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A herpesvirus kinase that masquerades as Akt: you don't have to look like Akt, to act like it.

Chuluunbaatar U, Mohr I.

Cell Cycle. 2011 Jul 1;10(13):2064-8. Epub 2011 Jul 1.


Constitutive mTORC1 activation by a herpesvirus Akt surrogate stimulates mRNA translation and viral replication.

Chuluunbaatar U, Roller R, Feldman ME, Brown S, Shokat KM, Mohr I.

Genes Dev. 2010 Dec 1;24(23):2627-39. doi: 10.1101/gad.1978310.


Subversion of Host Responses to Energy Insufficiency by Us3 Supports Herpes Simplex Virus 1 Replication during Stress.

Vink EI, Smiley JR, Mohr I.

J Virol. 2017 Jun 26;91(14). pii: e00295-17. doi: 10.1128/JVI.00295-17. Print 2017 Jul 15.


Herpes Simplex Virus is Akt-ing in translational control.

Norman KL, Sarnow P.

Genes Dev. 2010 Dec 1;24(23):2583-6. doi: 10.1101/gad.2004510.


Growth-factor dependent expression of the translationally controlled tumour protein TCTP is regulated through the PI3-K/Akt/mTORC1 signalling pathway.

Bommer UA, Iadevaia V, Chen J, Knoch B, Engel M, Proud CG.

Cell Signal. 2015 Aug;27(8):1557-68. doi: 10.1016/j.cellsig.2015.04.011. Epub 2015 Apr 30.


RhoA modulates signaling through the mechanistic target of rapamycin complex 1 (mTORC1) in mammalian cells.

Gordon BS, Kazi AA, Coleman CS, Dennis MD, Chau V, Jefferson LS, Kimball SR.

Cell Signal. 2014 Mar;26(3):461-7. doi: 10.1016/j.cellsig.2013.11.035. Epub 2013 Dec 3.


4E-BP1, a repressor of mRNA translation, is phosphorylated and inactivated by the Akt(PKB) signaling pathway.

Gingras AC, Kennedy SG, O'Leary MA, Sonenberg N, Hay N.

Genes Dev. 1998 Feb 15;12(4):502-13.


ERK and AKT signaling cooperate to translationally regulate survivin expression for metastatic progression of colorectal cancer.

Ye Q, Cai W, Zheng Y, Evers BM, She QB.

Oncogene. 2014 Apr 3;33(14):1828-39. doi: 10.1038/onc.2013.122. Epub 2013 Apr 29.


p53/TAp63 and AKT regulate mammalian target of rapamycin complex 1 (mTORC1) signaling through two independent parallel pathways in the presence of DNA damage.

Cam M, Bid HK, Xiao L, Zambetti GP, Houghton PJ, Cam H.

J Biol Chem. 2014 Feb 14;289(7):4083-94. doi: 10.1074/jbc.M113.530303. Epub 2013 Dec 23.


Rapamycin attenuates BAFF-extended proliferation and survival via disruption of mTORC1/2 signaling in normal and neoplastic B-lymphoid cells.

Zeng Q, Qin S, Zhang H, Liu B, Qin J, Wang X, Zhang R, Liu C, Dong X, Zhang S, Huang S, Chen L.

J Cell Physiol. 2018 Jan;233(1):516-529. doi: 10.1002/jcp.25913. Epub 2017 May 3.


Phosphatase control of 4E-BP1 phosphorylation state is central for glycolytic regulation of retinal protein synthesis.

Gardner TW, Abcouwer SF, Losiewicz MK, Fort PE.

Am J Physiol Endocrinol Metab. 2015 Sep 15;309(6):E546-56. doi: 10.1152/ajpendo.00180.2015. Epub 2015 Jul 21.


Herpes simplex virus protein kinases US3 and UL13 modulate VP11/12 phosphorylation, virion packaging, and phosphatidylinositol 3-kinase/Akt signaling activity.

Eaton HE, Saffran HA, Wu FW, Quach K, Smiley JR.

J Virol. 2014 Jul;88(13):7379-88. doi: 10.1128/JVI.00712-14. Epub 2014 Apr 16.


Akt-dependent activation of mTORC1 complex involves phosphorylation of mTOR (mammalian target of rapamycin) by IκB kinase α (IKKα).

Dan HC, Ebbs A, Pasparakis M, Van Dyke T, Basseres DS, Baldwin AS.

J Biol Chem. 2014 Sep 5;289(36):25227-40. doi: 10.1074/jbc.M114.554881. Epub 2014 Jul 2.


Constitutive phosphorylation of the mTORC2/Akt/4E-BP1 pathway in newly derived canine hemangiosarcoma cell lines.

Murai A, Asa SA, Kodama A, Hirata A, Yanai T, Sakai H.

BMC Vet Res. 2012 Jul 29;8:128. doi: 10.1186/1746-6148-8-128.


Both mTORC1 and mTORC2 are involved in the regulation of cell adhesion.

Chen L, Xu B, Liu L, Liu C, Luo Y, Chen X, Barzegar M, Chung J, Huang S.

Oncotarget. 2015 Mar 30;6(9):7136-50.


Cellular entry of human papillomavirus type 16 involves activation of the phosphatidylinositol 3-kinase/Akt/mTOR pathway and inhibition of autophagy.

Surviladze Z, Sterk RT, DeHaro SA, Ozbun MA.

J Virol. 2013 Mar;87(5):2508-17. doi: 10.1128/JVI.02319-12. Epub 2012 Dec 19.


Feedback loops blockade potentiates apoptosis induction and antitumor activity of a novel AKT inhibitor DC120 in human liver cancer.

Yang F, Deng R, Qian XJ, Chang SH, Wu XQ, Qin J, Feng GK, Ding K, Zhu XF.

Cell Death Dis. 2014 Mar 13;5:e1114. doi: 10.1038/cddis.2014.43.


Phosphatidylinositol-3 kinase-dependent translational regulation of Id1 involves the PPM1G phosphatase.

Xu K, Wang L, Feng W, Feng Y, Shu HK.

Oncogene. 2016 Nov 3;35(44):5807-5816. doi: 10.1038/onc.2016.115. Epub 2016 Apr 11.

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