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Items: 1 to 20 of 148

1.

Transmembrane protein 198 promotes LRP6 phosphorylation and Wnt signaling activation.

Liang J, Fu Y, Cruciat CM, Jia S, Wang Y, Tong Z, Tao Q, Ingelfinger D, Boutros M, Meng A, Niehrs C, Wu W.

Mol Cell Biol. 2011 Jul;31(13):2577-90. doi: 10.1128/MCB.05103-11. Epub 2011 May 2.

2.

Casein kinase 1 gamma couples Wnt receptor activation to cytoplasmic signal transduction.

Davidson G, Wu W, Shen J, Bilic J, Fenger U, Stannek P, Glinka A, Niehrs C.

Nature. 2005 Dec 8;438(7069):867-72.

PMID:
16341016
3.

Amer1/WTX couples Wnt-induced formation of PtdIns(4,5)P2 to LRP6 phosphorylation.

Tanneberger K, Pfister AS, Brauburger K, Schneikert J, Hadjihannas MV, Kriz V, Schulte G, Bryja V, Behrens J.

EMBO J. 2011 Apr 20;30(8):1433-43. doi: 10.1038/emboj.2011.28. Epub 2011 Feb 8.

4.

The extracellular domain of Lrp5/6 inhibits noncanonical Wnt signaling in vivo.

Bryja V, Andersson ER, Schambony A, Esner M, Bryjová L, Biris KK, Hall AC, Kraft B, Cajanek L, Yamaguchi TP, Buckingham M, Arenas E.

Mol Biol Cell. 2009 Feb;20(3):924-36. doi: 10.1091/mbc.E08-07-0711. Epub 2008 Dec 3.

5.

Lypd6 enhances Wnt/β-catenin signaling by promoting Lrp6 phosphorylation in raft plasma membrane domains.

Özhan G, Sezgin E, Wehner D, Pfister AS, Kühl SJ, Kagermeier-Schenk B, Kühl M, Schwille P, Weidinger G.

Dev Cell. 2013 Aug 26;26(4):331-45. doi: 10.1016/j.devcel.2013.07.020.

6.

Role of the Rap2/TNIK kinase pathway in regulation of LRP6 stability for Wnt signaling.

Park DS, Seo JH, Hong M, Choi SC.

Biochem Biophys Res Commun. 2013 Jun 28;436(2):338-43. doi: 10.1016/j.bbrc.2013.05.104. Epub 2013 Jun 4.

PMID:
23743195
7.

LRP6 transduces a canonical Wnt signal independently of Axin degradation by inhibiting GSK3's phosphorylation of beta-catenin.

Cselenyi CS, Jernigan KK, Tahinci E, Thorne CA, Lee LA, Lee E.

Proc Natl Acad Sci U S A. 2008 Jun 10;105(23):8032-7. doi: 10.1073/pnas.0803025105. Epub 2008 May 28.

8.

PTK7 modulates Wnt signaling activity via LRP6.

Bin-Nun N, Lichtig H, Malyarova A, Levy M, Elias S, Frank D.

Development. 2014 Jan;141(2):410-21. doi: 10.1242/dev.095984. Epub 2013 Dec 18.

9.

LDL-receptor-related proteins in Wnt signal transduction.

Tamai K, Semenov M, Kato Y, Spokony R, Liu C, Katsuyama Y, Hess F, Saint-Jeannet JP, He X.

Nature. 2000 Sep 28;407(6803):530-5.

PMID:
11029007
10.

Wnt signal amplification via activity, cooperativity, and regulation of multiple intracellular PPPSP motifs in the Wnt co-receptor LRP6.

MacDonald BT, Yokota C, Tamai K, Zeng X, He X.

J Biol Chem. 2008 Jun 6;283(23):16115-23. doi: 10.1074/jbc.M800327200. Epub 2008 Mar 24.

11.

RAB8B is required for activity and caveolar endocytosis of LRP6.

Demir K, Kirsch N, Beretta CA, Erdmann G, Ingelfinger D, Moro E, Argenton F, Carl M, Niehrs C, Boutros M.

Cell Rep. 2013 Sep 26;4(6):1224-34. doi: 10.1016/j.celrep.2013.08.008. Epub 2013 Sep 12.

12.

Waif1/5T4 inhibits Wnt/β-catenin signaling and activates noncanonical Wnt pathways by modifying LRP6 subcellular localization.

Kagermeier-Schenk B, Wehner D, Ozhan-Kizil G, Yamamoto H, Li J, Kirchner K, Hoffmann C, Stern P, Kikuchi A, Schambony A, Weidinger G.

Dev Cell. 2011 Dec 13;21(6):1129-43. doi: 10.1016/j.devcel.2011.10.015. Epub 2011 Nov 17.

13.

Wnt isoform-specific interactions with coreceptor specify inhibition or potentiation of signaling by LRP6 antibodies.

Gong Y, Bourhis E, Chiu C, Stawicki S, DeAlmeida VI, Liu BY, Phamluong K, Cao TC, Carano RA, Ernst JA, Solloway M, Rubinfeld B, Hannoush RN, Wu Y, Polakis P, Costa M.

PLoS One. 2010 Sep 13;5(9):e12682. doi: 10.1371/journal.pone.0012682.

14.

Negative regulation of LRP6 function by casein kinase I epsilon phosphorylation.

Swiatek W, Kang H, Garcia BA, Shabanowitz J, Coombs GS, Hunt DF, Virshup DM.

J Biol Chem. 2006 May 5;281(18):12233-41. Epub 2006 Mar 2.

15.

Cell cycle control of wnt receptor activation.

Davidson G, Shen J, Huang YL, Su Y, Karaulanov E, Bartscherer K, Hassler C, Stannek P, Boutros M, Niehrs C.

Dev Cell. 2009 Dec;17(6):788-99. doi: 10.1016/j.devcel.2009.11.006.

16.

Direct inhibition of GSK3beta by the phosphorylated cytoplasmic domain of LRP6 in Wnt/beta-catenin signaling.

Piao S, Lee SH, Kim H, Yum S, Stamos JL, Xu Y, Lee SJ, Lee J, Oh S, Han JK, Park BJ, Weis WI, Ha NC.

PLoS One. 2008;3(12):e4046. doi: 10.1371/journal.pone.0004046. Epub 2008 Dec 24.

17.

G Protein-coupled receptor kinases phosphorylate LRP6 in the Wnt pathway.

Chen M, Philipp M, Wang J, Premont RT, Garrison TR, Caron MG, Lefkowitz RJ, Chen W.

J Biol Chem. 2009 Dec 11;284(50):35040-8. doi: 10.1074/jbc.M109.047456. Epub 2009 Oct 2.

18.

A dual-kinase mechanism for Wnt co-receptor phosphorylation and activation.

Zeng X, Tamai K, Doble B, Li S, Huang H, Habas R, Okamura H, Woodgett J, He X.

Nature. 2005 Dec 8;438(7069):873-7.

19.

Kremen is required for neural crest induction in Xenopus and promotes LRP6-mediated Wnt signaling.

Hassler C, Cruciat CM, Huang YL, Kuriyama S, Mayor R, Niehrs C.

Development. 2007 Dec;134(23):4255-63. Epub 2007 Oct 31.

20.

Wnt3a-mediated formation of phosphatidylinositol 4,5-bisphosphate regulates LRP6 phosphorylation.

Pan W, Choi SC, Wang H, Qin Y, Volpicelli-Daley L, Swan L, Lucast L, Khoo C, Zhang X, Li L, Abrams CS, Sokol SY, Wu D.

Science. 2008 Sep 5;321(5894):1350-3. doi: 10.1126/science.1160741.

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