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Items: 1 to 20 of 113

1.

Development of tricyclic hydroxy-1H-pyrrolopyridine-trione containing HIV-1 integrase inhibitors.

Zhao XZ, Maddali K, Metifiot M, Smith SJ, Vu BC, Marchand C, Hughes SH, Pommier Y, Burke TR Jr.

Bioorg Med Chem Lett. 2011 May 15;21(10):2986-90. doi: 10.1016/j.bmcl.2011.03.047. Epub 2011 Mar 21.

2.

Design and synthesis of N-methylpyrimidone derivatives as HIV-1 integrase inhibitors.

Wang Y, Rong J, Zhang B, Hu L, Wang X, Zeng C.

Bioorg Med Chem. 2015 Feb 15;23(4):735-41. doi: 10.1016/j.bmc.2014.12.059. Epub 2015 Jan 3.

PMID:
25618597
3.

Bicyclic hydroxy-1H-pyrrolopyridine-trione containing HIV-1 integrase inhibitors.

Zhao XZ, Maddali K, Metifiot M, Smith SJ, Vu BC, Marchand C, Hughes SH, Pommier Y, Burke TR Jr.

Chem Biol Drug Des. 2012 Feb;79(2):157-65. doi: 10.1111/j.1747-0285.2011.01270.x. Epub 2011 Dec 22.

PMID:
22107736
4.

Diketoacid-genre HIV-1 integrase inhibitors containing enantiomeric arylamide functionality.

Zhao XZ, Maddali K, Marchand C, Pommier Y, Burke TR Jr.

Bioorg Med Chem. 2009 Jul 15;17(14):5318-24. doi: 10.1016/j.bmc.2009.05.008. Epub 2009 May 8.

5.

Examination of halogen substituent effects on HIV-1 integrase inhibitors derived from 2,3-dihydro-6,7-dihydroxy-1H-isoindol-1-ones and 4,5-dihydroxy-1H-isoindole-1,3(2H)-diones.

Zhao XZ, Maddali K, Vu BC, Marchand C, Hughes SH, Pommier Y, Burke TR Jr.

Bioorg Med Chem Lett. 2009 May 15;19(10):2714-7. doi: 10.1016/j.bmcl.2009.03.122. Epub 2009 Mar 28.

6.

6,7-Dihydroxyisoindolin-1-one and 7,8-Dihydroxy-3,4-Dihydroisoquinolin- 1(2H)-one Based HIV-1 Integrase Inhibitors.

Zhao XZ, Metifiot M, Smith SJ, Maddali K, Marchand C, Hughes SH, Pommier Y, Burke TR Jr.

Curr Top Med Chem. 2016;16(4):435-40. Review.

PMID:
26268341
7.

Design and synthesis of novel pyrimidone analogues as HIV-1 integrase inhibitors.

Yu S, Sanchez TW, Liu Y, Yin Y, Neamati N, Zhao G.

Bioorg Med Chem Lett. 2013 Nov 15;23(22):6134-7. doi: 10.1016/j.bmcl.2013.09.018. Epub 2013 Sep 13.

PMID:
24084160
8.

Design, synthesis and biological activity of aromatic diketone derivatives as HIV-1 integrase inhibitors.

Hu L, Li Z, Wang Z, Liu G, He X, Wang X, Zeng C.

Med Chem. 2015;11(2):180-7.

PMID:
25173788
9.

6-Benzoyl-3-hydroxypyrimidine-2,4-diones as dual inhibitors of HIV reverse transcriptase and integrase.

Tang J, Maddali K, Dreis CD, Sham YY, Vince R, Pommier Y, Wang Z.

Bioorg Med Chem Lett. 2011 Apr 15;21(8):2400-2. doi: 10.1016/j.bmcl.2011.02.069. Epub 2011 Feb 18.

10.

Design and synthesis of bicyclic pyrimidinones as potent and orally bioavailable HIV-1 integrase inhibitors.

Muraglia E, Kinzel O, Gardelli C, Crescenzi B, Donghi M, Ferrara M, Nizi E, Orvieto F, Pescatore G, Laufer R, Gonzalez-Paz O, Di Marco A, Fiore F, Monteagudo E, Fonsi M, Felock PJ, Rowley M, Summa V.

J Med Chem. 2008 Feb 28;51(4):861-74. doi: 10.1021/jm701164t. Epub 2008 Jan 25.

PMID:
18217703
11.

Triketoacid inhibitors of HIV-integrase: a new chemotype useful for probing the integrase pharmacophore.

Walker MA, Johnson T, Ma Z, Banville J, Remillard R, Kim O, Zhang Y, Staab A, Wong H, Torri A, Samanta H, Lin Z, Deminie C, Terry B, Krystal M, Meanwell N.

Bioorg Med Chem Lett. 2006 Jun 1;16(11):2920-4. Epub 2006 Mar 20.

PMID:
16546383
12.

Rational design of 2-pyrrolinones as inhibitors of HIV-1 integrase.

Ma K, Wang P, Fu W, Wan X, Zhou L, Chu Y, Ye D.

Bioorg Med Chem Lett. 2011 Nov 15;21(22):6724-7. doi: 10.1016/j.bmcl.2011.09.054. Epub 2011 Sep 20.

PMID:
21996518
13.

Synthesis of polyhydroxylated aromatics having amidation of piperazine nitrogen as HIV-1 integrase inhibitor.

Yang L, Xu X, Huang Y, Zhang B, Zeng C, He H, Wang C, Hu L.

Bioorg Med Chem Lett. 2010 Sep 15;20(18):5469-71. doi: 10.1016/j.bmcl.2010.07.087. Epub 2010 Jul 25.

PMID:
20709544
14.

Development of 2-t butyl-N-methyl pyrimidones as potent inhibitors of HIV integrase.

Di Francesco ME, Pace P, Fiore F, Naimo F, Bonelli F, Rowley M, Summa V.

Bioorg Med Chem Lett. 2008 Apr 15;18(8):2709-13. doi: 10.1016/j.bmcl.2008.03.017. Epub 2008 Mar 10.

PMID:
18362069
15.

Hydrazide-containing inhibitors of HIV-1 integrase.

Zhao H, Neamati N, Sunder S, Hong H, Wang S, Milne GW, Pommier Y, Burke TR Jr.

J Med Chem. 1997 Mar 14;40(6):937-41.

PMID:
9083482
16.

Structure activity of 3-aryl-1,3-diketo-containing compounds as HIV-1 integrase inhibitors.

Pais GC, Zhang X, Marchand C, Neamati N, Cowansage K, Svarovskaia ES, Pathak VK, Tang Y, Nicklaus M, Pommier Y, Burke TR Jr.

J Med Chem. 2002 Jul 18;45(15):3184-94.

PMID:
12109903
17.

6,7-Dihydroxy-1-oxoisoindoline-4-sulfonamide-containing HIV-1 integrase inhibitors.

Zhao XZ, Maddali K, Smith SJ, Métifiot M, Johnson BC, Marchand C, Hughes SH, Pommier Y, Burke TR Jr.

Bioorg Med Chem Lett. 2012 Dec 15;22(24):7309-13. doi: 10.1016/j.bmcl.2012.10.088. Epub 2012 Oct 27.

18.

3-Hydroxy-6,7-dihydropyrimido[2,1-c][1,4]oxazin-4(9H)-ones as new HIV-1 integrase inhibitors WO2011046873 A1.

Cotelle P.

Expert Opin Ther Pat. 2011 Nov;21(11):1799-804. doi: 10.1517/13543776.2011.624272. Epub 2011 Oct 6.

PMID:
21974685
19.

Chemical modification of coumarin dimer and HIV-1 integrase inhibitory activity.

Mao PC, Mouscadet JF, Leh H, Auclair C, Hsu LY.

Chem Pharm Bull (Tokyo). 2002 Dec;50(12):1634-7.

20.

Pharmacophore modelling and atom-based 3D-QSAR studies on N-methyl pyrimidones as HIV-1 integrase inhibitors.

Reddy KK, Singh SK, Dessalew N, Tripathi SK, Selvaraj C.

J Enzyme Inhib Med Chem. 2012 Jun;27(3):339-47. doi: 10.3109/14756366.2011.590803. Epub 2011 Jun 24.

PMID:
21699459

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