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Inosine augments the effects of a Nogo receptor blocker and of environmental enrichment to restore skilled forelimb use after stroke.

Zai L, Ferrari C, Dice C, Subbaiah S, Havton LA, Coppola G, Geschwind D, Irwin N, Huebner E, Strittmatter SM, Benowitz LI.

J Neurosci. 2011 Apr 20;31(16):5977-88. doi: 10.1523/JNEUROSCI.4498-10.2011.


Inosine alters gene expression and axonal projections in neurons contralateral to a cortical infarct and improves skilled use of the impaired limb.

Zai L, Ferrari C, Subbaiah S, Havton LA, Coppola G, Strittmatter S, Irwin N, Geschwind D, Benowitz LI.

J Neurosci. 2009 Jun 24;29(25):8187-97. doi: 10.1523/JNEUROSCI.0414-09.2009.


Nogo-66 receptor antagonist peptide (NEP1-40) administration promotes functional recovery and axonal growth after lateral funiculus injury in the adult rat.

Cao Y, Shumsky JS, Sabol MA, Kushner RA, Strittmatter S, Hamers FP, Lee DH, Rabacchi SA, Murray M.

Neurorehabil Neural Repair. 2008 May-Jun;22(3):262-78. Epub 2007 Nov 30.


Inosine promotes recovery of skilled motor function in a model of focal brain injury.

Smith JM, Lunga P, Story D, Harris N, Le Belle J, James MF, Pickard JD, Fawcett JW.

Brain. 2007 Apr;130(Pt 4):915-25. Epub 2007 Feb 9.


Inosine enhances axon sprouting and motor recovery after spinal cord injury.

Kim D, Zai L, Liang P, Schaffling C, Ahlborn D, Benowitz LI.

PLoS One. 2013 Dec 2;8(12):e81948. doi: 10.1371/journal.pone.0081948. eCollection 2013.


Motor recovery and axonal plasticity with short-term amphetamine after stroke.

Papadopoulos CM, Tsai SY, Guillen V, Ortega J, Kartje GL, Wolf WA.

Stroke. 2009 Jan;40(1):294-302. doi: 10.1161/STROKEAHA.108.519769. Epub 2008 Nov 26.


Delayed systemic Nogo-66 receptor antagonist promotes recovery from spinal cord injury.

Li S, Strittmatter SM.

J Neurosci. 2003 May 15;23(10):4219-27.


Delayed anti-nogo-a therapy improves function after chronic stroke in adult rats.

Tsai SY, Papadopoulos CM, Schwab ME, Kartje GL.

Stroke. 2011 Jan;42(1):186-90. doi: 10.1161/STROKEAHA.110.590083. Epub 2010 Nov 18.


Rewiring of the corticospinal tract in the adult rat after unilateral stroke and anti-Nogo-A therapy.

Lindau NT, Bänninger BJ, Gullo M, Good NA, Bachmann LC, Starkey ML, Schwab ME.

Brain. 2014 Mar;137(Pt 3):739-56. doi: 10.1093/brain/awt336. Epub 2013 Dec 18.


Back seat driving: hindlimb corticospinal neurons assume forelimb control following ischaemic stroke.

Starkey ML, Bleul C, Zörner B, Lindau NT, Mueggler T, Rudin M, Schwab ME.

Brain. 2012 Nov;135(Pt 11):3265-81. doi: 10.1093/brain/aws270.


Neural network remodeling underlying motor map reorganization induced by rehabilitative training after ischemic stroke.

Okabe N, Shiromoto T, Himi N, Lu F, Maruyama-Nakamura E, Narita K, Iwachidou N, Yagita Y, Miyamoto O.

Neuroscience. 2016 Dec 17;339:338-362. doi: 10.1016/j.neuroscience.2016.10.008. Epub 2016 Oct 8.


Rehabilitative skilled forelimb training enhances axonal remodeling in the corticospinal pathway but not the brainstem-spinal pathways after photothrombotic stroke in the primary motor cortex.

Okabe N, Himi N, Maruyama-Nakamura E, Hayashi N, Narita K, Miyamoto O.

PLoS One. 2017 Nov 2;12(11):e0187413. doi: 10.1371/journal.pone.0187413. eCollection 2017.


Activity-based therapies to promote forelimb use after a cervical spinal cord injury.

Dai H, MacArthur L, McAtee M, Hockenbury N, Tidwell JL, McHugh B, Mansfield K, Finn T, Hamers FP, Bregman BS.

J Neurotrauma. 2009 Oct;26(10):1719-32. doi: 10.1089/neu.2008-0592.


Inosine stimulates extensive axon collateral growth in the rat corticospinal tract after injury.

Benowitz LI, Goldberg DE, Madsen JR, Soni D, Irwin N.

Proc Natl Acad Sci U S A. 1999 Nov 9;96(23):13486-90.


Nogo-66 receptor antagonist peptide promotes axonal regeneration.

GrandPré T, Li S, Strittmatter SM.

Nature. 2002 May 30;417(6888):547-51.


Inosine induces axonal rewiring and improves behavioral outcome after stroke.

Chen P, Goldberg DE, Kolb B, Lanser M, Benowitz LI.

Proc Natl Acad Sci U S A. 2002 Jun 25;99(13):9031-6.


Constraint-induced movement therapy overcomes the intrinsic axonal growth-inhibitory signals in stroke rats.

Zhao S, Zhao M, Xiao T, Jolkkonen J, Zhao C.

Stroke. 2013 Jun;44(6):1698-705. doi: 10.1161/STROKEAHA.111.000361. Epub 2013 Apr 30.


dl-3-n-butylphthalide promotes neuroplasticity and motor recovery in stroke rats.

Sun Y, Cheng X, Wang H, Mu X, Liang Y, Luo Y, Qu H, Zhao C.

Behav Brain Res. 2017 Jun 30;329:67-74. doi: 10.1016/j.bbr.2017.04.039. Epub 2017 Apr 22.


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