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Items: 1 to 20 of 167

1.

Structure, electronic properties and catalytic behaviour of an activity-enhancing CYP102A1 (P450(BM3)) variant.

Whitehouse CJ, Yang W, Yorke JA, Tufton HG, Ogilvie LC, Bell SG, Zhou W, Bartlam M, Rao Z, Wong LL.

Dalton Trans. 2011 Oct 28;40(40):10383-96. doi: 10.1039/c1dt10098j. Epub 2011 May 20.

PMID:
21603690
2.

Structural basis for the properties of two single-site proline mutants of CYP102A1 (P450BM3).

Whitehouse CJ, Yang W, Yorke JA, Rowlatt BC, Strong AJ, Blanford CF, Bell SG, Bartlam M, Wong LL, Rao Z.

Chembiochem. 2010 Dec 10;11(18):2549-56. doi: 10.1002/cbic.201000421.

PMID:
21110374
4.

A single mutation in cytochrome P450 BM3 induces the conformational rearrangement seen upon substrate binding in the wild-type enzyme.

Joyce MG, Girvan HM, Munro AW, Leys D.

J Biol Chem. 2004 May 28;279(22):23287-93. Epub 2004 Mar 12.

5.

A highly active single-mutation variant of P450BM3 (CYP102A1).

Whitehouse CJ, Bell SG, Yang W, Yorke JA, Blanford CF, Strong AJ, Morse EJ, Bartlam M, Rao Z, Wong LL.

Chembiochem. 2009 Jul 6;10(10):1654-6. doi: 10.1002/cbic.200900279.

PMID:
19492389
6.

Glutamate-haem ester bond formation is disfavoured in flavocytochrome P450 BM3: characterization of glutamate substitution mutants at the haem site of P450 BM3.

Girvan HM, Levy CW, Williams P, Fisher K, Cheesman MR, Rigby SE, Leys D, Munro AW.

Biochem J. 2010 Apr 14;427(3):455-66. doi: 10.1042/BJ20091603.

PMID:
20180779
7.

Novel haem co-ordination variants of flavocytochrome P450BM3.

Girvan HM, Toogood HS, Littleford RE, Seward HE, Smith WE, Ekanem IS, Leys D, Cheesman MR, Munro AW.

Biochem J. 2009 Jan 1;417(1):65-76. doi: 10.1042/BJ20081133.

PMID:
18721129
8.

Filling a hole in cytochrome P450 BM3 improves substrate binding and catalytic efficiency.

Huang WC, Westlake AC, Maréchal JD, Joyce MG, Moody PC, Roberts GC.

J Mol Biol. 2007 Oct 26;373(3):633-51. Epub 2007 Aug 21.

PMID:
17868686
9.

Oxygen activation and electron transfer in flavocytochrome P450 BM3.

Ost TW, Clark J, Mowat CG, Miles CS, Walkinshaw MD, Reid GA, Chapman SK, Daff S.

J Am Chem Soc. 2003 Dec 10;125(49):15010-20.

PMID:
14653735
10.

Roles of key active-site residues in flavocytochrome P450 BM3.

Noble MA, Miles CS, Chapman SK, Lysek DA, MacKay AC, Reid GA, Hanzlik RP, Munro AW.

Biochem J. 1999 Apr 15;339 ( Pt 2):371-9.

11.

Expression, purification, and characterization of Bacillus subtilis cytochromes P450 CYP102A2 and CYP102A3: flavocytochrome homologues of P450 BM3 from Bacillus megaterium.

Gustafsson MC, Roitel O, Marshall KR, Noble MA, Chapman SK, Pessegueiro A, Fulco AJ, Cheesman MR, von Wachenfeldt C, Munro AW.

Biochemistry. 2004 May 11;43(18):5474-87.

PMID:
15122913
12.

Molecular dynamics simulations of P450 BM3--examination of substrate-induced conformational change.

Chang YT, Loew GH.

J Biomol Struct Dyn. 1999 Jun;16(6):1189-203.

PMID:
10447203
13.

P450(BM3) (CYP102A1): connecting the dots.

Whitehouse CJ, Bell SG, Wong LL.

Chem Soc Rev. 2012 Feb 7;41(3):1218-60. doi: 10.1039/c1cs15192d. Epub 2011 Oct 18. Review.

PMID:
22008827
14.

P450(BM3) on steroids: the Swiss Army knife P450 enzyme just gets better.

Wong LL.

Chembiochem. 2011 Nov 25;12(17):2537-9. doi: 10.1002/cbic.201100606. Epub 2011 Oct 13.

PMID:
21998091
15.

Desaturation of alkylbenzenes by cytochrome P450(BM3) (CYP102A1).

Whitehouse CJ, Bell SG, Wong LL.

Chemistry. 2008;14(35):10905-8. doi: 10.1002/chem.200801927. No abstract available.

PMID:
19003834
16.

Flavocytochrome P450 BM3 mutant A264E undergoes substrate-dependent formation of a novel heme iron ligand set.

Girvan HM, Marshall KR, Lawson RJ, Leys D, Joyce MG, Clarkson J, Smith WE, Cheesman MR, Munro AW.

J Biol Chem. 2004 May 28;279(22):23274-86. Epub 2004 Mar 12.

17.

The effect of mutation of F87 on the properties of CYP102A1-CYP4C7 chimeras: altered regiospecificity and substrate selectivity.

Chen CK, Shokhireva TKh, Berry RE, Zhang H, Walker FA.

J Biol Inorg Chem. 2008 Jun;13(5):813-24. doi: 10.1007/s00775-008-0368-5. Epub 2008 Apr 8.

PMID:
18392864
18.

Key mutations alter the cytochrome P450 BM3 conformational landscape and remove inherent substrate bias.

Butler CF, Peet C, Mason AE, Voice MW, Leys D, Munro AW.

J Biol Chem. 2013 Aug 30;288(35):25387-99. doi: 10.1074/jbc.M113.479717. Epub 2013 Jul 3.

19.

Rational design of a minimal and highly enriched CYP102A1 mutant library with improved regio-, stereo- and chemoselectivity.

Seifert A, Vomund S, Grohmann K, Kriening S, Urlacher VB, Laschat S, Pleiss J.

Chembiochem. 2009 Mar 23;10(5):853-61. doi: 10.1002/cbic.200800799. Erratum in: Chembiochem. 2009 Jun 15;10(9):1426.

PMID:
19222039
20.

Obligatory intermolecular electron-transfer from FAD to FMN in dimeric P450BM-3.

Kitazume T, Haines DC, Estabrook RW, Chen B, Peterson JA.

Biochemistry. 2007 Oct 23;46(42):11892-901. Epub 2007 Sep 29.

PMID:
17902705

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