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21549777,22923350,18985178,12207864,10370221,15582358,19499313,23428880,17891555,36563793,15588923,12739772,20079819,16126203,15059179,16490709,17467936,19913613,12948025,12511202,31786711,8738068,18563737,30909278,14980775,19088498,24036087,19648784,17931807,24421242,36427696,15451310,15653134,8710743,19842911,10919365,16842978,17111837,15664127,22343606,17116378,752461,12554075,12576684,27436841,8932680,27452419,24928132,12115825,11522475,24452807,24910989,8274500,12713577,11496937,19446757,16679822,7918560,27634383,11977105,23752033,17628164,10468033,22950455,18675907,11231311,26623948,11337170,24210063,26554868,14684284,19747970,19034629,27845181,14680512,25871518,17497726,10567747,19900521,25684238,21723931,28395,18503424,29180256,26635061,7494819,8169777,14621961,17459682,8593480,3247319,14661929,8403091,21303690,10585230,19331847,12761803,11745777,24446970,12713576,25261711,17270406,1512463,22285584,26593153,24950143,11576771,28117757,20068385,24076520,11516511,22064944,3741786,2128017,7536240,9635505,12069170,22607120,10620117,9232537,7205031,17191091,29192445,19566304,29746912,19544367,12033375,9037093,23015080,24134638,3244625,1394710,9811155,16239611,31029804,14976382,11976015,2395798,24992320,8141611,3171212,15102090,10053189,16260121,36750147,10824136,17887175,16472099,15129992,22653409,16679821,23943545,2754277,22452335,24101411,14648648,9885297,25612540,10884938,8272414,16638680,22310464,12648016,28389713,8921326,3620451,9294814,2395806,18079075,29869312,28534835,18514497,2235880,28028209,9292283,12761819,8058633,11041256,16354007,22750544,26568168,9423153,10504437,11440082,11170040,15691034,3730275,8165175,2886623,30943494,10446422,9892470,21830855,3794393,19862629,14567647,8570535,23196771,27019078,8956339,27184268,18543296,17659842,2308897,16715385,1794659,26613974,21283983,6693781,35150813,33341746,25234173,12377978,12492545,1328599,11288105,28664316,22465394,17173944,32312082,18298945,27333372,22982163,23293910,25273029,11992685,28845697,8054208,2079653,14757507,34738431,17525512,16188726,28596104,11182209,24510708,26506429,23651342,3346820,9853412,1457459,22326252,28689988,8401404,2095573,16447176,10798622,25283951,33924434,21771099,26956857,16883560,32794598,30629452,22466556,10859534,12767706,12753768,7904627,36047148,25925122,12476874,9363373,29462632,10518670,24239832,18200056,26447196,19456935,32983826,8923329,11069633,24256135,22209999,12648231,18481307,12648221,9529549,18601987,19236844,2760822,3624900,8681419,30709044,11522474,22733612,10397613,15290853,7625858,10990197,11058808,24854835,3734472,18401425,29154084,1929859,8477512,23921112,16982163,4067326,23277290,20158460,24438785,16292655,11292537,3715891,1423776,23343160,27108784,25757641,3668285,11694019,25445977,25322561,1919050,27697619,12824032,15609006,30696548,11489316,15761931,31203277,3233954,2860219,21790981,8961154,8799483,19727117,29662033,23327987,2867145,20574601,26695532,12820144,11169537,11205736,22702370,25969419,2367329,1606648,2022882,11803132,20533434,24187844,9724563,21832865,9519155,12476008,4051559,2307274,8592659,16715366,8481982,23357252,25947391,20582492,16001716,29366318,7581252,15482478,1791533,19136050,9426365,8302760,8722604,11108549,18465954,27998691,6726629,33680052,11489556,12425479,29370122,34273783,12636167,11274806,21833791,17867814,34627876,36716111,10328563,18465951,641761,35863596,12637788,33122012,7738800,12694885,24792828,8289121,26504764,26349639,12683844,23419949,10579684,7724493,10229642,4035664,20014281,10564070,29752541,28642155,11724228,1822178,12480283,8097771,16528354,26241749,1924148,17412537,35805423,35192857,27332684,35599823,24842663,20021023,3440932,31342293,10704807,21938301,10581419,1880720,3965580,28627472,24706625,14603481,19470004,4078703,18452436,36764498,29526550,6351137,17657437,33410546,18064682,9120766,8506849,25755997,34198892,7086651,9734826,11496961,19457015,2858555,932489,33880664,21479748,27099831,19240984,1427518,11982767,3625489,1359932,752450,32887477,34071572,9282131,3781428,32739393,10469904,16724324,1904468,12677095,12476016,6752291,17267148,30531828,9734821,28320932,30166912,19832950,18423910,22382836,239176,7870679,4045219,19250475,34675286,23820866,8243497,10940818,6766317,2095570,1763712,24018675,3247284,33050611,6711723,35691525,11768462,19559791,17621956,11028952,36615399,3171936,3411463,15029434,8483831,7104207,3449063,36463821,12747572,8699337,512881,35439574,2793767,10189271,22463041,2755119,2813262,2878991,35298332,12128163,30990830,3745946,10528090,3997718,34834173,26778740,14641878,10228586,22602,8787588,24300516,8058632,12434409,18507639,15212171,1428461,11297897,6491922,7259977,22998580,32503271,34476912,6020693,11022321,6975603,6358312,15295788,3722860,36542293,13525302,7426416,22411683,34575405,21938268,19471468,9795067,23236155,25234176,24687,7965359,5957930,18494925,8860431,23577287,15093596,13575886,26554351,25234170,11982774,35056091,12935473,34942198,14938659,20692977,14172195,13096868,22468160,13972425,13740598,5655639,32010525,14042657,17282916,13101767,33223358,28955966,28145327,36055400,19469932,4130098,28150625,14842035[uid]

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Maximum transepidermal flux for similar size phenolic compounds is enhanced by solvent uptake into the skin.

Zhang Q, Li P, Roberts MS. Zhang Q, et al. J Control Release. 2011 Aug 25;154(1):50-7. doi: 10.1016/j.jconrel.2011.04.018. Epub 2011 Apr 23. J Control Release. 2011. PMID: 21549777

Effect of vehicles on the maximum transepidermal flux of similar size phenolic compounds.

Zhang Q, Li P, Liu D, Roberts MS. Zhang Q, et al. Pharm Res. 2013 Jan;30(1):32-40. doi: 10.1007/s11095-012-0846-x. Epub 2012 Aug 25. Pharm Res. 2013. PMID: 22923350

Alteration of skin hydration and its barrier function by vehicle and permeation enhancers: a study using TGA, FTIR, TEWL and drug permeation as markers.

Shah DK, Khandavilli S, Panchagnula R. Shah DK, et al. Methods Find Exp Clin Pharmacol. 2008 Sep;30(7):499-512. doi: 10.1358/mf.2008.30.7.1159653. Methods Find Exp Clin Pharmacol. 2008. PMID: 18985178 Free article.

Effect of the solvent system on the in vitro permeability of nicardipine hydrochloride through excised rat epidermis.

Krishnaiah YS, Satyanarayana V, Karthikeyan RS. Krishnaiah YS, et al. J Pharm Pharm Sci. 2002 May-Aug;5(2):123-30. J Pharm Pharm Sci. 2002. PMID: 12207864 Free article.

Effect of ethanol/propylene glycol on the in vitro percutaneous absorption of aspirin, biophysical changes and macroscopic barrier properties of the skin.

Levang AK, Zhao K, Singh J. Levang AK, et al. Int J Pharm. 1999 Apr 30;181(2):255-63. doi: 10.1016/s0378-5173(99)00055-1. Int J Pharm. 1999. PMID: 10370221

Comparative studies on the effects of water, ethanol and water/ethanol mixtures on chemical partitioning into porcine stratum corneum and silastic membrane.

Van der Merwe D, Riviere JE. Van der Merwe D, et al. Toxicol In Vitro. 2005 Feb;19(1):69-77. doi: 10.1016/j.tiv.2004.06.002. Toxicol In Vitro. 2005. PMID: 15582358 Free article.

Skin solubility determines maximum transepidermal flux for similar size molecules.

Zhang Q, Grice JE, Li P, Jepps OG, Wang GJ, Roberts MS. Zhang Q, et al. Pharm Res. 2009 Aug;26(8):1974-85. doi: 10.1007/s11095-009-9912-4. Epub 2009 Jun 5. Pharm Res. 2009. PMID: 19499313

The effects of esterified solvents on the diffusion of a model compound across human skin: an ATR-FTIR spectroscopic study.

McAuley WJ, Chavda-Sitaram S, Mader KT, Tetteh J, Lane ME, Hadgraft J. McAuley WJ, et al. Int J Pharm. 2013 Apr 15;447(1-2):1-6. doi: 10.1016/j.ijpharm.2013.02.022. Epub 2013 Feb 18. Int J Pharm. 2013. PMID: 23428880

An integrated pharmacokinetic and imaging evaluation of vehicle effects on solute human epidermal flux and, retention characteristics.

Winckle G, Anissimov YG, Cross SE, Wise G, Roberts MS. Winckle G, et al. Pharm Res. 2008 Jan;25(1):158-66. doi: 10.1007/s11095-007-9416-z. Epub 2007 Sep 22. Pharm Res. 2008. PMID: 17891555

A thermodynamic and kinetic analysis of human epidermal penetration of phenolic compounds: II. Maximum flux and solute diffusion through stratum corneum lipids.

Zhang Q, Alinaghi A, Williams DB, Roberts MS. Zhang Q, et al. Int J Pharm. 2023 Jan 25;631:122522. doi: 10.1016/j.ijpharm.2022.122522. Epub 2022 Dec 20. Int J Pharm. 2023. PMID: 36563793

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