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Items: 1 to 20 of 172

1.

Transcription factors KLF1 and KLF2 positively regulate embryonic and fetal beta-globin genes through direct promoter binding.

Alhashem YN, Vinjamur DS, Basu M, Klingmüller U, Gaensler KM, Lloyd JA.

J Biol Chem. 2011 Jul 15;286(28):24819-27. doi: 10.1074/jbc.M111.247536. Epub 2011 May 24.

2.

Kruppel-like factor 1 (KLF1), KLF2, and Myc control a regulatory network essential for embryonic erythropoiesis.

Pang CJ, Lemsaddek W, Alhashem YN, Bondzi C, Redmond LC, Ah-Son N, Dumur CI, Archer KJ, Haar JL, Lloyd JA, Trudel M.

Mol Cell Biol. 2012 Jul;32(13):2628-44. doi: 10.1128/MCB.00104-12. Epub 2012 May 7.

3.

KLF2 is essential for primitive erythropoiesis and regulates the human and murine embryonic beta-like globin genes in vivo.

Basu P, Morris PE, Haar JL, Wani MA, Lingrel JB, Gaensler KM, Lloyd JA.

Blood. 2005 Oct 1;106(7):2566-71. Epub 2005 Jun 9.

4.

EKLF and KLF2 have compensatory roles in embryonic beta-globin gene expression and primitive erythropoiesis.

Basu P, Lung TK, Lemsaddek W, Sargent TG, Williams DC Jr, Basu M, Redmond LC, Lingrel JB, Haar JL, Lloyd JA.

Blood. 2007 Nov 1;110(9):3417-25. Epub 2007 Aug 3.

5.

Krüppel-like transcription factors KLF1 and KLF2 have unique and coordinate roles in regulating embryonic erythroid precursor maturation.

Vinjamur DS, Wade KJ, Mohamad SF, Haar JL, Sawyer ST, Lloyd JA.

Haematologica. 2014 Oct;99(10):1565-73. doi: 10.3324/haematol.2014.104943. Epub 2014 Aug 22.

6.

Erythropoiesis and globin switching in compound Klf1::Bcl11a mutant mice.

Esteghamat F, Gillemans N, Bilic I, van den Akker E, Cantù I, van Gent T, Klingmüller U, van Lom K, von Lindern M, Grosveld F, Bryn van Dijk T, Busslinger M, Philipsen S.

Blood. 2013 Mar 28;121(13):2553-62. doi: 10.1182/blood-2012-06-434530. Epub 2013 Jan 29.

7.

Krüppel-Like Transcription Factor KLF1 Is Required for Optimal γ- and β-Globin Expression in Human Fetal Erythroblasts.

Vinjamur DS, Alhashem YN, Mohamad SF, Amin P, Williams DC Jr, Lloyd JA.

PLoS One. 2016 Feb 3;11(2):e0146802. doi: 10.1371/journal.pone.0146802. eCollection 2016.

8.

Krüppel-like factor 2 regulated gene expression in mouse embryonic yolk sac erythroid cells.

Redmond LC, Dumur CI, Archer KJ, Grayson DR, Haar JL, Lloyd JA.

Blood Cells Mol Dis. 2011 Jun 15;47(1):1-11. doi: 10.1016/j.bcmd.2011.03.002. Epub 2011 Apr 29.

9.

Three fingers on the switch: Krüppel-like factor 1 regulation of γ-globin to β-globin gene switching.

Tallack MR, Perkins AC.

Curr Opin Hematol. 2013 May;20(3):193-200. doi: 10.1097/MOH.0b013e32835f59ba. Review.

PMID:
23474875
10.

Differential regulation of the α-globin locus by Krüppel-like Factor 3 in erythroid and non-erythroid cells.

Funnell AP, Vernimmen D, Lim WF, Mak KS, Wienert B, Martyn GE, Artuz CM, Burdach J, Quinlan KG, Higgs DR, Whitelaw E, Pearson RC, Crossley M.

BMC Mol Biol. 2014 May 16;15:8. doi: 10.1186/1471-2199-15-8.

11.

KLF1 regulates BCL11A expression and gamma- to beta-globin gene switching.

Zhou D, Liu K, Sun CW, Pawlik KM, Townes TM.

Nat Genet. 2010 Sep;42(9):742-4. doi: 10.1038/ng.637. Epub 2010 Aug 1.

PMID:
20676097
12.

KLF1 stabilizes GATA-1 and TAL1 occupancy in the human β-globin locus.

Kang Y, Kim YW, Yun J, Shin J, Kim A.

Biochim Biophys Acta. 2015 Mar;1849(3):282-9. doi: 10.1016/j.bbagrm.2014.12.010. Epub 2014 Dec 17.

PMID:
25528728
13.

A functional screen for Krüppel-like factors that regulate the human gamma-globin gene through the CACCC promoter element.

Zhang P, Basu P, Redmond LC, Morris PE, Rupon JW, Ginder GD, Lloyd JA.

Blood Cells Mol Dis. 2005 Sep-Oct;35(2):227-35.

PMID:
16023392
14.

A transient definitive erythroid lineage with unique regulation of the β-globin locus in the mammalian embryo.

McGrath KE, Frame JM, Fromm GJ, Koniski AD, Kingsley PD, Little J, Bulger M, Palis J.

Blood. 2011 Apr 28;117(17):4600-8. doi: 10.1182/blood-2010-12-325357. Epub 2011 Mar 4.

15.

Transcription factor EKLF (KLF1) recruitment of the histone chaperone HIRA is essential for β-globin gene expression.

Soni S, Pchelintsev N, Adams PD, Bieker JJ.

Proc Natl Acad Sci U S A. 2014 Sep 16;111(37):13337-42. doi: 10.1073/pnas.1405422111. Epub 2014 Sep 2.

16.

The role of EKLF in human beta-globin gene competition.

Wijgerde M, Gribnau J, Trimborn T, Nuez B, Philipsen S, Grosveld F, Fraser P.

Genes Dev. 1996 Nov 15;10(22):2894-902.

17.

Krüppel-like Factor 4 activates HBG gene expression in primary erythroid cells.

Kalra IS, Alam MM, Choudhary PK, Pace BS.

Br J Haematol. 2011 Jul;154(2):248-59. doi: 10.1111/j.1365-2141.2011.08710.x. Epub 2011 May 3.

18.

The Krüppel-like factor 2 and Krüppel-like factor 4 genes interact to maintain endothelial integrity in mouse embryonic vasculogenesis.

Chiplunkar AR, Curtis BC, Eades GL, Kane MS, Fox SJ, Haar JL, Lloyd JA.

BMC Dev Biol. 2013 Nov 22;13:40. doi: 10.1186/1471-213X-13-40.

19.

Induction of adult levels of β-globin in human erythroid cells that intrinsically express embryonic or fetal globin by transduction with KLF1 and BCL11A-XL.

Trakarnsanga K, Wilson MC, Lau W, Singleton BK, Parsons SF, Sakuntanaga P, Kurita R, Nakamura Y, Anstee DJ, Frayne J.

Haematologica. 2014 Nov;99(11):1677-85. doi: 10.3324/haematol.2014.110155. Epub 2014 Aug 8.

20.

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