Sort by
Items per page

Send to

Choose Destination

Links from PubMed

Items: 1 to 20 of 186


Endothelium-protective sphingosine-1-phosphate provided by HDL-associated apolipoprotein M.

Christoffersen C, Obinata H, Kumaraswamy SB, Galvani S, Ahnström J, Sevvana M, Egerer-Sieber C, Muller YA, Hla T, Nielsen LB, Dahlbäck B.

Proc Natl Acad Sci U S A. 2011 Jun 7;108(23):9613-8. doi: 10.1073/pnas.1103187108. Epub 2011 May 23.


Hepatic apolipoprotein M (apoM) overexpression stimulates formation of larger apoM/sphingosine 1-phosphate-enriched plasma high density lipoprotein.

Liu M, Seo J, Allegood J, Bi X, Zhu X, Boudyguina E, Gebre AK, Avni D, Shah D, Sorci-Thomas MG, Thomas MJ, Shelness GS, Spiegel S, Parks JS.

J Biol Chem. 2014 Jan 31;289(5):2801-14. doi: 10.1074/jbc.M113.499913. Epub 2013 Dec 6.


HDL-bound sphingosine 1-phosphate acts as a biased agonist for the endothelial cell receptor S1P1 to limit vascular inflammation.

Galvani S, Sanson M, Blaho VA, Swendeman SL, Obinata H, Conger H, Dahlbäck B, Kono M, Proia RL, Smith JD, Hla T.

Sci Signal. 2015 Aug 11;8(389):ra79. doi: 10.1126/scisignal.aaa2581. Erratum in: Sci Signal. 2015 Oct 27;8(400):er8. Obinata, Hideru [added].


HDL-bound sphingosine-1-phosphate restrains lymphopoiesis and neuroinflammation.

Blaho VA, Galvani S, Engelbrecht E, Liu C, Swendeman SL, Kono M, Proia RL, Steinman L, Han MH, Hla T.

Nature. 2015 Jul 16;523(7560):342-6. doi: 10.1038/nature14462. Epub 2015 Jun 8.


Induction of insulin secretion by apolipoprotein M, a carrier for sphingosine 1-phosphate.

Kurano M, Hara M, Tsuneyama K, Sakoda H, Shimizu T, Tsukamoto K, Ikeda H, Yatomi Y.

Biochim Biophys Acta. 2014 Sep;1841(9):1217-26. doi: 10.1016/j.bbalip.2014.05.002. Epub 2014 May 9.


Uncleaved ApoM signal peptide is required for formation of large ApoM/sphingosine 1-phosphate (S1P)-enriched HDL particles.

Liu M, Allegood J, Zhu X, Seo J, Gebre AK, Boudyguina E, Cheng D, Chuang CC, Shelness GS, Spiegel S, Parks JS.

J Biol Chem. 2015 Mar 20;290(12):7861-70. doi: 10.1074/jbc.M114.631101. Epub 2015 Jan 27.


Liver involvement in sphingosine 1-phosphate dynamism revealed by adenoviral hepatic overexpression of apolipoprotein M.

Kurano M, Tsukamoto K, Ohkawa R, Hara M, Iino J, Kageyama Y, Ikeda H, Yatomi Y.

Atherosclerosis. 2013 Jul;229(1):102-9. doi: 10.1016/j.atherosclerosis.2013.04.024. Epub 2013 Apr 28.


Endothelial lipase is a critical determinant of high-density lipoprotein-stimulated sphingosine 1-phosphate-dependent signaling in vascular endothelium.

Tatematsu S, Francis SA, Natarajan P, Rader DJ, Saghatelian A, Brown JD, Michel T, Plutzky J.

Arterioscler Thromb Vasc Biol. 2013 Aug;33(8):1788-94. doi: 10.1161/ATVBAHA.113.301300. Epub 2013 May 30.


Plasma levels of sphingosine-1-phosphate and apolipoprotein M in patients with monogenic disorders of HDL metabolism.

Karuna R, Park R, Othman A, Holleboom AG, Motazacker MM, Sutter I, Kuivenhoven JA, Rohrer L, Matile H, Hornemann T, Stoffel M, Rentsch KM, von Eckardstein A.

Atherosclerosis. 2011 Dec;219(2):855-63. doi: 10.1016/j.atherosclerosis.2011.08.049. Epub 2011 Sep 6.


High density lipoprotein-associated sphingosine 1-phosphate promotes endothelial barrier function.

Argraves KM, Gazzolo PJ, Groh EM, Wilkerson BA, Matsuura BS, Twal WO, Hammad SM, Argraves WS.

J Biol Chem. 2008 Sep 5;283(36):25074-81. doi: 10.1074/jbc.M801214200. Epub 2008 Jul 7.


Apolipoprotein M: bridging HDL and endothelial function.

Christoffersen C, Nielsen LB.

Curr Opin Lipidol. 2013 Aug;24(4):295-300. doi: 10.1097/MOL.0b013e328361f6ad. Review.


Sphingosine-1-phosphate reduces ischaemia-reperfusion injury by phosphorylating the gap junction protein Connexin43.

Morel S, Christoffersen C, Axelsen LN, Montecucco F, Rochemont V, Frias MA, Mach F, James RW, Naus CC, Chanson M, Lampe PD, Nielsen MS, Nielsen LB, Kwak BR.

Cardiovasc Res. 2016 Mar 1;109(3):385-96. doi: 10.1093/cvr/cvw004. Epub 2016 Jan 13.


High-Density Lipoprotein-Associated Apolipoprotein M Limits Endothelial Inflammation by Delivering Sphingosine-1-Phosphate to the Sphingosine-1-Phosphate Receptor 1.

Ruiz M, Frej C, Holmér A, Guo LJ, Tran S, Dahlbäck B.

Arterioscler Thromb Vasc Biol. 2017 Jan;37(1):118-129. doi: 10.1161/ATVBAHA.116.308435. Epub 2016 Nov 22.


Sphingosine 1-phosphate-induced mobilization of intracellular Ca2+ mediates rac activation and adherens junction assembly in endothelial cells.

Mehta D, Konstantoulaki M, Ahmmed GU, Malik AB.

J Biol Chem. 2005 Apr 29;280(17):17320-8. Epub 2005 Feb 22.


Apolipoprotein M in lipid metabolism and cardiometabolic diseases.

Borup A, Christensen PM, Nielsen LB, Christoffersen C.

Curr Opin Lipidol. 2015 Feb;26(1):48-55. doi: 10.1097/MOL.0000000000000142. Review.


LDL receptor and ApoE are involved in the clearance of ApoM-associated sphingosine 1-phosphate.

Kurano M, Tsukamoto K, Hara M, Ohkawa R, Ikeda H, Yatomi Y.

J Biol Chem. 2015 Jan 23;290(4):2477-88. doi: 10.1074/jbc.M114.596445. Epub 2014 Dec 12.


Quantification of sphingosine 1-phosphate by validated LC-MS/MS method revealing strong correlation with apolipoprotein M in plasma but not in serum due to platelet activation during blood coagulation.

Frej C, Andersson A, Larsson B, Guo LJ, Norström E, Happonen KE, Dahlbäck B.

Anal Bioanal Chem. 2015 Nov;407(28):8533-42. doi: 10.1007/s00216-015-9008-4. Epub 2015 Sep 16.


Resveratrol exerts a biphasic effect on apolipoprotein M.

Kurano M, Hara M, Nojiri T, Ikeda H, Tsukamoto K, Yatomi Y.

Br J Pharmacol. 2016 Jan;173(1):222-33. doi: 10.1111/bph.13360. Epub 2015 Nov 12.

Supplemental Content

Support Center