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Items: 1 to 20 of 91

1.

Radiosensitization of human cervical cancer cells by inhibiting ribonucleotide reductase: enhanced radiation response at low-dose rates.

Kunos CA, Colussi VC, Pink J, Radivoyevitch T, Oleinick NL.

Int J Radiat Oncol Biol Phys. 2011 Jul 15;80(4):1198-204. doi: 10.1016/j.ijrobp.2011.01.034. Epub 2011 Apr 4.

2.

Ribonucleotide reductase inhibition enhances chemoradiosensitivity of human cervical cancers.

Kunos CA, Radivoyevitch T, Pink J, Chiu SM, Stefan T, Jacobberger J, Kinsella TJ.

Radiat Res. 2010 Nov;174(5):574-81. doi: 10.1667/RR2273.1. Epub 2010 Sep 10.

3.

Modulating radiation resistance by inhibiting ribonucleotide reductase in cancers with virally or mutationally silenced p53 protein.

Kunos CA, Chiu SM, Pink J, Kinsella TJ.

Radiat Res. 2009 Dec;172(6):666-76. doi: 10.1667/RR1858.1.

4.

Deoxynucleoside salvage facilitates DNA repair during ribonucleotide reductase blockade in human cervical cancers.

Kunos CA, Ferris G, Pyatka N, Pink J, Radivoyevitch T.

Radiat Res. 2011 Oct;176(4):425-33. Epub 2011 Jul 14.

5.

In vitro and in vivo radiosensitization induced by the ribonucleotide reductase inhibitor Triapine (3-aminopyridine-2-carboxaldehyde-thiosemicarbazone).

Barker CA, Burgan WE, Carter DJ, Cerna D, Gius D, Hollingshead MG, Camphausen K, Tofilon PJ.

Clin Cancer Res. 2006 May 1;12(9):2912-8.

6.

Phase I trial of pelvic radiation, weekly cisplatin, and 3-aminopyridine-2-carboxaldehyde thiosemicarbazone (3-AP, NSC #663249) for locally advanced cervical cancer.

Kunos CA, Waggoner S, von Gruenigen V, Eldermire E, Pink J, Dowlati A, Kinsella TJ.

Clin Cancer Res. 2010 Feb 15;16(4):1298-306. doi: 10.1158/1078-0432.CCR-09-2469. Epub 2010 Feb 9.

7.

Inhibitors of ribonucleotide reductase. Comparative effects of amino- and hydroxy-substituted pyridine-2-carboxaldehyde thiosemicarbazones.

Cory JG, Cory AH, Rappa G, Lorico A, Liu MC, Lin TS, Sartorelli AC.

Biochem Pharmacol. 1994 Jul 19;48(2):335-44.

PMID:
8053929
8.

Ribonucleotide reductase inhibition restores platinum-sensitivity in platinum-resistant ovarian cancer: a Gynecologic Oncology Group Study.

Kunos C, Radivoyevitch T, Abdul-Karim FW, Fanning J, Abulafia O, Bonebrake AJ, Usha L.

J Transl Med. 2012 Apr 27;10:79. doi: 10.1186/1479-5876-10-79.

10.

Hydroxyurea and trimidox enhance the radiation effect in human pancreatic adenocarcinoma cells.

Leyden D, Ahmed N, Hassan HT.

Anticancer Res. 2000 Jan-Feb;20(1A):133-8.

PMID:
10769645
12.

The synergistic interaction of gemcitabine and cytosine arabinoside with the ribonucleotide reductase inhibitor triapine is schedule dependent.

Sigmond J, Kamphuis JA, Laan AC, Hoebe EK, Bergman AM, Peters GJ.

Biochem Pharmacol. 2007 May 15;73(10):1548-57. Epub 2007 Jan 21.

PMID:
17324380
13.

Human papillomavirus E6 and E7 oncoproteins alter cell cycle progression but not radiosensitivity of carcinoma cells treated with low-dose-rate radiation.

DeWeese TL, Walsh JC, Dillehay LE, Kessis TD, Hedrick L, Cho KR, Nelson WG.

Int J Radiat Oncol Biol Phys. 1997 Jan 1;37(1):145-54.

PMID:
9054890
14.

Ribonucleotide reductase inhibition by metal complexes of Triapine (3-aminopyridine-2-carboxaldehyde thiosemicarbazone): a combined experimental and theoretical study.

Popović-Bijelić A, Kowol CR, Lind ME, Luo J, Himo F, Enyedy EA, Arion VB, Gräslund A.

J Inorg Biochem. 2011 Nov;105(11):1422-31. doi: 10.1016/j.jinorgbio.2011.07.003. Epub 2011 Jul 31.

15.

Triapine (3-aminopyridine-2-carboxaldehyde thiosemicarbazone; 3-AP): an inhibitor of ribonucleotide reductase with antineoplastic activity.

Finch RA, Liu MC, Cory AH, Cory JG, Sartorelli AC.

Adv Enzyme Regul. 1999;39:3-12. Review.

PMID:
10470363
16.

Triapine (3-aminopyridine-2-carboxaldehyde- thiosemicarbazone): A potent inhibitor of ribonucleotide reductase activity with broad spectrum antitumor activity.

Finch RA, Liu M, Grill SP, Rose WC, Loomis R, Vasquez KM, Cheng Y, Sartorelli AC.

Biochem Pharmacol. 2000 Apr 15;59(8):983-91.

PMID:
10692563
17.

Elevated ribonucleotide reductase levels associate with suppressed radiochemotherapy response in human cervical cancers.

Kunos CA, Radivoyevitch T, Kresak A, Dawson D, Jacobberger J, Yang B, Abdul-Karim FW.

Int J Gynecol Cancer. 2012 Nov;22(9):1463-9. doi: 10.1097/IGC.0b013e318270577f.

18.

Overexpression of the R2 subunit of ribonucleotide reductase in human nasopharyngeal cancer cells reduces radiosensitivity.

Kuo ML, Hwang HS, Sosnay PR, Kunugi KA, Kinsella TJ.

Cancer J. 2003 Jul-Aug;9(4):277-85.

PMID:
12967138
19.
20.

Selective radiosensitization of human cervical cancer cells and normal cells by artemisinin through the abrogation of radiation-induced G2 block.

Gong XM, Zhang Q, Torossian A, Cao JP, Fu S.

Int J Gynecol Cancer. 2012 Jun;22(5):718-24. doi: 10.1097/IGC.0b013e31824a67c9.

PMID:
22552829

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