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Rap1a activation by CalDAG-GEFI and p38 MAPK is involved in E-selectin-dependent slow leukocyte rolling.

Stadtmann A, Brinkhaus L, Mueller H, Rossaint J, Bolomini-Vittori M, Bergmeier W, Van Aken H, Wagner DD, Laudanna C, Ley K, Zarbock A.

Eur J Immunol. 2011 Jul;41(7):2074-85. doi: 10.1002/eji.201041196. Epub 2011 Jun 7.


Tyrosine kinase Btk regulates E-selectin-mediated integrin activation and neutrophil recruitment by controlling phospholipase C (PLC) gamma2 and PI3Kgamma pathways.

Mueller H, Stadtmann A, Van Aken H, Hirsch E, Wang D, Ley K, Zarbock A.

Blood. 2010 Apr 15;115(15):3118-27. doi: 10.1182/blood-2009-11-254185. Epub 2010 Feb 18.


E-selectin engages PSGL-1 and CD44 through a common signaling pathway to induce integrin alphaLbeta2-mediated slow leukocyte rolling.

Yago T, Shao B, Miner JJ, Yao L, Klopocki AG, Maeda K, Coggeshall KM, McEver RP.

Blood. 2010 Jul 22;116(3):485-94. doi: 10.1182/blood-2009-12-259556. Epub 2010 Mar 18.


PSGL-1 engagement by E-selectin signals through Src kinase Fgr and ITAM adapters DAP12 and FcR gamma to induce slow leukocyte rolling.

Zarbock A, Abram CL, Hundt M, Altman A, Lowell CA, Ley K.

J Exp Med. 2008 Sep 29;205(10):2339-47. doi: 10.1084/jem.20072660. Epub 2008 Sep 15.


Integrin activation by P-Rex1 is required for selectin-mediated slow leukocyte rolling and intravascular crawling.

Herter JM, Rossaint J, Block H, Welch H, Zarbock A.

Blood. 2013 Mar 21;121(12):2301-10. doi: 10.1182/blood-2012-09-457085. Epub 2013 Jan 23.


Crucial role of SLP-76 and ADAP for neutrophil recruitment in mouse kidney ischemia-reperfusion injury.

Block H, Herter JM, Rossaint J, Stadtmann A, Kliche S, Lowell CA, Zarbock A.

J Exp Med. 2012 Feb 13;209(2):407-21. doi: 10.1084/jem.20111493. Epub 2012 Jan 30.


Acute loss of renal function attenuates slow leukocyte rolling and transmigration by interfering with intracellular signaling.

Rossaint J, Spelten O, Kässens N, Mueller H, Van Aken HK, Singbartl K, Zarbock A.

Kidney Int. 2011 Sep;80(5):493-503. doi: 10.1038/ki.2011.125. Epub 2011 May 11.


Induction of LFA-1-dependent neutrophil rolling on ICAM-1 by engagement of E-selectin.

Chesnutt BC, Smith DF, Raffler NA, Smith ML, White EJ, Ley K.

Microcirculation. 2006 Mar;13(2):99-109.


Mice lacking the signaling molecule CalDAG-GEFI represent a model for leukocyte adhesion deficiency type III.

Bergmeier W, Goerge T, Wang HW, Crittenden JR, Baldwin AC, Cifuni SM, Housman DE, Graybiel AM, Wagner DD.

J Clin Invest. 2007 Jun;117(6):1699-707. Epub 2007 May 10.


PI3-kinase γ promotes Rap1a-mediated activation of myeloid cell integrin α4β1, leading to tumor inflammation and growth.

Schmid MC, Franco I, Kang SW, Hirsch E, Quilliam LA, Varner JA.

PLoS One. 2013;8(4):e60226. doi: 10.1371/journal.pone.0060226. Epub 2013 Apr 2.


Integrin-independent role of CalDAG-GEFI in neutrophil chemotaxis.

Carbo C, Duerschmied D, Goerge T, Hattori H, Sakai J, Cifuni SM, White GC 2nd, Chrzanowska-Wodnicka M, Luo HR, Wagner DD.

J Leukoc Biol. 2010 Aug;88(2):313-9. doi: 10.1189/jlb.0110049. Epub 2010 Apr 22.


CXCR2- and E-selectin-induced neutrophil arrest during inflammation in vivo.

Smith ML, Olson TS, Ley K.

J Exp Med. 2004 Oct 4;200(7):935-9.


HS1 deficiency impairs neutrophil recruitment in vivo and activation of the small GTPases Rac1 and Rap1.

Latasiewicz J, Artz A, Jing D, Blanco MP, Currie SM, Avila MV, Schnoor M, Vestweber D.

J Leukoc Biol. 2017 May;101(5):1133-1142. doi: 10.1189/jlb.1A0416-195R. Epub 2017 Jan 25.


Rolling on E- or P-selectin induces the extended but not high-affinity conformation of LFA-1 in neutrophils.

Kuwano Y, Spelten O, Zhang H, Ley K, Zarbock A.

Blood. 2010 Jul 29;116(4):617-24. doi: 10.1182/blood-2010-01-266122. Epub 2010 May 5.


CalDAG-GEFI is at the nexus of calcium-dependent platelet activation.

Stefanini L, Roden RC, Bergmeier W.

Blood. 2009 Sep 17;114(12):2506-14. doi: 10.1182/blood-2009-04-218768. Epub 2009 Jul 23.


Novel mutations in RASGRP2, which encodes CalDAG-GEFI, abrogate Rap1 activation, causing platelet dysfunction.

Lozano ML, Cook A, Bastida JM, Paul DS, Iruin G, Cid AR, Adan-Pedroso R, Ramón González-Porras J, Hernández-Rivas JM, Fletcher SJ, Johnson B, Morgan N, Ferrer-Marin F, Vicente V, Sondek J, Watson SP, Bergmeier W, Rivera J.

Blood. 2016 Sep 1;128(9):1282-9. doi: 10.1182/blood-2015-11-683102. Epub 2016 May 27.


CalDAG-GEFI and protein kinase C represent alternative pathways leading to activation of integrin alphaIIbbeta3 in platelets.

Cifuni SM, Wagner DD, Bergmeier W.

Blood. 2008 Sep 1;112(5):1696-703. doi: 10.1182/blood-2008-02-139733. Epub 2008 Jun 10.


Reprint of Neutrophil cell surface receptors and their intracellular signal transduction pathways.

Futosi K, Fodor S, Mócsai A.

Int Immunopharmacol. 2013 Dec;17(4):1185-97. doi: 10.1016/j.intimp.2013.11.010. Epub 2013 Nov 18. Review.


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