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Items: 1 to 20 of 99

1.

Determining allosteric modulator mechanism of action: integration of radioligand binding and functional assay data.

Langmead CJ.

Methods Mol Biol. 2011;746:195-209. doi: 10.1007/978-1-61779-126-0_10.

PMID:
21607858
2.

A novel mechanism of G protein-coupled receptor functional selectivity. Muscarinic partial agonist McN-A-343 as a bitopic orthosteric/allosteric ligand.

Valant C, Gregory KJ, Hall NE, Scammells PJ, Lew MJ, Sexton PM, Christopoulos A.

J Biol Chem. 2008 Oct 24;283(43):29312-21. doi: 10.1074/jbc.M803801200. Epub 2008 Aug 22.

3.

Allosteric interactions at muscarinic cholinoceptors.

Christopoulos A, Lanzafame A, Mitchelson F.

Clin Exp Pharmacol Physiol. 1998 Mar-Apr;25(3-4):185-94. Review.

PMID:
9590567
4.

Interactions of orthosteric and allosteric ligands with [3H]dimethyl-W84 at the common allosteric site of muscarinic M2 receptors.

Tränkle C, Weyand O, Voigtländer U, Mynett A, Lazareno S, Birdsall NJ, Mohr K.

Mol Pharmacol. 2003 Jul;64(1):180-90.

5.

The impact of orthosteric radioligand depletion on the quantification of allosteric modulator interactions.

Avlani VA, McLoughlin DJ, Sexton PM, Christopoulos A.

J Pharmacol Exp Ther. 2008 Jun;325(3):927-34. doi: 10.1124/jpet.108.136978. Epub 2008 Mar 5.

6.

Allosteric modulators of G-protein-coupled receptors.

May LT, Christopoulos A.

Curr Opin Pharmacol. 2003 Oct;3(5):551-6. Review.

PMID:
14559102
7.

Allosteric modulation of G protein-coupled receptors.

May LT, Avlani VA, Sexton PM, Christopoulos A.

Curr Pharm Des. 2004;10(17):2003-13. Review.

PMID:
15279541
8.

Discovery and characterization of orthosteric and allosteric muscarinic M2 acetylcholine receptor ligands by affinity selection-mass spectrometry.

Whitehurst CE, Nazef N, Annis DA, Hou Y, Murphy DM, Spacciapoli P, Yao Z, Ziebell MR, Cheng CC, Shipps GW Jr, Felsch JS, Lau D, Nash HM.

J Biomol Screen. 2006 Mar;11(2):194-207. Epub 2006 Feb 20.

PMID:
16490772
10.

Towards a high-affinity allosteric enhancer at muscarinic M1 receptors.

Lazareno S, Popham A, Birdsall NJ.

J Mol Neurosci. 2002 Aug-Oct;19(1-2):123-7.

PMID:
12212769
11.

Allosteric properties of G protein-coupled receptor oligomers.

Springael JY, Urizar E, Costagliola S, Vassart G, Parmentier M.

Pharmacol Ther. 2007 Sep;115(3):410-8. Epub 2007 Jun 27. Review.

PMID:
17655934
12.

G protein-coupled receptor allosterism and complexing.

Christopoulos A, Kenakin T.

Pharmacol Rev. 2002 Jun;54(2):323-74. Review.

13.

Application of a kinetic model to the apparently complex behavior of negative and positive allosteric modulators of muscarinic acetylcholine receptors.

Avlani V, May LT, Sexton PM, Christopoulos A.

J Pharmacol Exp Ther. 2004 Mar;308(3):1062-72. Epub 2004 Jan 7.

14.

Identification of a [3H]Ligand for the common allosteric site of muscarinic acetylcholine M2 receptors.

Tränkle C, Mies-Klomfass E, Cid MH, Holzgrabe U, Mohr K.

Mol Pharmacol. 1998 Jul;54(1):139-45.

15.
16.

The role of transmembrane domain 3 in the actions of orthosteric, allosteric, and atypical agonists of the M4 muscarinic acetylcholine receptor.

Leach K, Davey AE, Felder CC, Sexton PM, Christopoulos A.

Mol Pharmacol. 2011 May;79(5):855-65. doi: 10.1124/mol.111.070938. Epub 2011 Feb 7.

18.

Critical role for the second extracellular loop in the binding of both orthosteric and allosteric G protein-coupled receptor ligands.

Avlani VA, Gregory KJ, Morton CJ, Parker MW, Sexton PM, Christopoulos A.

J Biol Chem. 2007 Aug 31;282(35):25677-86. Epub 2007 Jun 25.

19.

Orthosteric and allosteric modes of interaction of novel selective agonists of the M1 muscarinic acetylcholine receptor.

Avlani VA, Langmead CJ, Guida E, Wood MD, Tehan BG, Herdon HJ, Watson JM, Sexton PM, Christopoulos A.

Mol Pharmacol. 2010 Jul;78(1):94-104. doi: 10.1124/mol.110.064345. Epub 2010 Apr 22.

20.

Allosteric modulation of family C G-protein-coupled receptors: from molecular insights to therapeutic perspectives.

Urwyler S.

Pharmacol Rev. 2011 Mar;63(1):59-126. doi: 10.1124/pr.109.002501. Epub 2011 Jan 12. Review.

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