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Items: 1 to 20 of 125

1.

Synthesis and evaluation of dual site inhibitors of 3-deoxy-D-arabino-heptulosonate 7-phosphate synthase.

Walker SR, Jiao W, Parker EJ.

Bioorg Med Chem Lett. 2011 Sep 1;21(17):5092-7. doi: 10.1016/j.bmcl.2011.03.071. Epub 2011 Apr 12.

PMID:
21493065
2.

Investigating the role of the hydroxyl groups of substrate erythrose 4-phosphate in the reaction catalysed by the first enzyme of the shikimate pathway.

Tran D, Pietersma AL, Schofield LR, Rost M, Jameson GB, Parker EJ.

Bioorg Med Chem Lett. 2011 Nov 15;21(22):6838-41. doi: 10.1016/j.bmcl.2011.09.017. Epub 2011 Sep 16.

PMID:
21978677
4.

Substrate deactivation of phenylalanine-sensitive 3-deoxy-D-arabino-heptulosonate 7-phosphate synthase by erythrose 4-phosphate.

Parker EJ, Bulloch EM, Jameson GB, Abell C.

Biochemistry. 2001 Dec 11;40(49):14821-8.

PMID:
11732901
5.

Synthesis and evaluation of a mechanism-based inhibitor of a 3-deoxy-D-arabino heptulosonate 7-phosphate synthase.

Walker SR, Parker EJ.

Bioorg Med Chem Lett. 2006 Jun 1;16(11):2951-4. Epub 2006 Mar 24.

PMID:
16563755
6.

Synthesis and antibacterial activity of mechanism-based inhibitors of KDO8P synthase and DAH7P synthase.

Grison C, Petek S, Finance C, Coutrot P.

Carbohydr Res. 2005 Mar 21;340(4):529-37.

PMID:
15721322
7.
8.
9.

Allosteric inhibitor specificity of Thermotoga maritima 3-deoxy-D-arabino-heptulosonate 7-phosphate synthase.

Cross PJ, Parker EJ.

FEBS Lett. 2013 Sep 17;587(18):3063-8. doi: 10.1016/j.febslet.2013.07.044. Epub 2013 Jul 31.

10.

Substrate ambiguity and crystal structure of Pyrococcus furiosus 3-deoxy-D-arabino-heptulosonate-7-phosphate synthase: an ancestral 3-deoxyald-2-ulosonate-phosphate synthase?

Schofield LR, Anderson BF, Patchett ML, Norris GE, Jameson GB, Parker EJ.

Biochemistry. 2005 Sep 13;44(36):11950-62.

PMID:
16142893
11.
12.

Allosteric inhibition of 3-deoxy-D-arabino-heptulosonate-7-phosphate synthase alters the coordination of both substrates.

Shumilin IA, Zhao C, Bauerle R, Kretsinger RH.

J Mol Biol. 2002 Jul 26;320(5):1147-56.

PMID:
12126632
13.
14.

Structural analysis of substrate-mimicking inhibitors in complex with Neisseria meningitidis 3-deoxy-d-arabino-heptulosonate 7-phosphate synthase - The importance of accommodating the active site water.

Heyes LC, Reichau S, Cross PJ, Jameson GB, Parker EJ.

Bioorg Chem. 2014 Dec;57:242-50. doi: 10.1016/j.bioorg.2014.08.003. Epub 2014 Aug 27.

PMID:
25245459
15.
17.

Linear Free Energy Relationship Analysis of Transition State Mimicry by 3-Deoxy-d-arabino-heptulosonate-7-phosphate (DAHP) Oxime, a DAHP Synthase Inhibitor and Phosphate Mimic.

Balachandran N, To F, Berti PJ.

Biochemistry. 2017 Jan 31;56(4):592-601. doi: 10.1021/acs.biochem.6b01211. Epub 2017 Jan 13.

PMID:
28045507

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