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Items: 1 to 20 of 250

1.

Toll-like receptor-mediated inflammatory signaling reprograms cardiac energy metabolism by repressing peroxisome proliferator-activated receptor γ coactivator-1 signaling.

Schilling J, Lai L, Sambandam N, Dey CE, Leone TC, Kelly DP.

Circ Heart Fail. 2011 Jul;4(4):474-82. doi: 10.1161/CIRCHEARTFAILURE.110.959833. Epub 2011 May 10.

2.
3.

Suppression of mitochondrial biogenesis through toll-like receptor 4-dependent mitogen-activated protein kinase kinase/extracellular signal-regulated kinase signaling in endotoxin-induced acute kidney injury.

Smith JA, Stallons LJ, Collier JB, Chavin KD, Schnellmann RG.

J Pharmacol Exp Ther. 2015 Feb;352(2):346-57. doi: 10.1124/jpet.114.221085. Epub 2014 Dec 12.

5.

Cardiac lipin 1 expression is regulated by the peroxisome proliferator activated receptor γ coactivator 1α/estrogen related receptor axis.

Mitra MS, Schilling JD, Wang X, Jay PY, Huss JM, Su X, Finck BN.

J Mol Cell Cardiol. 2011 Jul;51(1):120-8. doi: 10.1016/j.yjmcc.2011.04.009. Epub 2011 Apr 28.

6.

AMP activated protein kinase-α2 regulates expression of estrogen-related receptor-α, a metabolic transcription factor related to heart failure development.

Hu X, Xu X, Lu Z, Zhang P, Fassett J, Zhang Y, Xin Y, Hall JL, Viollet B, Bache RJ, Huang Y, Chen Y.

Hypertension. 2011 Oct;58(4):696-703. doi: 10.1161/HYPERTENSIONAHA.111.174128. Epub 2011 Aug 8.

7.

The transcriptional coactivator PGC-1alpha is essential for maximal and efficient cardiac mitochondrial fatty acid oxidation and lipid homeostasis.

Lehman JJ, Boudina S, Banke NH, Sambandam N, Han X, Young DM, Leone TC, Gross RW, Lewandowski ED, Abel ED, Kelly DP.

Am J Physiol Heart Circ Physiol. 2008 Jul;295(1):H185-96. doi: 10.1152/ajpheart.00081.2008. Epub 2008 May 16.

8.

Toll-like receptor 4, nitric oxide, and myocardial depression in endotoxemia.

Baumgarten G, Knuefermann P, Schuhmacher G, Vervölgyi V, von Rappard J, Dreiner U, Fink K, Djoufack C, Hoeft A, Grohé C, Knowlton AA, Meyer R.

Shock. 2006 Jan;25(1):43-9.

PMID:
16369185
9.

Innate immune signaling induces expression and shedding of the heparan sulfate proteoglycan syndecan-4 in cardiac fibroblasts and myocytes, affecting inflammation in the pressure-overloaded heart.

Strand ME, Herum KM, Rana ZA, Skrbic B, Askevold ET, Dahl CP, Vistnes M, Hasic A, Kvaløy H, Sjaastad I, Carlson CR, Tønnessen T, Gullestad L, Christensen G, Lunde IG.

FEBS J. 2013 May;280(10):2228-47. doi: 10.1111/febs.12161. Epub 2013 Feb 24.

10.

Astragaloside IV protects against isoproterenol-induced cardiac hypertrophy by regulating NF-κB/PGC-1α signaling mediated energy biosynthesis.

Zhang S, Tang F, Yang Y, Lu M, Luan A, Zhang J, Yang J, Wang H.

PLoS One. 2015 Mar 4;10(3):e0118759. doi: 10.1371/journal.pone.0118759. eCollection 2015.

11.

TNF-alpha reduces PGC-1alpha expression through NF-kappaB and p38 MAPK leading to increased glucose oxidation in a human cardiac cell model.

Palomer X, Alvarez-Guardia D, Rodríguez-Calvo R, Coll T, Laguna JC, Davidson MM, Chan TO, Feldman AM, Vázquez-Carrera M.

Cardiovasc Res. 2009 Mar 1;81(4):703-12. doi: 10.1093/cvr/cvn327. Epub 2008 Nov 27.

PMID:
19038972
12.

An overview of the crosstalk between inflammatory processes and metabolic dysregulation during diabetic cardiomyopathy.

Palomer X, Salvadó L, Barroso E, Vázquez-Carrera M.

Int J Cardiol. 2013 Oct 9;168(4):3160-72. doi: 10.1016/j.ijcard.2013.07.150. Epub 2013 Aug 6. Review.

PMID:
23932046
13.

A role for peroxisome proliferator-activated receptor γ coactivator-1 in the control of mitochondrial dynamics during postnatal cardiac growth.

Martin OJ, Lai L, Soundarapandian MM, Leone TC, Zorzano A, Keller MP, Attie AD, Muoio DM, Kelly DP.

Circ Res. 2014 Feb 14;114(4):626-36. doi: 10.1161/CIRCRESAHA.114.302562. Epub 2013 Dec 23.

14.

Nuclear receptor signaling and cardiac energetics.

Huss JM, Kelly DP.

Circ Res. 2004 Sep 17;95(6):568-78. Review.

15.

Induction of heart failure by minimally invasive aortic constriction in mice: reduced peroxisome proliferator-activated receptor γ coactivator levels and mitochondrial dysfunction.

Faerber G, Barreto-Perreia F, Schoepe M, Gilsbach R, Schrepper A, Schwarzer M, Mohr FW, Hein L, Doenst T.

J Thorac Cardiovasc Surg. 2011 Feb;141(2):492-500, 500.e1. doi: 10.1016/j.jtcvs.2010.03.029. Epub 2010 May 5.

16.

Toll4 (TLR4) expression in cardiac myocytes in normal and failing myocardium.

Frantz S, Kobzik L, Kim YD, Fukazawa R, Medzhitov R, Lee RT, Kelly RA.

J Clin Invest. 1999 Aug;104(3):271-80.

17.

Dietary fat supply to failing hearts determines dynamic lipid signaling for nuclear receptor activation and oxidation of stored triglyceride.

Lahey R, Wang X, Carley AN, Lewandowski ED.

Circulation. 2014 Nov 11;130(20):1790-9. doi: 10.1161/CIRCULATIONAHA.114.011687. Epub 2014 Sep 29.

18.

Cardiac-specific induction of the transcriptional coactivator peroxisome proliferator-activated receptor gamma coactivator-1alpha promotes mitochondrial biogenesis and reversible cardiomyopathy in a developmental stage-dependent manner.

Russell LK, Mansfield CM, Lehman JJ, Kovacs A, Courtois M, Saffitz JE, Medeiros DM, Valencik ML, McDonald JA, Kelly DP.

Circ Res. 2004 Mar 5;94(4):525-33. Epub 2004 Jan 15.

19.

Immune cell Toll-like receptor 4 is required for cardiac myocyte impairment during endotoxemia.

Tavener SA, Long EM, Robbins SM, McRae KM, Van Remmen H, Kubes P.

Circ Res. 2004 Oct 1;95(7):700-7. Epub 2004 Sep 9.

20.

Atorvastatin prevents peroxisome proliferator-activated receptor gamma coactivator-1 (PGC-1) downregulation in lipopolysaccharide-stimulated H9c2 cells.

Planavila A, Sánchez RM, Merlos M, Laguna JC, Vázquez-Carrera M.

Biochim Biophys Acta. 2005 Sep 15;1736(2):120-7.

PMID:
16139565

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