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21540090,21961961,26060397,23291552,23562534,21458552,16814968,19434851,22414388,24785575,23523546,18556158,17075869,22435399,28872678,16516450,24566254,21520089,26951566,20417274,26742430,22885158,25009979,19235553,20887787,16297483,23093903,27951411,20803125,16109466,18765282,18579353,24311942,26292058,23318367,28223260,16846725,26187778,22300415,28830781,22989976,17712849,20102737,20334539,20540685,11604272,32112895,20367177,25195539,24103635,25445518,24388913,18509597,17184938,21601623,21486533,30395834,30217767,19339221,26863889,19429297,18608468,20307634,16647232,24840928,23323843,18339815,23911341,17566595,23830765,29926245,28236405,21679756,21706270,26548349,17034654,30655668,19471892,23194889,15953200,19100319,27654575,23046250,27645428,16469459,32376369,26637232,22643224,22579733,18585448,20420905,17097755,24283890,28923421,29053281,21811918,18178070,19501641,27034003,24669821,24549965,24012590,21733409,16114503,21545322,24937379,19596059,30027778,23058050,21549187,18644441,19681106,27593183,32331187,20210560,19929207,18325700,17630246,30889695,27620195,23291447,18582979,27810562,19491011,17847067,10677807,18164930,23131799,21056643,17328251,20818965,21547670,30196726,25906910,18242896,20604833,29345955,28131850,19616609,25366311,19747966,22172603,26333939,23614872,15778058,23089073,32914239,30738109,17241757,27639622,23983465,32084574,24184036,17582644,18930795,14965791,23780798,28534300,27845213,36577896,29192405,22246736,25005312,26850682,25679514,22624728,23334999,30297369,22591213,30851385,21802462,22376012,24495272,23916460,29154900,18288449,28590055,27022874,20602348,21884771,24560641,31482518,23876497,25159878,21344415,23266761,24448177,28271908,27543349,21945911,18057745,26786555,29988798,22885229,24679518,23946130,28536446,22010908,25991065,27040196,35598769,31189083,25080226,34618448,28740381,29689366,21832541,23528604,33840187,22612245,24471519,28400290,21816211,23946143,32946956,30003863,28421603,26264714,23062024,25385690,25564965,31125715,21439378,29496174,29985967,30300620,21889582,32649991,23054986,30889990,21925582,28591516,30761437,16715380,25347144,28493004,28223797,11251242,19571408,28811130,26790186,30661188,30577480,28859940,18602992,25604353,23837910,22251657,25308627,31557815,22821759,23927477,26567632,22553909,24833900,35631622,29928981,20874019,25725261,16410029,23999036,24447788,26561726,24971006,21988425,21374626,27301372,19255893,22076771,21619915,28234487,34959655,34907489,36099971,31786356,32387309,24333905,26508852,30252481,26852855,25601198,23651400,12779287,22283480,25455766,22982488,22829442,25965487,23212635,21840385,23396259,22960321,35017012,23436640,28088635,37039088,31659599,28441497,32835489,29095657,20600732,21479757,23947755,32631085,19481693,17978511,28042101,32634569,28732711,32104325,34031053,24093825,22077201,22877696,17366748,21905035,20945648,29319295,31893546,23624178,26998871,32476048,22118063,30827123,33963858,23240709,36934992,17495874,28257885,27063851,30425452,30983994,30952196,32659405,30552294,23954372,25889081,31416366,19450221,23033924,25448575,21896330,24076396,9821410,24402462,22876598,21302039,25766272,33033881,25404856,26503149,15929069,29680482,22414114,22172025,22750429,21371540,31743032,36870578,17950545,29578462,29542335,21185926,32606674,25960000,27113473,28967287,27106527,17053894,23651402,23351133,24992699,22503097,9661014,36746304,30136606,34119545,22296216,33823524,18036751,21722722,23107940,23944028,27955892,29555440,33560484,17048530,18763166,28823854,31301463,35188016,23668980,14698591,31955698,10866139,31685768,31026489,35037805,28937226,25724312,24187842,24879921,30266667,23009032,23872224,32314756,23524086,26970283,27543354,32678687,27880871,22349051,23934433,31260340,32275456,24882406,29695136,22803784,28121189,27346432,32240808,26971617,30579056,35124120,24979531,31986050,15720792,24799740,28123991,22752680,24859391,23997027,25099918,35362347,22643223,21315152,29468420,23659498,29079988,28554216,33222036,34673097,31491499,23624284,26852857,26149987,30525643,28359822,23085547,26856301,18406586,7583838,10699709,12485722,18803265,16961171,11282231,20822111,29753774,26886322,26213075,27717163,27733735,15830727,31013633,12884254,30209789,25138256,30033870,24631786,20099519,32178565,35738336,29944108,20238196,26423035,32052664,36850278,31525051,17089699,22736294,29214609,29448619,26323428,25748779,29969668,35552985,24245252,28847666,30851353,21753876,28315464,14980000,23879245,19629707,33357187,25715810,25724159,27019193,32101005,22705643,29986543,33558931,23615772,25482587,25276181,25659692,22192053,32978690,19733647,30931866,31576768,32422561,32006625,25444665,23618970,21986114,35893783,36987794,34799338,34950995,31904549,10699708,33468480,26559552,36410672,32592045,30631975,30606918,31900727,22968547,23583503,29096596,26288994,10397622,37042303,32263886,27014922,36015314,33925457,31969986,12480281,33631170,26721266,35054731,20662325,26323418,34066210,29510171,28062204,30505784,31605720,7448955,27213434,30662306,36541591,33475891,23965542,32261118,26609271,33498470,34834186,30103862,36297548,10441278[uid]

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Potent dried drug nanosuspensions for oral bioavailability enhancement of poorly soluble drugs with pH-dependent solubility.

Mou D, Chen H, Wan J, Xu H, Yang X. Mou D, et al. Int J Pharm. 2011 Jul 15;413(1-2):237-44. doi: 10.1016/j.ijpharm.2011.04.034. Epub 2011 Apr 21. Int J Pharm. 2011. PMID: 21540090

Flocculated amorphous itraconazole nanoparticles for enhanced in vitro supersaturation and in vivo bioavailability.

Miller MA, DiNunzio J, Matteucci ME, Ludher BS, Williams RO, Johnston KP. Miller MA, et al. Drug Dev Ind Pharm. 2012 May;38(5):557-70. doi: 10.3109/03639045.2011.616513. Epub 2011 Oct 1. Drug Dev Ind Pharm. 2012. PMID: 21961961

Itraconazole solid dispersion prepared by a supercritical fluid technique: preparation, in vitro characterization, and bioavailability in beagle dogs.

Yin X, Daintree LS, Ding S, Ledger DM, Wang B, Zhao W, Qi J, Wu W, Han J. Yin X, et al. Drug Des Devel Ther. 2015 May 28;9:2801-10. doi: 10.2147/DDDT.S81253. eCollection 2015. Drug Des Devel Ther. 2015. PMID: 26060397 Free PMC article.

Formulation and drying of miconazole and itraconazole nanosuspensions.

Cerdeira AM, Mazzotti M, Gander B. Cerdeira AM, et al. Int J Pharm. 2013 Feb 25;443(1-2):209-20. doi: 10.1016/j.ijpharm.2012.11.044. Epub 2013 Jan 4. Int J Pharm. 2013. PMID: 23291552

Increased dissolution and oral absorption of itraconazole/Soluplus extrudate compared with itraconazole nanosuspension.

Zhang K, Yu H, Luo Q, Yang S, Lin X, Zhang Y, Tian B, Tang X. Zhang K, et al. Eur J Pharm Biopharm. 2013 Nov;85(3 Pt B):1285-92. doi: 10.1016/j.ejpb.2013.03.002. Epub 2013 Apr 3. Eur J Pharm Biopharm. 2013. PMID: 23562534

Nanosuspensions of poorly soluble drugs: preparation and development by wet milling.

Liu P, Rong X, Laru J, van Veen B, Kiesvaara J, Hirvonen J, Laaksonen T, Peltonen L. Liu P, et al. Int J Pharm. 2011 Jun 15;411(1-2):215-22. doi: 10.1016/j.ijpharm.2011.03.050. Epub 2011 Mar 31. Int J Pharm. 2011. PMID: 21458552

Cryogenic liquids, nanoparticles, and microencapsulation.

Purvis T, Vaughn JM, Rogers TL, Chen X, Overhoff KA, Sinswat P, Hu J, McConville JT, Johnston KP, Williams RO 3rd. Purvis T, et al. Int J Pharm. 2006 Oct 31;324(1):43-50. doi: 10.1016/j.ijpharm.2006.04.012. Epub 2006 Apr 28. Int J Pharm. 2006. PMID: 16814968

Amorphous compositions using concentration enhancing polymers for improved bioavailability of itraconazole.

DiNunzio JC, Miller DA, Yang W, McGinity JW, Williams RO 3rd. DiNunzio JC, et al. Mol Pharm. 2008 Nov-Dec;5(6):968-80. doi: 10.1021/mp800042d. Mol Pharm. 2008. PMID: 19434851

Solid dispersions of itraconazole for inhalation with enhanced dissolution, solubility and dispersion properties.

Duret C, Wauthoz N, Sebti T, Vanderbist F, Amighi K. Duret C, et al. Int J Pharm. 2012 May 30;428(1-2):103-13. doi: 10.1016/j.ijpharm.2012.03.002. Epub 2012 Mar 10. Int J Pharm. 2012. PMID: 22414388

Spray drying of a poorly water-soluble drug nanosuspension for tablet preparation: formulation and process optimization with bioavailability evaluation.

Sun W, Ni R, Zhang X, Li LC, Mao S. Sun W, et al. Drug Dev Ind Pharm. 2015 Jun;41(6):927-33. doi: 10.3109/03639045.2014.914528. Epub 2014 May 2. Drug Dev Ind Pharm. 2015. PMID: 24785575

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