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Items: 1 to 20 of 104


Genetic reduction of insulin-like growth factor-1 mimics the anticancer effects of calorie restriction on cyclooxygenase-2-driven pancreatic neoplasia.

Lashinger LM, Malone LM, McArthur MJ, Goldberg JA, Daniels EA, Pavone A, Colby JK, Smith NC, Perkins SN, Fischer SM, Hursting SD.

Cancer Prev Res (Phila). 2011 Jul;4(7):1030-40. doi: 10.1158/1940-6207.CAPR-11-0027. Epub 2011 May 18.


Rapamycin partially mimics the anticancer effects of calorie restriction in a murine model of pancreatic cancer.

Lashinger LM, Malone LM, Brown GW, Daniels EA, Goldberg JA, Otto G, Fischer SM, Hursting SD.

Cancer Prev Res (Phila). 2011 Jul;4(7):1041-51. doi: 10.1158/1940-6207.CAPR-11-0023. Epub 2011 May 18.


Calorie restriction decreases murine and human pancreatic tumor cell growth, nuclear factor-κB activation, and inflammation-related gene expression in an insulin-like growth factor-1-dependent manner.

Harvey AE, Lashinger LM, Hays D, Harrison LM, Lewis K, Fischer SM, Hursting SD.

PLoS One. 2014 May 7;9(5):e94151. doi: 10.1371/journal.pone.0094151. eCollection 2014.


Dose-dependent effects of calorie restriction on gene expression, metabolism, and tumor progression are partially mediated by insulin-like growth factor-1.

Nogueira LM, Lavigne JA, Chandramouli GV, Lui H, Barrett JC, Hursting SD.

Cancer Med. 2012 Oct;1(2):275-88. doi: 10.1002/cam4.23. Epub 2012 Aug 6.


Dietary energy balance modulation of Kras- and Ink4a/Arf+/--driven pancreatic cancer: the role of insulin-like growth factor-I.

Lashinger LM, Harrison LM, Rasmussen AJ, Logsdon CD, Fischer SM, McArthur MJ, Hursting SD.

Cancer Prev Res (Phila). 2013 Oct;6(10):1046-55. doi: 10.1158/1940-6207.CAPR-13-0185. Epub 2013 Aug 26.


Decreased systemic IGF-1 in response to calorie restriction modulates murine tumor cell growth, nuclear factor-κB activation, and inflammation-related gene expression.

Harvey AE, Lashinger LM, Otto G, Nunez NP, Hursting SD.

Mol Carcinog. 2013 Dec;52(12):997-1006. doi: 10.1002/mc.21940. Epub 2012 Jul 6.


IGF1 dependence of dietary energy balance effects on murine Met1 mammary tumor progression, epithelial-to-mesenchymal transition, and chemokine expression.

Ford NA, Nunez NP, Holcomb VB, Hursting SD.

Endocr Relat Cancer. 2013 Jan 21;20(1):39-51. doi: 10.1530/ERC-12-0329. Print 2013 Feb.


Metformin prevents aggressive ovarian cancer growth driven by high-energy diet: similarity with calorie restriction.

Al-Wahab Z, Mert I, Tebbe C, Chhina J, Hijaz M, Morris RT, Ali-Fehmi R, Giri S, Munkarah AR, Rattan R.

Oncotarget. 2015 May 10;6(13):10908-23.


Energy balance modulates mouse skin tumor promotion through altered IGF-1R and EGFR crosstalk.

Moore T, Beltran L, Carbajal S, Hursting SD, DiGiovanni J.

Cancer Prev Res (Phila). 2012 Oct;5(10):1236-46. doi: 10.1158/1940-6207.CAPR-12-0234. Epub 2012 Aug 15.


The enhancing effects of obesity on mammary tumor growth and Akt/mTOR pathway activation persist after weight loss and are reversed by RAD001.

De Angel RE, Conti CJ, Wheatley KE, Brenner AJ, Otto G, Degraffenried LA, Hursting SD.

Mol Carcinog. 2013 Jun;52(6):446-58. doi: 10.1002/mc.21878. Epub 2012 Jan 30.


Long-lived growth hormone receptor knockout mice: interaction of reduced insulin-like growth factor i/insulin signaling and caloric restriction.

Al-Regaiey KA, Masternak MM, Bonkowski M, Sun L, Bartke A.

Endocrinology. 2005 Feb;146(2):851-60. Epub 2004 Oct 21.


Calorie restriction delays the progression of lesions to pancreatic cancer in the LSL-KrasG12D; Pdx-1/Cre mouse model of pancreatic cancer.

Lanza-Jacoby S, Yan G, Radice G, LePhong C, Baliff J, Hess R.

Exp Biol Med (Maywood). 2013 Jul;238(7):787-97. doi: 10.1177/1535370213493727. Epub 2013 Jul 4.


Urothelial overexpression of insulin-like growth factor-1 increases susceptibility to p-cresidine-induced bladder carcinogenesis in transgenic mice.

Hursting SD, Perkins SN, Lavigne JA, Beltran L, Haines DC, Hill HL, Alvord WG, Barrett JC, DiGiovanni J.

Mol Carcinog. 2009 Aug;48(8):671-7. doi: 10.1002/mc.20548.


Reduced susceptibility to two-stage skin carcinogenesis in mice with low circulating insulin-like growth factor I levels.

Moore T, Carbajal S, Beltran L, Perkins SN, Yakar S, Leroith D, Hursting SD, Digiovanni J.

Cancer Res. 2008 May 15;68(10):3680-8. doi: 10.1158/0008-5472.CAN-07-6271.


Constitutive expression of insulin-like growth factor-1 in epidermal basal cells of transgenic mice leads to spontaneous tumor promotion.

DiGiovanni J, Bol DK, Wilker E, Beltrán L, Carbajal S, Moats S, Ramirez A, Jorcano J, Kiguchi K.

Cancer Res. 2000 Mar 15;60(6):1561-70.


Murine osteosarcoma primary tumour growth and metastatic progression is maintained after marked suppression of serum insulin-like growth factor I.

Hong SH, Briggs J, Newman R, Hoffman K, Mendoza A, LeRoith D, Helman L, Yakar S, Khanna C.

Int J Cancer. 2009 May 1;124(9):2042-9. doi: 10.1002/ijc.24169.


Nicotine promotes initiation and progression of KRAS-induced pancreatic cancer via Gata6-dependent dedifferentiation of acinar cells in mice.

Hermann PC, Sancho P, Cañamero M, Martinelli P, Madriles F, Michl P, Gress T, de Pascual R, Gandia L, Guerra C, Barbacid M, Wagner M, Vieira CR, Aicher A, Real FX, Sainz B Jr, Heeschen C.

Gastroenterology. 2014 Nov;147(5):1119-33.e4. doi: 10.1053/j.gastro.2014.08.002. Epub 2014 Aug 12.


Effects of calorie restriction and diet-induced obesity on murine colon carcinogenesis, growth and inflammatory factors, and microRNA expression.

Olivo-Marston SE, Hursting SD, Perkins SN, Schetter A, Khan M, Croce C, Harris CC, Lavigne J.

PLoS One. 2014 Apr 14;9(4):e94765. doi: 10.1371/journal.pone.0094765. eCollection 2014.


Calorie restriction minimizes activation of insulin signaling in response to glucose: potential involvement of the growth hormone-insulin-like growth factor 1 axis.

Hayashi H, Yamaza H, Komatsu T, Park S, Chiba T, Higami Y, Nagayasu T, Shimokawa I.

Exp Gerontol. 2008 Sep;43(9):827-32. doi: 10.1016/j.exger.2008.05.011. Epub 2008 Jun 10.


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