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Items: 1 to 20 of 117

1.

SAR of 2-amino and 2,4-diamino pyrimidines with in vivo efficacy against Trypanosoma brucei.

Perales JB, Freeman J, Bacchi CJ, Bowling T, Don R, Gaukel E, Mercer L, Moore JA 3rd, Nare B, Nguyen TM, Noe RA, Randolph R, Rewerts C, Wring SA, Yarlett N, Jacobs RT.

Bioorg Med Chem Lett. 2011 May 15;21(10):2816-9. doi: 10.1016/j.bmcl.2011.03.097. Epub 2011 Apr 1.

PMID:
21507639
2.

Synthesis and antiprotozoal activity of N-alkoxy analogues of the trypanocidal lead compound 4,4'-bis(imidazolinylamino)diphenylamine with improved human blood-brain barrier permeability.

Nieto L, Mascaraque A, Miller F, Glacial F, Ríos Martínez C, Kaiser M, Brun R, Dardonville C.

J Med Chem. 2011 Jan 27;54(2):485-94. doi: 10.1021/jm101335q. Epub 2010 Dec 22.

PMID:
21175162
3.

Novel inhibitors of Leishmanial dihydrofolate reductase.

Chowdhury SF, Di Lucrezia R, Guerrero RH, Brun R, Goodman J, Ruiz-Perez LM, Pacanowska DG, Gilbert IH.

Bioorg Med Chem Lett. 2001 Apr 23;11(8):977-80.

PMID:
11327604
4.

Antitrypanosomal structure-activity-relationship study of synthetic cynaropicrin derivatives.

Usuki T, Sato M, Hara S, Yoshimoto Y, Kondo R, Zimmermann S, Kaiser M, Brun R, Hamburger M, Adams M.

Bioorg Med Chem Lett. 2014 Feb 1;24(3):794-8. doi: 10.1016/j.bmcl.2013.12.099. Epub 2014 Jan 2.

PMID:
24433861
5.

Antitrypanosomal activities and cytotoxicity of 5-nitro-2-furancarbohydrazides.

Millet R, Maes L, Landry V, Sergheraert C, Davioud-Charvet E.

Bioorg Med Chem Lett. 2002 Dec 16;12(24):3601-4.

PMID:
12443785
6.

Synthesis and testing of 5-benzyl-2,4-diaminopyrimidines as potential inhibitors of leishmanial and trypanosomal dihydrofolate reductase.

Chowdhury SF, Guerrero RH, Brun R, Ruiz-Perez LM, Pacanowska DG, Gilbert IH.

J Enzyme Inhib Med Chem. 2002 Oct;17(5):293-302.

PMID:
12683746
7.

Synthesis and biological evaluation of 1,4-benzodiazepin-2-ones with antitrypanosomal activity.

Spencer J, Rathnam RP, Harvey AL, Clements CJ, Clark RL, Barrett MP, Wong PE, Male L, Coles SJ, Mackay SP.

Bioorg Med Chem. 2011 Mar 1;19(5):1802-15. doi: 10.1016/j.bmc.2011.01.010. Epub 2011 Jan 14.

PMID:
21306904
8.

Synthesis of oxysterols and nitrogenous sterols with antileishmanial and trypanocidal activities.

Bazin MA, Loiseau PM, Bories C, Letourneux Y, Rault S, El Kihel L.

Eur J Med Chem. 2006 Oct;41(10):1109-16. Epub 2006 Sep 1.

PMID:
16949702
9.

Trypanocidal activity of dicationic compounds related to pentamidine.

Donkor IO, Assefa H, Rattendi D, Lane S, Vargas M, Goldberg B, Bacchi C.

Eur J Med Chem. 2001 Jun;36(6):531-8.

PMID:
11525843
10.

New oxapolycyclic cage amines with NMDA receptor antagonist and trypanocidal activities.

Duque MD, Camps P, Torres E, Valverde E, Sureda FX, López-Querol M, Camins A, Prathalingam SR, Kelly JM, Vázquez S.

Bioorg Med Chem. 2010 Jan 1;18(1):46-57. doi: 10.1016/j.bmc.2009.11.017. Epub 2009 Nov 14.

PMID:
19954985
11.

Synthesis and structure-activity analysis of new phosphonium salts with potent activity against African trypanosomes.

Taladriz A, Healy A, Flores Pérez EJ, Herrero García V, Ríos Martínez C, Alkhaldi AA, Eze AA, Kaiser M, de Koning HP, Chana A, Dardonville C.

J Med Chem. 2012 Mar 22;55(6):2606-22. doi: 10.1021/jm2014259. Epub 2012 Mar 6.

PMID:
22390399
12.

Trypanocidal activity of piperazine-linked bisbenzamidines and bisbenzamidoxime, an orally active prodrug.

Huang TL, Bacchi CJ, Kode NR, Zhang Q, Wang G, Yartlet N, Rattendi D, Londono I, Mazumder L, Vanden Eynde JJ, Mayence A, Donkor IO.

Int J Antimicrob Agents. 2007 Dec;30(6):555-61. Epub 2007 Oct 24.

PMID:
17920820
13.

Chalcone-benzoxaborole hybrid molecules as potent antitrypanosomal agents.

Qiao Z, Wang Q, Zhang F, Wang Z, Bowling T, Nare B, Jacobs RT, Zhang J, Ding D, Liu Y, Zhou H.

J Med Chem. 2012 Apr 12;55(7):3553-7. doi: 10.1021/jm2012408. Epub 2012 Mar 14.

PMID:
22360533
14.

2,4-Diaminopyrimidines as inhibitors of Leishmanial and Trypanosomal dihydrofolate reductase.

Pez D, Leal I, Zuccotto F, Boussard C, Brun R, Croft SL, Yardley V, Ruiz Perez LM, Gonzalez Pacanowska D, Gilbert IH.

Bioorg Med Chem. 2003 Nov 3;11(22):4693-711.

PMID:
14556785
15.

Structure-based design and synthesis of antiparasitic pyrrolopyrimidines targeting pteridine reductase 1.

Khalaf AI, Huggan JK, Suckling CJ, Gibson CL, Stewart K, Giordani F, Barrett MP, Wong PE, Barrack KL, Hunter WN.

J Med Chem. 2014 Aug 14;57(15):6479-94. doi: 10.1021/jm500483b. Epub 2014 Jul 29.

16.

Chalcone, acyl hydrazide, and related amides kill cultured Trypanosoma brucei brucei.

Troeberg L, Chen X, Flaherty TM, Morty RE, Cheng M, Hua H, Springer C, McKerrow JH, Kenyon GL, Lonsdale-Eccles JD, Coetzer TH, Cohen FE.

Mol Med. 2000 Aug;6(8):660-9.

17.

Screening of acyl hydrazide proteinase inhibitors for antiparasitic activity against Trypanosoma brucei.

Caffrey CR, Schanz M, Nkemngu NJ, Brush M, Hansell E, Cohen FE, Flaherty TM, McKerrow JH, Steverding D.

Int J Antimicrob Agents. 2002 Mar;19(3):227-31. Erratum in: Int J Antimicrob Agents. 2005 Jul;26(1):100. Nkemgu-Njinkeng, Joseph [corrected to Nkemngu, Njinkeng Joseph]. Int J Antimicrob Agents. 2005 Nov;26(5):424.

PMID:
11932146
18.

In vitro activity of Triclisia patens and some bisbenzylisoquinoline alkaloids against Leishmania donovani and Trypanosoma brucei brucei.

del Rayo Camacho M, Phillipson JD, Croft SL, Rock P, Marshall SJ, Schiff PL Jr.

Phytother Res. 2002 Aug;16(5):432-6. Erratum in: Phytother Res 2002 Sep;16(6):602.

PMID:
12203262
19.

Trypanocidal activity of a new series of arsenical compounds the spiroarsorans.

Loiseau P, Bories C, Gayral P, Wolf JG.

Farmaco Sci. 1988 Jul-Aug;43(7-8):657-63.

PMID:
3224710
20.

Synthesis and structure-activity relationships of parasiticidal thiosemicarbazone cysteine protease inhibitors against Plasmodium falciparum, Trypanosoma brucei, and Trypanosoma cruzi.

Greenbaum DC, Mackey Z, Hansell E, Doyle P, Gut J, Caffrey CR, Lehrman J, Rosenthal PJ, McKerrow JH, Chibale K.

J Med Chem. 2004 Jun 3;47(12):3212-9.

PMID:
15163200

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