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Items: 1 to 20 of 109

1.

The 2'-OH group of the peptidyl-tRNA stabilizes an active conformation of the ribosomal PTC.

Zaher HS, Shaw JJ, Strobel SA, Green R.

EMBO J. 2011 May 6;30(12):2445-53. doi: 10.1038/emboj.2011.142.

2.

A Role for the 2' OH of peptidyl-tRNA substrate in peptide release on the ribosome revealed through RF-mediated rescue.

Shaw JJ, Trobro S, He SL, Åqvist J, Green R.

Chem Biol. 2012 Aug 24;19(8):983-93. doi: 10.1016/j.chembiol.2012.06.011.

3.

Structure of the 70S ribosome bound to release factor 2 and a substrate analog provides insights into catalysis of peptide release.

Jin H, Kelley AC, Loakes D, Ramakrishnan V.

Proc Natl Acad Sci U S A. 2010 May 11;107(19):8593-8. doi: 10.1073/pnas.1003995107. Epub 2010 Apr 26.

4.

Peptide release on the ribosome depends critically on the 2' OH of the peptidyl-tRNA substrate.

Brunelle JL, Shaw JJ, Youngman EM, Green R.

RNA. 2008 Aug;14(8):1526-31. doi: 10.1261/rna.1057908. Epub 2008 Jun 20.

5.

Different substrate-dependent transition states in the active site of the ribosome.

Kuhlenkoetter S, Wintermeyer W, Rodnina MV.

Nature. 2011 Jul 31;476(7360):351-4. doi: 10.1038/nature10247.

PMID:
21804565
6.
7.

The mechanism of peptidyl transfer catalysis by the ribosome.

Leung EK, Suslov N, Tuttle N, Sengupta R, Piccirilli JA.

Annu Rev Biochem. 2011;80:527-55. doi: 10.1146/annurev-biochem-082108-165150. Review.

PMID:
21548786
8.

Base-pairing between 23S rRNA and tRNA in the ribosomal A site.

Kim DF, Green R.

Mol Cell. 1999 Nov;4(5):859-64.

9.

The ribosome can discriminate the chirality of amino acids within its peptidyl-transferase center.

Englander MT, Avins JL, Fleisher RC, Liu B, Effraim PR, Wang J, Schulten K, Leyh TS, Gonzalez RL Jr, Cornish VW.

Proc Natl Acad Sci U S A. 2015 May 12;112(19):6038-43. doi: 10.1073/pnas.1424712112. Epub 2015 Apr 27.

10.

Peptidyl-CCA deacylation on the ribosome promoted by induced fit and the O3'-hydroxyl group of A76 of the unacylated A-site tRNA.

Simonović M, Steitz TA.

RNA. 2008 Nov;14(11):2372-8. doi: 10.1261/rna.1118908. Epub 2008 Sep 25.

11.

Structural insights into the roles of water and the 2' hydroxyl of the P site tRNA in the peptidyl transferase reaction.

Schmeing TM, Huang KS, Kitchen DE, Strobel SA, Steitz TA.

Mol Cell. 2005 Nov 11;20(3):437-48.

12.

Ribosomal tRNA binding sites: three-site models of translation.

Burkhardt N, Jünemann R, Spahn CM, Nierhaus KH.

Crit Rev Biochem Mol Biol. 1998;33(2):95-149. Review.

PMID:
9598294
13.

Substrate-assisted catalysis of peptide bond formation by the ribosome.

Weinger JS, Parnell KM, Dorner S, Green R, Strobel SA.

Nat Struct Mol Biol. 2004 Nov;11(11):1101-6. Epub 2004 Oct 10.

PMID:
15475967
14.

Modulation of the rate of peptidyl transfer on the ribosome by the nature of substrates.

Wohlgemuth I, Brenner S, Beringer M, Rodnina MV.

J Biol Chem. 2008 Nov 21;283(47):32229-35. doi: 10.1074/jbc.M805316200. Epub 2008 Sep 22.

15.

An intact ribose moiety at A2602 of 23S rRNA is key to trigger peptidyl-tRNA hydrolysis during translation termination.

Amort M, Wotzel B, Bakowska-Zywicka K, Erlacher MD, Micura R, Polacek N.

Nucleic Acids Res. 2007;35(15):5130-40. Epub 2007 Jul 26.

16.

23S rRNA nucleotides in the peptidyl transferase center are essential for tryptophanase operon induction.

Yang R, Cruz-Vera LR, Yanofsky C.

J Bacteriol. 2009 Jun;191(11):3445-50. doi: 10.1128/JB.00096-09. Epub 2009 Mar 27.

17.

RNA-assisted catalysis in a protein enzyme: The 2'-hydroxyl of tRNA(Thr) A76 promotes aminoacylation by threonyl-tRNA synthetase.

Minajigi A, Francklyn CS.

Proc Natl Acad Sci U S A. 2008 Nov 18;105(46):17748-53. doi: 10.1073/pnas.0804247105. Epub 2008 Nov 7.

18.

RNA-binding site of Escherichia coli peptidyl-tRNA hydrolase.

Giorgi L, Bontems F, Fromant M, Aubard C, Blanquet S, Plateau P.

J Biol Chem. 2011 Nov 11;286(45):39585-94. doi: 10.1074/jbc.M111.281840. Epub 2011 Sep 19.

19.

The identification of the determinants of the cyclic, sequential binding of elongation factors tu and g to the ribosome.

Yu H, Chan YL, Wool IG.

J Mol Biol. 2009 Feb 27;386(3):802-13. doi: 10.1016/j.jmb.2008.12.071. Epub 2009 Jan 6.

PMID:
19154738
20.

Movement of the 3'-end of tRNA through the peptidyl transferase centre and its inhibition by antibiotics.

Kirillov S, Porse BT, Vester B, Woolley P, Garrett RA.

FEBS Lett. 1997 Apr 14;406(3):223-33. Review.

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