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L3MBTL2 protein acts in concert with PcG protein-mediated monoubiquitination of H2A to establish a repressive chromatin structure.

Trojer P, Cao AR, Gao Z, Li Y, Zhang J, Xu X, Li G, Losson R, Erdjument-Bromage H, Tempst P, Farnham PJ, Reinberg D.

Mol Cell. 2011 May 20;42(4):438-50. doi: 10.1016/j.molcel.2011.04.004.


SUMOylation of the polycomb group protein L3MBTL2 facilitates repression of its target genes.

Stielow C, Stielow B, Finkernagel F, Scharfe M, Jarek M, Suske G.

Nucleic Acids Res. 2014 Mar;42(5):3044-58. doi: 10.1093/nar/gkt1317. Epub 2013 Dec 24.


Role of histone H2A ubiquitination in Polycomb silencing.

Wang H, Wang L, Erdjument-Bromage H, Vidal M, Tempst P, Jones RS, Zhang Y.

Nature. 2004 Oct 14;431(7010):873-8. Epub 2004 Sep 22.


The polycomb group protein L3mbtl2 assembles an atypical PRC1-family complex that is essential in pluripotent stem cells and early development.

Qin J, Whyte WA, Anderssen E, Apostolou E, Chen HH, Akbarian S, Bronson RT, Hochedlinger K, Ramaswamy S, Young RA, Hock H.

Cell Stem Cell. 2012 Sep 7;11(3):319-32. doi: 10.1016/j.stem.2012.06.002. Epub 2012 Jul 5.


MGA, L3MBTL2 and E2F6 determine genomic binding of the non-canonical Polycomb repressive complex PRC1.6.

Stielow B, Finkernagel F, Stiewe T, Nist A, Suske G.

PLoS Genet. 2018 Jan 30;14(1):e1007193. doi: 10.1371/journal.pgen.1007193. eCollection 2018 Jan.


MAPKAP kinase 3pK phosphorylates and regulates chromatin association of the polycomb group protein Bmi1.

Voncken JW, Niessen H, Neufeld B, Rennefahrt U, Dahlmans V, Kubben N, Holzer B, Ludwig S, Rapp UR.

J Biol Chem. 2005 Feb 18;280(7):5178-87. Epub 2004 Nov 24.


H2A monoubiquitination in Arabidopsis thaliana is generally independent of LHP1 and PRC2 activity.

Zhou Y, Romero-Campero FJ, Gómez-Zambrano Á, Turck F, Calonje M.

Genome Biol. 2017 Apr 12;18(1):69. doi: 10.1186/s13059-017-1197-z.


Histone H2A deubiquitinase activity of the Polycomb repressive complex PR-DUB.

Scheuermann JC, de Ayala Alonso AG, Oktaba K, Ly-Hartig N, McGinty RK, Fraterman S, Wilm M, Muir TW, Müller J.

Nature. 2010 May 13;465(7295):243-7. doi: 10.1038/nature08966. Epub 2010 May 2.


The malignant brain tumor (MBT) domain protein SFMBT1 is an integral histone reader subunit of the LSD1 demethylase complex for chromatin association and epithelial-to-mesenchymal transition.

Tang M, Shen H, Jin Y, Lin T, Cai Q, Pinard MA, Biswas S, Tran Q, Li G, Shenoy AK, Tongdee E, Lin S, Gu Y, Law BK, Zhou L, McKenna R, Wu L, Lu J.

J Biol Chem. 2013 Sep 20;288(38):27680-91. doi: 10.1074/jbc.M113.482349. Epub 2013 Aug 8.


The role of the histone H2A ubiquitinase Sce in Polycomb repression.

Gutiérrez L, Oktaba K, Scheuermann JC, Gambetta MC, Ly-Hartig N, Müller J.

Development. 2012 Jan;139(1):117-27. doi: 10.1242/dev.074450. Epub 2011 Nov 17.


Methylation-state-specific recognition of histones by the MBT repeat protein L3MBTL2.

Guo Y, Nady N, Qi C, Allali-Hassani A, Zhu H, Pan P, Adams-Cioaba MA, Amaya MF, Dong A, Vedadi M, Schapira M, Read RJ, Arrowsmith CH, Min J.

Nucleic Acids Res. 2009 Apr;37(7):2204-10. doi: 10.1093/nar/gkp086. Epub 2009 Feb 20.


Polycomb group protein-associated chromatin is reproduced in post-mitotic G1 phase and is required for S phase progression.

Aoto T, Saitoh N, Sakamoto Y, Watanabe S, Nakao M.

J Biol Chem. 2008 Jul 4;283(27):18905-15. doi: 10.1074/jbc.M709322200. Epub 2008 May 2.


Histone H2A monoubiquitination and Polycomb repression: the missing pieces of the puzzle.

Scheuermann JC, Gutiérrez L, Müller J.

Fly (Austin). 2012 Jul-Sep;6(3):162-8. doi: 10.4161/fly.20986. Epub 2012 Jul 1.


The polycomb group protein BMI1 is a transcriptional target of HDAC inhibitors.

Bommi PV, Dimri M, Sahasrabuddhe AA, Khandekar J, Dimri GP.

Cell Cycle. 2010 Jul 1;9(13):2663-73.


Structural studies of a four-MBT repeat protein MBTD1.

Eryilmaz J, Pan P, Amaya MF, Allali-Hassani A, Dong A, Adams-Cioaba MA, Mackenzie F, Vedadi M, Min J.

PLoS One. 2009 Oct 20;4(10):e7274. doi: 10.1371/journal.pone.0007274.


A novel repressive E2F6 complex containing the polycomb group protein, EPC1, that interacts with EZH2 in a proliferation-specific manner.

Attwooll C, Oddi S, Cartwright P, Prosperini E, Agger K, Steensgaard P, Wagener C, Sardet C, Moroni MC, Helin K.

J Biol Chem. 2005 Jan 14;280(2):1199-208. Epub 2004 Nov 8.


Genome-wide uH2A localization analysis highlights Bmi1-dependent deposition of the mark at repressed genes.

Kallin EM, Cao R, Jothi R, Xia K, Cui K, Zhao K, Zhang Y.

PLoS Genet. 2009 Jun;5(6):e1000506. doi: 10.1371/journal.pgen.1000506. Epub 2009 Jun 5.


Molecular recognition of histone lysine methylation by the Polycomb group repressor dSfmbt.

Grimm C, Matos R, Ly-Hartig N, Steuerwald U, Lindner D, Rybin V, Müller J, Müller CW.

EMBO J. 2009 Jul 8;28(13):1965-77. doi: 10.1038/emboj.2009.147. Epub 2009 Jun 4.


Role of remodeling and spacing factor 1 in histone H2A ubiquitination-mediated gene silencing.

Zhang Z, Jones AE, Wu W, Kim J, Kang Y, Bi X, Gu Y, Popov IK, Renfrow MB, Vassylyeva MN, Vassylyev DG, Giles KE, Chen D, Kumar A, Fan Y, Tong Y, Liu CF, An W, Chang C, Luo J, Chow LT, Wang H.

Proc Natl Acad Sci U S A. 2017 Sep 19;114(38):E7949-E7958. doi: 10.1073/pnas.1711158114. Epub 2017 Aug 30.


Interaction proteomics analysis of polycomb proteins defines distinct PRC1 complexes in mammalian cells.

Vandamme J, Völkel P, Rosnoblet C, Le Faou P, Angrand PO.

Mol Cell Proteomics. 2011 Apr;10(4):M110.002642. doi: 10.1074/mcp.M110.002642. Epub 2011 Jan 31.

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