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Items: 1 to 20 of 110

1.

Pharmacological inhibition of HDAC6 attenuates endothelial barrier dysfunction induced by thrombin.

Saito S, Lasky JA, Guo W, Nguyen H, Mai A, Danchuk S, Sullivan DE, Shan B.

Biochem Biophys Res Commun. 2011 May 20;408(4):630-4. doi: 10.1016/j.bbrc.2011.04.075. Epub 2011 Apr 21.

2.

Selective HDAC6 inhibition prevents TNF-α-induced lung endothelial cell barrier disruption and endotoxin-induced pulmonary edema.

Yu J, Ma Z, Shetty S, Ma M, Fu J.

Am J Physiol Lung Cell Mol Physiol. 2016 Jul 1;311(1):L39-47. doi: 10.1152/ajplung.00051.2016. Epub 2016 May 17.

PMID:
27190059
3.

Cigarette Smoke Disrupted Lung Endothelial Barrier Integrity and Increased Susceptibility to Acute Lung Injury via Histone Deacetylase 6.

Borgas D, Chambers E, Newton J, Ko J, Rivera S, Rounds S, Lu Q.

Am J Respir Cell Mol Biol. 2016 May;54(5):683-96. doi: 10.1165/rcmb.2015-0149OC.

4.

Inhibition of HDAC6 deacetylase activity increases its binding with microtubules and suppresses microtubule dynamic instability in MCF-7 cells.

Asthana J, Kapoor S, Mohan R, Panda D.

J Biol Chem. 2013 Aug 2;288(31):22516-26. doi: 10.1074/jbc.M113.489328. Epub 2013 Jun 24.

5.

Histone deacetylase inhibitors prevent pulmonary endothelial hyperpermeability and acute lung injury by regulating heat shock protein 90 function.

Joshi AD, Barabutis N, Birmpas C, Dimitropoulou C, Thangjam G, Cherian-Shaw M, Dennison J, Catravas JD.

Am J Physiol Lung Cell Mol Physiol. 2015 Dec 15;309(12):L1410-9. doi: 10.1152/ajplung.00180.2015. Epub 2015 Oct 23.

6.

Taxol alleviates 2-methoxyestradiol-induced endothelial permeability.

Gorshkov BA, Zemskova MA, Verin AD, Bogatcheva NV.

Vascul Pharmacol. 2012 Jan-Feb;56(1-2):56-63. doi: 10.1016/j.vph.2011.10.002. Epub 2011 Oct 30.

7.

HDAC6 is a microtubule-associated deacetylase.

Hubbert C, Guardiola A, Shao R, Kawaguchi Y, Ito A, Nixon A, Yoshida M, Wang XF, Yao TP.

Nature. 2002 May 23;417(6887):455-8.

PMID:
12024216
8.

Activation of histone deacetylase-6 induces contractile dysfunction through derailment of α-tubulin proteostasis in experimental and human atrial fibrillation.

Zhang D, Wu CT, Qi X, Meijering RA, Hoogstra-Berends F, Tadevosyan A, Cubukcuoglu Deniz G, Durdu S, Akar AR, Sibon OC, Nattel S, Henning RH, Brundel BJ.

Circulation. 2014 Jan 21;129(3):346-58. doi: 10.1161/CIRCULATIONAHA.113.005300. Epub 2013 Oct 21.

9.

Regulation of microtubule dynamics by inhibition of the tubulin deacetylase HDAC6.

Zilberman Y, Ballestrem C, Carramusa L, Mazitschek R, Khochbin S, Bershadsky A.

J Cell Sci. 2009 Oct 1;122(Pt 19):3531-41. doi: 10.1242/jcs.046813. Epub 2009 Sep 8.

11.

HDAC6 inhibition results in tau acetylation and modulates tau phosphorylation and degradation in oligodendrocytes.

Noack M, Leyk J, Richter-Landsberg C.

Glia. 2014 Apr;62(4):535-47. doi: 10.1002/glia.22624. Epub 2014 Jan 24.

PMID:
24464872
12.

Domain-selective small-molecule inhibitor of histone deacetylase 6 (HDAC6)-mediated tubulin deacetylation.

Haggarty SJ, Koeller KM, Wong JC, Grozinger CM, Schreiber SL.

Proc Natl Acad Sci U S A. 2003 Apr 15;100(8):4389-94. Epub 2003 Apr 3.

13.

SIRT2 inactivation reveals a subset of hyperacetylated perinuclear microtubules inaccessible to HDAC6.

Skoge RH, Ziegler M.

J Cell Sci. 2016 Aug 1;129(15):2972-82. doi: 10.1242/jcs.187518. Epub 2016 Jun 16.

14.

HDAC6 regulates epidermal growth factor receptor (EGFR) endocytic trafficking and degradation in renal epithelial cells.

Liu W, Fan LX, Zhou X, Sweeney WE Jr, Avner ED, Li X.

PLoS One. 2012;7(11):e49418. doi: 10.1371/journal.pone.0049418. Epub 2012 Nov 13.

15.

Clostridium difficile toxin A decreases acetylation of tubulin, leading to microtubule depolymerization through activation of histone deacetylase 6, and this mediates acute inflammation.

Nam HJ, Kang JK, Kim SK, Ahn KJ, Seok H, Park SJ, Chang JS, Pothoulakis C, Lamont JT, Kim H.

J Biol Chem. 2010 Oct 22;285(43):32888-96. doi: 10.1074/jbc.M110.162743. Epub 2010 Aug 9.

16.

Histone deacetylase 6 (HDAC6) is an independent deacetylase for alpha-tubulin.

Zhao Z, Xu H, Gong W.

Protein Pept Lett. 2010 May;17(5):555-8.

PMID:
19961433
17.

Cystathionine γ-lyase protects vascular endothelium: a role for inhibition of histone deacetylase 6.

Leucker TM, Nomura Y, Kim JH, Bhatta A, Wang V, Wecker A, Jandu S, Santhanam L, Berkowitz D, Romer L, Pandey D.

Am J Physiol Heart Circ Physiol. 2017 Apr 1;312(4):H711-H720. doi: 10.1152/ajpheart.00724.2016. Epub 2017 Feb 10.

PMID:
28188215
18.

Inhibiting histone deacetylase 6 partly protects cultured rat cortical neurons from oxygen‑glucose deprivation‑induced necroptosis.

Yuan L, Wang Z, Liu L, Jian X.

Mol Med Rep. 2015 Aug;12(2):2661-7. doi: 10.3892/mmr.2015.3779. Epub 2015 May 13.

19.

In vivo destabilization of dynamic microtubules by HDAC6-mediated deacetylation.

Matsuyama A, Shimazu T, Sumida Y, Saito A, Yoshimatsu Y, Seigneurin-Berny D, Osada H, Komatsu Y, Nishino N, Khochbin S, Horinouchi S, Yoshida M.

EMBO J. 2002 Dec 16;21(24):6820-31.

20.

Microtubule stabilization by Mdp3 is partially attributed to its modulation of HDAC6 in addition to its association with tubulin and microtubules.

Tala, Sun X, Chen J, Zhang L, Liu N, Zhou J, Li D, Liu M.

PLoS One. 2014 Mar 10;9(3):e90932. doi: 10.1371/journal.pone.0090932. eCollection 2014.

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