NP.

PLoS One. 2013 May 6;8(5):e62591. doi: 10.1371/journal.pone.0062591. Print 2013.


Gliotoxin production in Aspergillus fumigatus contributes to host-specific differences in virulence.

Spikes S, Xu R, Nguyen CK, Chamilos G, Kontoyiannis DP, Jacobson RH, Ejzykowicz DE, Chiang LY, Filler SG, May GS.

J Infect Dis. 2008 Feb 1;197(3):479-86. doi: 10.1086/525044.


Opposed effects of enzymatic gliotoxin N- and S-methylations.

Scharf DH, Habel A, Heinekamp T, Brakhage AA, Hertweck C.

J Am Chem Soc. 2014 Aug 20;136(33):11674-9. doi: 10.1021/ja5033106. Epub 2014 Aug 7.


Biosynthesis and function of gliotoxin in Aspergillus fumigatus.

Scharf DH, Heinekamp T, Remme N, Hortschansky P, Brakhage AA, Hertweck C.

Appl Microbiol Biotechnol. 2012 Jan;93(2):467-72. doi: 10.1007/s00253-011-3689-1. Epub 2011 Nov 18. Review.


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