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Items: 1 to 20 of 254

1.

Role of mTOR in podocyte function and diabetic nephropathy in humans and mice.

Gödel M, Hartleben B, Herbach N, Liu S, Zschiedrich S, Lu S, Debreczeni-Mór A, Lindenmeyer MT, Rastaldi MP, Hartleben G, Wiech T, Fornoni A, Nelson RG, Kretzler M, Wanke R, Pavenstädt H, Kerjaschki D, Cohen CD, Hall MN, Rüegg MA, Inoki K, Walz G, Huber TB.

J Clin Invest. 2011 Jun;121(6):2197-209. doi: 10.1172/JCI44774. Epub 2011 May 23.

2.

The targeted podocyte.

Fogo AB.

J Clin Invest. 2011 Jun;121(6):2142-5. doi: 10.1172/JCI57935. Epub 2011 May 23.

3.

mTORC1 activation in podocytes is a critical step in the development of diabetic nephropathy in mice.

Inoki K, Mori H, Wang J, Suzuki T, Hong S, Yoshida S, Blattner SM, Ikenoue T, Rüegg MA, Hall MN, Kwiatkowski DJ, Rastaldi MP, Huber TB, Kretzler M, Holzman LB, Wiggins RC, Guan KL.

J Clin Invest. 2011 Jun;121(6):2181-96. doi: 10.1172/JCI44771. Epub 2011 May 23.

4.

Translationally controlled tumour protein is associated with podocyte hypertrophy in a mouse model of type 1 diabetes.

Kim DK, Nam BY, Li JJ, Park JT, Lee SH, Kim DH, Kim JY, Kang HY, Han SH, Yoo TH, Han DS, Kang SW.

Diabetologia. 2012 Apr;55(4):1205-17. doi: 10.1007/s00125-012-2467-7. Epub 2012 Feb 4.

PMID:
22311416
5.

Role of Ragulator in the Regulation of Mechanistic Target of Rapamycin Signaling in Podocytes and Glomerular Function.

Yao Y, Wang J, Yoshida S, Nada S, Okada M, Inoki K.

J Am Soc Nephrol. 2016 Dec;27(12):3653-3665. Epub 2016 Mar 31.

6.

Mangiferin prevents diabetic nephropathy progression and protects podocyte function via autophagy in diabetic rat glomeruli.

Wang X, Gao L, Lin H, Song J, Wang J, Yin Y, Zhao J, Xu X, Li Z, Li L.

Eur J Pharmacol. 2018 Apr 5;824:170-178. doi: 10.1016/j.ejphar.2018.02.009. Epub 2018 Feb 11.

PMID:
29444469
7.

Glomerular barrier dysfunction in glomerulosclerosis- resistant Milan rats with experimental diabetes: the role of renal haemodynamics.

Pugliese G, Ricci C, Iacobini C, Menini S, Fioretto P, Ferrandi M, Giardino LA, Armelloni S, Mattinzoli D, Rastaldi MP, Pugliese F.

J Pathol. 2007 Oct;213(2):210-8. Erratum in: J Pathol. 2007 Oct;213(2):218.

PMID:
17768702
8.

Podocytes produce homeostatic chemokine stromal cell-derived factor-1/CXCL12, which contributes to glomerulosclerosis, podocyte loss and albuminuria in a mouse model of type 2 diabetes.

Sayyed SG, Hägele H, Kulkarni OP, Endlich K, Segerer S, Eulberg D, Klussmann S, Anders HJ.

Diabetologia. 2009 Nov;52(11):2445-54. doi: 10.1007/s00125-009-1493-6. Epub 2009 Aug 26.

PMID:
19707743
9.

Loss of the podocyte-expressed transcription factor Tcf21/Pod1 results in podocyte differentiation defects and FSGS.

Maezawa Y, Onay T, Scott RP, Keir LS, Dimke H, Li C, Eremina V, Maezawa Y, Jeansson M, Shan J, Binnie M, Lewin M, Ghosh A, Miner JH, Vainio SJ, Quaggin SE.

J Am Soc Nephrol. 2014 Nov;25(11):2459-70. doi: 10.1681/ASN.2013121307. Epub 2014 Jun 5.

10.

Impaired Podocyte Autophagy Exacerbates Proteinuria in Diabetic Nephropathy.

Tagawa A, Yasuda M, Kume S, Yamahara K, Nakazawa J, Chin-Kanasaki M, Araki H, Araki S, Koya D, Asanuma K, Kim EH, Haneda M, Kajiwara N, Hayashi K, Ohashi H, Ugi S, Maegawa H, Uzu T.

Diabetes. 2016 Mar;65(3):755-67. doi: 10.2337/db15-0473. Epub 2015 Sep 17.

11.

Endothelial cell and podocyte autophagy synergistically protect from diabetes-induced glomerulosclerosis.

Lenoir O, Jasiek M, Hénique C, Guyonnet L, Hartleben B, Bork T, Chipont A, Flosseau K, Bensaada I, Schmitt A, Massé JM, Souyri M, Huber TB, Tharaux PL.

Autophagy. 2015;11(7):1130-45. doi: 10.1080/15548627.2015.1049799.

12.

Pathogenesis of the podocytopathy and proteinuria in diabetic glomerulopathy.

Ziyadeh FN, Wolf G.

Curr Diabetes Rev. 2008 Feb;4(1):39-45. Review.

PMID:
18220694
13.

The role of mechanistic target of rapamycin in maintenance of glomerular epithelial cells.

Yao Y, Inoki K.

Curr Opin Nephrol Hypertens. 2016 Jan;25(1):28-34. doi: 10.1097/MNH.0000000000000181. Review.

14.

Podocyte-specific Nox4 deletion affords renoprotection in a mouse model of diabetic nephropathy.

Jha JC, Thallas-Bonke V, Banal C, Gray SP, Chow BS, Ramm G, Quaggin SE, Cooper ME, Schmidt HH, Jandeleit-Dahm KA.

Diabetologia. 2016 Feb;59(2):379-89. doi: 10.1007/s00125-015-3796-0. Epub 2015 Oct 28.

15.

Increased glomerular cell (podocyte) apoptosis in rats with streptozotocin-induced diabetes mellitus: role in the development of diabetic glomerular disease.

Menini S, Iacobini C, Oddi G, Ricci C, Simonelli P, Fallucca S, Grattarola M, Pugliese F, Pesce C, Pugliese G.

Diabetologia. 2007 Dec;50(12):2591-9. Epub 2007 Sep 28.

PMID:
17901943
16.

Targeting mTOR Signaling Can Prevent the Progression of FSGS.

Zschiedrich S, Bork T, Liang W, Wanner N, Eulenbruch K, Munder S, Hartleben B, Kretz O, Gerber S, Simons M, Viau A, Burtin M, Wei C, Reiser J, Herbach N, Rastaldi MP, Cohen CD, Tharaux PL, Terzi F, Walz G, Gödel M, Huber TB.

J Am Soc Nephrol. 2017 Jul;28(7):2144-2157. doi: 10.1681/ASN.2016050519. Epub 2017 Mar 7.

17.

Fatty acids are novel nutrient factors to regulate mTORC1 lysosomal localization and apoptosis in podocytes.

Yasuda M, Tanaka Y, Kume S, Morita Y, Chin-Kanasaki M, Araki H, Isshiki K, Araki S, Koya D, Haneda M, Kashiwagi A, Maegawa H, Uzu T.

Biochim Biophys Acta. 2014 Jul;1842(7):1097-108. doi: 10.1016/j.bbadis.2014.04.001. Epub 2014 Apr 13.

18.

mTOR in podocyte function: is rapamycin good for diabetic nephropathy?

Lu MK, Gong XG, Guan KL.

Cell Cycle. 2011 Oct 15;10(20):3415-6. doi: 10.4161/cc.10.20.17686. No abstract available.

19.

Lack of {alpha}8-integrin aggravates podocyte injury in experimental diabetic nephropathy.

Hartner A, Cordasic N, Menendez-Castro C, Volkert G, Yabu JM, Kupraszewicz-Hutzler M, Rascher W, Hilgers KF.

Am J Physiol Renal Physiol. 2010 Nov;299(5):F1151-7. doi: 10.1152/ajprenal.00058.2010. Epub 2010 Sep 8.

20.

mTORC2 Signaling Regulates Nox4-Induced Podocyte Depletion in Diabetes.

Eid S, Boutary S, Braych K, Sabra R, Massaad C, Hamdy A, Rashid A, Moodad S, Block K, Gorin Y, Abboud HE, Eid AA.

Antioxid Redox Signal. 2016 Nov 1;25(13):703-719. Epub 2016 Sep 12.

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