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Items: 1 to 20 of 100

1.

3-Trifluoromethylquinoxaline N,N'-dioxides as anti-trypanosomatid agents. Identification of optimal anti-T. cruzi agents and mechanism of action studies.

Benitez D, Cabrera M, Hernández P, Boiani L, Lavaggi ML, Di Maio R, Yaluff G, Serna E, Torres S, Ferreira ME, Vera de Bilbao N, Torres E, Pérez-Silanes S, Solano B, Moreno E, Aldana I, López de Ceráin A, Cerecetto H, González M, Monge A.

J Med Chem. 2011 May 26;54(10):3624-36. doi: 10.1021/jm2002469. Epub 2011 May 4.

PMID:
21506600
2.

Pyrimido[1,2-a]quinoxaline 6-oxide and phenazine 5,10-dioxide derivatives and related compounds as growth inhibitors of Trypanosoma cruzi.

Lavaggi ML, Aguirre G, Boiani L, Orelli L, García B, Cerecetto H, González M.

Eur J Med Chem. 2008 Aug;43(8):1737-41. Epub 2007 Nov 4.

PMID:
18068272
3.

2H-benzimidazole 1,3-dioxide derivatives: a new family of water-soluble anti-trypanosomatid agents.

Boiani M, Boiani L, Denicola A, Torres de Ortiz S, Serna E, Vera de Bilbao N, Sanabria L, Yaluff G, Nakayama H, Rojas de Arias A, Vega C, Rolan M, Gómez-Barrio A, Cerecetto H, Gonzalez M.

J Med Chem. 2006 Jun 1;49(11):3215-24.

PMID:
16722639
4.

Improving anti-trypanosomal activity of 3-aminoquinoxaline-2-carbonitrile N1,N4-dioxide derivatives by complexation with vanadium.

Urquiola C, Vieites M, Aguirre G, Marín A, Solano B, Arrambide G, Noblía P, Lavaggi ML, Torre MH, González M, Monge A, Gambino D, Cerecetto H.

Bioorg Med Chem. 2006 Aug 15;14(16):5503-9. Epub 2006 May 18.

PMID:
16709457
5.

Naftifine-analogues as anti-Trypanosoma cruzi agents.

Gerpe A, Boiani L, Hernández P, Sortino M, Zacchino S, González M, Cerecetto H.

Eur J Med Chem. 2010 Jun;45(6):2154-64. doi: 10.1016/j.ejmech.2010.01.052. Epub 2010 Jan 28.

PMID:
20163894
6.

Quinoxaline N,N'-dioxide derivatives and related compounds as growth inhibitors of Trypanosoma cruzi. Structure-activity relationships.

Aguirre G, Cerecetto H, Di Maio R, González M, Alfaro ME, Jaso A, Zarranz B, Ortega MA, Aldana I, Monge-Vega A.

Bioorg Med Chem Lett. 2004 Jul 16;14(14):3835-9.

PMID:
15203172
7.

Trypanocidal properties, structure-activity relationship and computational studies of quinoxaline 1,4-di-N-oxide derivatives.

Estevez Y, Quiliano M, Burguete A, Cabanillas B, Zimic M, Málaga E, Verástegui M, Pérez-Silanes S, Aldana I, Monge A, Castillo D, Deharo E.

Exp Parasitol. 2011 Apr;127(4):745-51. doi: 10.1016/j.exppara.2011.01.009. Epub 2011 Jan 25.

PMID:
21272583
8.

Mode of action of nifurtimox and N-oxide-containing heterocycles against Trypanosoma cruzi: is oxidative stress involved?

Boiani M, Piacenza L, Hernández P, Boiani L, Cerecetto H, González M, Denicola A.

Biochem Pharmacol. 2010 Jun 15;79(12):1736-45. doi: 10.1016/j.bcp.2010.02.009. Epub 2010 Feb 21.

PMID:
20178775
9.

Anti-T. cruzi activities and QSAR studies of 3-arylquinoxaline-2-carbonitrile di-N-oxides.

Vicente E, Duchowicz PR, Benítez D, Castro EA, Cerecetto H, González M, Monge A.

Bioorg Med Chem Lett. 2010 Aug 15;20(16):4831-5. doi: 10.1016/j.bmcl.2010.06.101. Epub 2010 Jun 25.

PMID:
20634064
10.

Synthesis, trypanocidal activity and docking studies of novel quinoxaline-N-acylhydrazones, designed as cruzain inhibitors candidates.

Romeiro NC, Aguirre G, Hernández P, González M, Cerecetto H, Aldana I, Pérez-Silanes S, Monge A, Barreiro EJ, Lima LM.

Bioorg Med Chem. 2009 Jan 15;17(2):641-52. doi: 10.1016/j.bmc.2008.11.065. Epub 2008 Dec 3.

PMID:
19110434
11.

Synthesis and biological evaluation of new 2-arylcarbonyl-3-trifluoromethylquinoxaline 1,4-di-N-oxide derivatives and their reduced analogues.

Solano B, Junnotula V, Marín A, Villar R, Burguete A, Vicente E, Pérez-Silanes S, Aldana I, Monge A, Dutta S, Sarkar U, Gates KS.

J Med Chem. 2007 Nov 1;50(22):5485-92. Epub 2007 Oct 2.

PMID:
17910426
12.

Synthesis and biological evaluation of novel 2,3-disubstituted quinoxaline derivatives as antileishmanial and antitrypanosomal agents.

Cogo J, Kaplum V, Sangi DP, Ueda-Nakamura T, Corrêa AG, Nakamura CV.

Eur J Med Chem. 2015 Jan 27;90:107-23. doi: 10.1016/j.ejmech.2014.11.018. Epub 2014 Nov 11.

PMID:
25461316
13.

Furoxan-, alkylnitrate-derivatives and related compounds as anti-trypanosomatid agents: mechanism of action studies.

Boiani L, Aguirre G, González M, Cerecetto H, Chidichimo A, Cazzulo JJ, Bertinaria M, Guglielmo S.

Bioorg Med Chem. 2008 Sep 1;16(17):7900-7. doi: 10.1016/j.bmc.2008.07.077. Epub 2008 Jul 29.

PMID:
18706821
14.

ESR, electrochemical, molecular modeling and biological evaluation of 4-substituted and 1,4-disubstituted 7-nitroquinoxalin-2-ones as potential anti-Trypanosoma cruzi agents.

Aguilera-Venegas B, Olea-Azar C, Norambuena E, Arán VJ, Mendizábal F, Lapier M, Maya JD, Kemmerling U, López-Muñoz R.

Spectrochim Acta A Mol Biomol Spectrosc. 2011 Mar;78(3):1004-12. doi: 10.1016/j.saa.2010.12.017. Epub 2010 Dec 16.

PMID:
21239218
15.

Novel quinoxaline 1,4-di-N-oxide derivatives as new potential antichagasic agents.

Torres E, Moreno-Viguri E, Galiano S, Devarapally G, Crawford PW, Azqueta A, Arbillaga L, Varela J, Birriel E, Di Maio R, Cerecetto H, González M, Aldana I, Monge A, Pérez-Silanes S.

Eur J Med Chem. 2013 Aug;66:324-34. doi: 10.1016/j.ejmech.2013.04.065. Epub 2013 May 30.

PMID:
23811257
16.

Synthesis of new quinoxaline-2-carboxylate 1,4-dioxide derivatives as anti-Mycobacterium tuberculosis agents.

Jaso A, Zarranz B, Aldana I, Monge A.

J Med Chem. 2005 Mar 24;48(6):2019-25.

PMID:
15771444
17.

Synthesis and biological evaluation of quinoxaline di-N-oxide derivatives with in vitro trypanocidal activity.

Pérez-Silanes S, Torres E, Arbillaga L, Varela J, Cerecetto H, González M, Azqueta A, Moreno-Viguri E.

Bioorg Med Chem Lett. 2016 Feb 1;26(3):903-6. doi: 10.1016/j.bmcl.2015.12.070. Epub 2015 Dec 21.

PMID:
26750255
18.

Benzo[1,2-c]1,2,5-oxadiazole N-oxide derivatives as potential antitrypanosomal drugs. Structure-activity relationships. Part II.

Aguirre G, Cerecetto H, Di Maio R, González M, Porcal W, Seoane G, Ortega MA, Aldana I, Monge A, Denicola A.

Arch Pharm (Weinheim). 2002 Jan;335(1):15-21.

PMID:
11933675
19.

1,2,5-Oxadiazole N-oxide derivatives and related compounds as potential antitrypanosomal drugs: structure-activity relationships.

Cerecetto H, Di Maio R, González M, Risso M, Saenz P, Seoane G, Denicola A, Peluffo G, Quijano C, Olea-Azar C.

J Med Chem. 1999 Jun 3;42(11):1941-50.

PMID:
10354402
20.

Anti-trypanosomatid benzofuroxans and deoxygenated analogues: synthesis using polymer-supported triphenylphosphine, biological evaluation and mechanism of action studies.

Castro D, Boiani L, Benitez D, Hernández P, Merlino A, Gil C, Olea-Azar C, González M, Cerecetto H, Porcal W.

Eur J Med Chem. 2009 Dec;44(12):5055-65. doi: 10.1016/j.ejmech.2009.09.009. Epub 2009 Sep 18.

PMID:
19837489

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