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Items: 1 to 20 of 84

1.

The plasma membrane redox enzyme NQO1 sustains cellular energetics and protects human neuroblastoma cells against metabolic and proteotoxic stress.

Hyun DH, Kim J, Moon C, Lim CJ, de Cabo R, Mattson MP.

Age (Dordr). 2012 Apr;34(2):359-70. doi: 10.1007/s11357-011-9245-1. Epub 2011 Apr 13.

2.

Mitochondrial function in human neuroblastoma cells is up-regulated and protected by NQO1, a plasma membrane redox enzyme.

Kim J, Kim SK, Kim HK, Mattson MP, Hyun DH.

PLoS One. 2013 Jul 11;8(7):e69030. doi: 10.1371/journal.pone.0069030. Print 2013.

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The NQO1 bioactivatable drug, β-lapachone, alters the redox state of NQO1+ pancreatic cancer cells, causing perturbation in central carbon metabolism.

Silvers MA, Deja S, Singh N, Egnatchik RA, Sudderth J, Luo X, Beg MS, Burgess SC, DeBerardinis RJ, Boothman DA, Merritt ME.

J Biol Chem. 2017 Nov 3;292(44):18203-18216. doi: 10.1074/jbc.M117.813923. Epub 2017 Sep 15.

PMID:
28916726
6.

Up-regulation of plasma membrane-associated redox activities in neuronal cells lacking functional mitochondria.

Hyun DH, Hunt ND, Emerson SS, Hernandez JO, Mattson MP, de Cabo R.

J Neurochem. 2007 Mar;100(5):1364-74. Epub 2007 Jan 22.

7.

Calorie restriction up-regulates the plasma membrane redox system in brain cells and suppresses oxidative stress during aging.

Hyun DH, Emerson SS, Jo DG, Mattson MP, de Cabo R.

Proc Natl Acad Sci U S A. 2006 Dec 26;103(52):19908-12. Epub 2006 Dec 13.

8.

Preferential utilization of NADPH as the endogenous electron donor for NAD(P)H:quinone oxidoreductase 1 (NQO1) in intact pulmonary arterial endothelial cells.

Bongard RD, Lindemer BJ, Krenz GS, Merker MP.

Free Radic Biol Med. 2009 Jan 1;46(1):25-32. doi: 10.1016/j.freeradbiomed.2008.09.007. Epub 2008 Sep 20.

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Evidence for NAD(P)H:quinone oxidoreductase 1 (NQO1)-mediated quinone-dependent redox cycling via plasma membrane electron transport: A sensitive cellular assay for NQO1.

Tan AS, Berridge MV.

Free Radic Biol Med. 2010 Feb 1;48(3):421-9. doi: 10.1016/j.freeradbiomed.2009.11.016. Epub 2009 Nov 22. Erratum in: Free Radic Biol Med. 2010 Apr 1;48(7):978.

PMID:
19932748
11.

The plasma membrane redox system is impaired by amyloid β-peptide and in the hippocampus and cerebral cortex of 3xTgAD mice.

Hyun DH, Mughal MR, Yang H, Lee JH, Ko EJ, Hunt ND, de Cabo R, Mattson MP.

Exp Neurol. 2010 Oct;225(2):423-9. doi: 10.1016/j.expneurol.2010.07.020. Epub 2010 Jul 27.

12.

Overexpression of NQO1 protects human SK-N-MC neuroblastoma cells against dopamine-induced cell death.

Zafar KS, Inayat-Hussain SH, Siegel D, Bao A, Shieh B, Ross D.

Toxicol Lett. 2006 Oct 25;166(3):261-7. Epub 2006 Aug 15.

PMID:
16978807
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14.

Pharmacological stimulation of NADH oxidation ameliorates obesity and related phenotypes in mice.

Hwang JH, Kim DW, Jo EJ, Kim YK, Jo YS, Park JH, Yoo SK, Park MK, Kwak TH, Kho YL, Han J, Choi HS, Lee SH, Kim JM, Lee I, Kyung T, Jang C, Chung J, Kweon GR, Shong M.

Diabetes. 2009 Apr;58(4):965-74. doi: 10.2337/db08-1183. Epub 2009 Jan 9.

15.

NAD(P)H:quinone oxidoreductase 1: role as a superoxide scavenger.

Siegel D, Gustafson DL, Dehn DL, Han JY, Boonchoong P, Berliner LJ, Ross D.

Mol Pharmacol. 2004 May;65(5):1238-47.

16.

Nrf2 deficiency induces oxidative stress and promotes RANKL-induced osteoclast differentiation.

Hyeon S, Lee H, Yang Y, Jeong W.

Free Radic Biol Med. 2013 Dec;65:789-99. doi: 10.1016/j.freeradbiomed.2013.08.005. Epub 2013 Aug 14.

PMID:
23954472
17.

Dicoumarol enhances gemcitabine-induced cytotoxicity in high NQO1-expressing cholangiocarcinoma cells.

Buranrat B, Prawan A, Kukongviriyapan U, Kongpetch S, Kukongviriyapan V.

World J Gastroenterol. 2010 May 21;16(19):2362-70.

19.

Cytotoxicity of RH1: NAD(P)H:quinone acceptor oxidoreductase (NQO1)-independent oxidative stress and apoptosis induction.

Tudor G, Alley M, Nelson CM, Huang R, Covell DG, Gutierrez P, Sausville EA.

Anticancer Drugs. 2005 Apr;16(4):381-91.

PMID:
15746574
20.

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