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The Saccharomyces cerevisiae telomerase subunit Est3 binds telomeres in a cell cycle- and Est1-dependent manner and interacts directly with Est1 in vitro.

Tuzon CT, Wu Y, Chan A, Zakian VA.

PLoS Genet. 2011 May;7(5):e1002060. doi: 10.1371/journal.pgen.1002060. Epub 2011 May 5.


The principal role of Ku in telomere length maintenance is promotion of Est1 association with telomeres.

Williams JM, Ouenzar F, Lemon LD, Chartrand P, Bertuch AA.

Genetics. 2014 Aug;197(4):1123-36. doi: 10.1534/genetics.114.164707. Epub 2014 May 30.


Regulated assembly and disassembly of the yeast telomerase quaternary complex.

Tucey TM, Lundblad V.

Genes Dev. 2014 Oct 1;28(19):2077-89. doi: 10.1101/gad.246256.114. Epub 2014 Sep 19.


The Est3 protein is a subunit of yeast telomerase.

Hughes TR, Evans SK, Weilbaecher RG, Lundblad V.

Curr Biol. 2000 Jun 29;10(13):809-12.


Regulation of telomerase by telomeric proteins.

Smogorzewska A, de Lange T.

Annu Rev Biochem. 2004;73:177-208. Review.


The TPR-containing domain within Est1 homologs exhibits species-specific roles in telomerase interaction and telomere length homeostasis.

Sealey DC, Kostic AD, LeBel C, Pryde F, Harrington L.

BMC Mol Biol. 2011 Oct 18;12:45. doi: 10.1186/1471-2199-12-45.


The interaction between the yeast telomerase RNA and the Est1 protein requires three structural elements.

Lubin JW, Tucey TM, Lundblad V.

RNA. 2012 Sep;18(9):1597-604. doi: 10.1261/rna.034447.112. Epub 2012 Jul 30.


Senescence mutants of Saccharomyces cerevisiae with a defect in telomere replication identify three additional EST genes.

Lendvay TS, Morris DK, Sah J, Balasubramanian B, Lundblad V.

Genetics. 1996 Dec;144(4):1399-412.


Saccharomyces cerevisiae Est3p dimerizes in vitro and dimerization contributes to efficient telomere replication in vivo.

Yang CP, Chen YB, Meng FL, Zhou JQ.

Nucleic Acids Res. 2006 Jan 17;34(2):407-16. Print 2006.


The telomeric Cdc13 protein interacts directly with the telomerase subunit Est1 to bring it to telomeric DNA ends in vitro.

Wu Y, Zakian VA.

Proc Natl Acad Sci U S A. 2011 Dec 20;108(51):20362-9. doi: 10.1073/pnas.1100281108. Epub 2011 Oct 3.


A yeast telomerase complex containing the Est1 recruitment protein is assembled early in the cell cycle.

Tucey TM, Lundblad V.

Biochemistry. 2013 Feb 19;52(7):1131-3. doi: 10.1021/bi3015218. Epub 2013 Feb 7. Erratum in: Biochemistry. 2013 Jul 23;52(29):5027.


Three Ever Shorter Telomere (EST) genes are dispensable for in vitro yeast telomerase activity.

Lingner J, Cech TR, Hughes TR, Lundblad V.

Proc Natl Acad Sci U S A. 1997 Oct 14;94(21):11190-5.


A second essential function of the Est1-binding arm of yeast telomerase RNA.

Lebo KJ, Niederer RO, Zappulla DC.

RNA. 2015 May;21(5):862-76. doi: 10.1261/rna.049379.114. Epub 2015 Mar 3.


Two pathways recruit telomerase to Saccharomyces cerevisiae telomeres.

Chan A, Boulé JB, Zakian VA.

PLoS Genet. 2008 Oct;4(10):e1000236. doi: 10.1371/journal.pgen.1000236. Epub 2008 Oct 24.


SGS1 is required for telomere elongation in the absence of telomerase.

Huang P, Pryde FE, Lester D, Maddison RL, Borts RH, Hickson ID, Louis EJ.

Curr Biol. 2001 Jan 23;11(2):125-9.


Stiffened yeast telomerase RNA supports RNP function in vitro and in vivo.

Lebo KJ, Zappulla DC.

RNA. 2012 Sep;18(9):1666-78. doi: 10.1261/rna.033555.112. Epub 2012 Jul 31.


Yeast telomerase protein Est3 is a novel type of GTPase.

Shubernetskaya O, Logvina N, Sharanov Y, Zvereva M.

Biochimie. 2011 Feb;93(2):202-6. doi: 10.1016/j.biochi.2010.09.013. Epub 2010 Sep 25.


RNase III-dependent regulation of yeast telomerase.

Larose S, Laterreur N, Ghazal G, Gagnon J, Wellinger RJ, Elela SA.

J Biol Chem. 2007 Feb 16;282(7):4373-81. Epub 2006 Dec 11.


Stimulation of yeast telomerase activity by the ever shorter telomere 3 (Est3) subunit is dependent on direct interaction with the catalytic protein Est2.

Talley JM, DeZwaan DC, Maness LD, Freeman BC, Friedman KL.

J Biol Chem. 2011 Jul 29;286(30):26431-9. doi: 10.1074/jbc.M111.228635. Epub 2011 Jun 9.

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