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Items: 1 to 20 of 146


Targeting Nrf2 signaling improves bacterial clearance by alveolar macrophages in patients with COPD and in a mouse model.

Harvey CJ, Thimmulappa RK, Sethi S, Kong X, Yarmus L, Brown RH, Feller-Kopman D, Wise R, Biswal S.

Sci Transl Med. 2011 Apr 13;3(78):78ra32. doi: 10.1126/scitranslmed.3002042.


Calcium restores the macrophage response to nontypeable haemophilus influenzae in chronic obstructive pulmonary disease.

Provost KA, Smith M, Arold SP, Hava DL, Sethi S.

Am J Respir Cell Mol Biol. 2015 Jun;52(6):728-37. doi: 10.1165/rcmb.2014-0172OC.


Denitrosylation of HDAC2 by targeting Nrf2 restores glucocorticosteroid sensitivity in macrophages from COPD patients.

Malhotra D, Thimmulappa RK, Mercado N, Ito K, Kombairaju P, Kumar S, Ma J, Feller-Kopman D, Wise R, Barnes P, Biswal S.

J Clin Invest. 2011 Nov;121(11):4289-302. doi: 10.1172/JCI45144. Epub 2011 Oct 17. Retraction in: J Clin Invest. 2014 Dec;124(12):5521.


Phagocytic dysfunction of human alveolar macrophages and severity of chronic obstructive pulmonary disease.

Berenson CS, Kruzel RL, Eberhardt E, Sethi S.

J Infect Dis. 2013 Dec 15;208(12):2036-45. doi: 10.1093/infdis/jit400. Epub 2013 Aug 1.


Down-regulated NF-E2-related factor 2 in pulmonary macrophages of aged smokers and patients with chronic obstructive pulmonary disease.

Suzuki M, Betsuyaku T, Ito Y, Nagai K, Nasuhara Y, Kaga K, Kondo S, Nishimura M.

Am J Respir Cell Mol Biol. 2008 Dec;39(6):673-82. doi: 10.1165/rcmb.2007-0424OC. Epub 2008 Jun 19.


Nontypeable Haemophilus influenzae clearance by alveolar macrophages is impaired by exposure to cigarette smoke.

Martí-Lliteras P, Regueiro V, Morey P, Hood DW, Saus C, Sauleda J, Agustí AG, Bengoechea JA, Garmendia J.

Infect Immun. 2009 Oct;77(10):4232-42. doi: 10.1128/IAI.00305-09. Epub 2009 Jul 20.


Elastase/LPS-exposed mice exhibit impaired innate immune responses to bacterial challenge: role of scavenger receptor A.

Ganesan S, Faris AN, Comstock AT, Sonstein J, Curtis JL, Sajjan US.

Am J Pathol. 2012 Jan;180(1):61-72. doi: 10.1016/j.ajpath.2011.09.029. Epub 2011 Nov 8.


Impaired phagocytosis of nontypeable Haemophilus influenzae by human alveolar macrophages in chronic obstructive pulmonary disease.

Berenson CS, Garlipp MA, Grove LJ, Maloney J, Sethi S.

J Infect Dis. 2006 Nov 15;194(10):1375-84. Epub 2006 Oct 16.


Immunomodulators targeting MARCO expression improve resistance to postinfluenza bacterial pneumonia.

Wu M, Gibbons JG, DeLoid GM, Bedugnis AS, Thimmulappa RK, Biswal S, Kobzik L.

Am J Physiol Lung Cell Mol Physiol. 2017 Jul 1;313(1):L138-L153. doi: 10.1152/ajplung.00075.2017. Epub 2017 Apr 13.


NRF2 targeting: a promising therapeutic strategy in chronic obstructive pulmonary disease.

Boutten A, Goven D, Artaud-Macari E, Boczkowski J, Bonay M.

Trends Mol Med. 2011 Jul;17(7):363-71. doi: 10.1016/j.molmed.2011.02.006. Epub 2011 Apr 1. Review.


Oxidized phospholipids impair pulmonary antibacterial defenses: evidence in mice exposed to cigarette smoke.

Thimmulappa RK, Gang X, Kim JH, Sussan TE, Witztum JL, Biswal S.

Biochem Biophys Res Commun. 2012 Sep 21;426(2):253-9. doi: 10.1016/j.bbrc.2012.08.076. Epub 2012 Aug 22.


Lack of Effect of Oral Sulforaphane Administration on Nrf2 Expression in COPD: A Randomized, Double-Blind, Placebo Controlled Trial.

Wise RA, Holbrook JT, Criner G, Sethi S, Rayapudi S, Sudini KR, Sugar EA, Burke A, Thimmulappa R, Singh A, Talalay P, Fahey JW, Berenson CS, Jacobs MR, Biswal S; Broccoli Sprout Extract Trial Research Group.

PLoS One. 2016 Nov 10;11(11):e0163716. doi: 10.1371/journal.pone.0163716. eCollection 2016. Erratum in: PLoS One. 2017 Mar 28;12 (3):e0175077.


Heightened endoplasmic reticulum stress in the lungs of patients with chronic obstructive pulmonary disease: the role of Nrf2-regulated proteasomal activity.

Malhotra D, Thimmulappa R, Vij N, Navas-Acien A, Sussan T, Merali S, Zhang L, Kelsen SG, Myers A, Wise R, Tuder R, Biswal S.

Am J Respir Crit Care Med. 2009 Dec 15;180(12):1196-207. doi: 10.1164/rccm.200903-0324OC. Epub 2009 Oct 1. Retraction in: Am J Respir Crit Care Med. 2016 Feb 1;193(3):344.


Potential Link between the Sphingosine-1-Phosphate (S1P) System and Defective Alveolar Macrophage Phagocytic Function in Chronic Obstructive Pulmonary Disease (COPD).

Barnawi J, Tran H, Jersmann H, Pitson S, Roscioli E, Hodge G, Meech R, Haberberger R, Hodge S.

PLoS One. 2015 Oct 20;10(10):e0122771. doi: 10.1371/journal.pone.0122771. eCollection 2015.


Decline in NRF2-regulated antioxidants in chronic obstructive pulmonary disease lungs due to loss of its positive regulator, DJ-1.

Malhotra D, Thimmulappa R, Navas-Acien A, Sandford A, Elliott M, Singh A, Chen L, Zhuang X, Hogg J, Pare P, Tuder RM, Biswal S.

Am J Respir Crit Care Med. 2008 Sep 15;178(6):592-604. doi: 10.1164/rccm.200803-380OC. Epub 2008 Jun 12. Erratum in: Am J Respir Crit Care Med. 2009 Apr 1;179(7):624. Retraction in: Am J Respir Crit Care Med. 2016 Feb 1;193(3):344.


Bone marrow mesenchymal stem cells ameliorate lung injury through anti-inflammatory and antibacterial effect in COPD mice.

Liu HM, Liu YT, Zhang J, Ma LJ.

J Huazhong Univ Sci Technolog Med Sci. 2017 Aug;37(4):496-504. doi: 10.1007/s11596-017-1763-3. Epub 2017 Aug 8.


Activating the Nrf2-mediated antioxidant response element restores barrier function in the alveolar epithelium of HIV-1 transgenic rats.

Fan X, Staitieh BS, Jensen JS, Mould KJ, Greenberg JA, Joshi PC, Koval M, Guidot DM.

Am J Physiol Lung Cell Mol Physiol. 2013 Aug 1;305(3):L267-77. doi: 10.1152/ajplung.00288.2012. Epub 2013 Jun 7.


Effects of cigarette smoke on Toll-like receptor (TLR) activation of chronic obstructive pulmonary disease (COPD) macrophages.

Metcalfe HJ, Lea S, Hughes D, Khalaf R, Abbott-Banner K, Singh D.

Clin Exp Immunol. 2014 Jun;176(3):461-72. doi: 10.1111/cei.12289.


Alpha-1 antitrypsin supplementation improves alveolar macrophages efferocytosis and phagocytosis following cigarette smoke exposure.

Serban KA, Petrusca DN, Mikosz A, Poirier C, Lockett AD, Saint L, Justice MJ, Twigg HL 3rd, Campos MA, Petrache I.

PLoS One. 2017 Apr 27;12(4):e0176073. doi: 10.1371/journal.pone.0176073. eCollection 2017.


Sulforaphane inhibits de novo synthesis of IL-8 and MCP-1 in human epithelial cells generated by cigarette smoke extract.

Starrett W, Blake DJ.

J Immunotoxicol. 2011 Jun;8(2):150-8. doi: 10.3109/1547691X.2011.558529. Epub 2011 Mar 14.


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