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Items: 1 to 20 of 168

1.

Induction of hypoxia inducible factor (HIF-1α) in rat kidneys by iron chelation with the hydroxypyridinone, CP94.

Baek JH, Reiter CE, Manalo DJ, Buehler PW, Hider RC, Alayash AI.

Biochim Biophys Acta. 2011 Apr-Jun;1809(4-6):262-8. doi: 10.1016/j.bbagrm.2011.04.010. Epub 2011 May 1.

PMID:
21558026
2.

Intermediary metabolite precursor dimethyl-2-ketoglutarate stabilizes hypoxia-inducible factor-1α by inhibiting prolyl-4-hydroxylase PHD2.

Hou P, Kuo CY, Cheng CT, Liou JP, Ann DK, Chen Q.

PLoS One. 2014 Nov 24;9(11):e113865. doi: 10.1371/journal.pone.0113865. eCollection 2014.

3.

Inactivation of prolyl hydroxylase domain (PHD) protein by epigallocatechin (EGCG) stabilizes hypoxia-inducible factor (HIF-1α) and induces hepcidin (Hamp) in rat kidney.

Manalo DJ, Baek JH, Buehler PW, Struble E, Abraham B, Alayash AI.

Biochem Biophys Res Commun. 2011 Dec 16;416(3-4):421-6. doi: 10.1016/j.bbrc.2011.11.085. Epub 2011 Nov 25.

PMID:
22138393
4.

Nitric oxide reverses desferrioxamine- and hypoxia-evoked HIF-1alpha accumulation--implications for prolyl hydroxylase activity and iron.

Callapina M, Zhou J, Schnitzer S, Metzen E, Lohr C, Deitmer JW, Brüne B.

Exp Cell Res. 2005 May 15;306(1):274-84. Epub 2005 Mar 20.

PMID:
15878351
5.

Endothelin-1 inhibits prolyl hydroxylase domain 2 to activate hypoxia-inducible factor-1alpha in melanoma cells.

Spinella F, Rosanò L, Del Duca M, Di Castro V, Nicotra MR, Natali PG, Bagnato A.

PLoS One. 2010 Jun 21;5(6):e11241. doi: 10.1371/journal.pone.0011241.

6.
7.

Differential in vitro and cellular effects of iron chelators for hypoxia inducible factor hydroxylases.

Cho EA, Song HK, Lee SH, Chung BH, Lim HM, Lee MK.

J Cell Biochem. 2013 Apr;114(4):864-73. doi: 10.1002/jcb.24423.

PMID:
23097160
8.

The protective effect of prolyl-hydroxylase inhibition against renal ischaemia requires application prior to ischaemia but is superior to EPO treatment.

Wang Z, Schley G, Türkoglu G, Burzlaff N, Amann KU, Willam C, Eckardt KU, Bernhardt WM.

Nephrol Dial Transplant. 2012 Mar;27(3):929-36. doi: 10.1093/ndt/gfr379. Epub 2011 Jul 8.

PMID:
21742784
9.

DHEA decreases HIF-1alpha accumulation under hypoxia in human pulmonary artery cells: potential role in the treatment of pulmonary arterial hypertension.

Dessouroux A, Akwa Y, Baulieu EE.

J Steroid Biochem Mol Biol. 2008 Mar;109(1-2):81-9. doi: 10.1016/j.jsbmb.2007.12.001. Epub 2007 Dec 7.

PMID:
18261897
10.

Non-hypoxic stabilization of hypoxia-inducible factor alpha (HIF-alpha): relevance in neural progenitor/stem cells.

Milosevic J, Adler I, Manaenko A, Schwarz SC, Walkinshaw G, Arend M, Flippin LA, Storch A, Schwarz J.

Neurotox Res. 2009 May;15(4):367-80. doi: 10.1007/s12640-009-9043-z. Epub 2009 Mar 20.

PMID:
19384570
11.

Multiple factors affecting cellular redox status and energy metabolism modulate hypoxia-inducible factor prolyl hydroxylase activity in vivo and in vitro.

Pan Y, Mansfield KD, Bertozzi CC, Rudenko V, Chan DA, Giaccia AJ, Simon MC.

Mol Cell Biol. 2007 Feb;27(3):912-25. Epub 2006 Nov 13.

12.

Src activates HIF-1α not through direct phosphorylation of HIF-1α specific prolyl-4 hydroxylase 2 but through activation of the NADPH oxidase/Rac pathway.

Lee HY, Lee T, Lee N, Yang EG, Lee C, Lee J, Moon EY, Ha J, Park H.

Carcinogenesis. 2011 May;32(5):703-12. doi: 10.1093/carcin/bgr034. Epub 2011 Feb 18.

PMID:
21335603
13.

Hypoxia-inducible factor prolyl-hydroxylase 2 senses high-salt intake to increase hypoxia inducible factor 1alpha levels in the renal medulla.

Wang Z, Zhu Q, Xia M, Li PL, Hinton SJ, Li N.

Hypertension. 2010 May;55(5):1129-36. doi: 10.1161/HYPERTENSIONAHA.109.145896. Epub 2010 Mar 22.

14.

Effects of hypoxia and intracellular iron chelation on hypoxia-inducible factor-1alpha and -1beta in the rat carotid body and glomus cells.

Baby SM, Roy A, Mokashi AM, Lahiri S.

Histochem Cell Biol. 2003 Nov;120(5):343-52. Epub 2003 Nov 5.

PMID:
14600837
15.

Erythropoietin inhibits HIF-1α expression via upregulation of PHD-2 transcription and translation in an in vitro model of hypoxia-ischemia.

Souvenir R, Flores JJ, Ostrowski RP, Manaenko A, Duris K, Tang J.

Transl Stroke Res. 2014 Feb;5(1):118-27. doi: 10.1007/s12975-013-0312-z. Epub 2013 Nov 27.

16.

Increased activation of the hypoxia-inducible factor pathway in varicose veins.

Lim CS, Kiriakidis S, Paleolog EM, Davies AH.

J Vasc Surg. 2012 May;55(5):1427-39. doi: 10.1016/j.jvs.2011.10.111. Epub 2012 Jan 24.

17.

Role of prolyl hydroxylation in oncogenically stabilized hypoxia-inducible factor-1alpha.

Chan DA, Sutphin PD, Denko NC, Giaccia AJ.

J Biol Chem. 2002 Oct 18;277(42):40112-7. Epub 2002 Aug 16.

18.

The antimycotic ciclopirox olamine induces HIF-1alpha stability, VEGF expression, and angiogenesis.

Linden T, Katschinski DM, Eckhardt K, Scheid A, Pagel H, Wenger RH.

FASEB J. 2003 Apr;17(6):761-3. Epub 2003 Feb 19.

PMID:
12594177
19.

Hinokitiol activates the hypoxia-inducible factor (HIF) pathway through inhibition of HIF hydroxylases.

Lee MJ, Kim JW, Yang EG.

Biochem Biophys Res Commun. 2010 May 28;396(2):370-5. doi: 10.1016/j.bbrc.2010.04.099. Epub 2010 Apr 21.

PMID:
20416277
20.

Nitric oxide modulates oxygen sensing by hypoxia-inducible factor 1-dependent induction of prolyl hydroxylase 2.

Berchner-Pfannschmidt U, Yamac H, Trinidad B, Fandrey J.

J Biol Chem. 2007 Jan 19;282(3):1788-96. Epub 2006 Oct 23.

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