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Δ8-Tetrahydrocannabivarin prevents hepatic ischaemia/reperfusion injury by decreasing oxidative stress and inflammatory responses through cannabinoid CB2 receptors.

Bátkai S, Mukhopadhyay P, Horváth B, Rajesh M, Gao RY, Mahadevan A, Amere M, Battista N, Lichtman AH, Gauson LA, Maccarrone M, Pertwee RG, Pacher P.

Br J Pharmacol. 2012 Apr;165(8):2450-61. doi: 10.1111/j.1476-5381.2011.01410.x.


A new cannabinoid CB2 receptor agonist HU-910 attenuates oxidative stress, inflammation and cell death associated with hepatic ischaemia/reperfusion injury.

Horváth B, Magid L, Mukhopadhyay P, Bátkai S, Rajesh M, Park O, Tanchian G, Gao RY, Goodfellow CE, Glass M, Mechoulam R, Pacher P.

Br J Pharmacol. 2012 Apr;165(8):2462-78. doi: 10.1111/j.1476-5381.2011.01381.x.


The plant cannabinoid Delta9-tetrahydrocannabivarin can decrease signs of inflammation and inflammatory pain in mice.

Bolognini D, Costa B, Maione S, Comelli F, Marini P, Di Marzo V, Parolaro D, Ross RA, Gauson LA, Cascio MG, Pertwee RG.

Br J Pharmacol. 2010 Jun;160(3):677-87. doi: 10.1111/j.1476-5381.2010.00756.x.


AM630 behaves as a protean ligand at the human cannabinoid CB2 receptor.

Bolognini D, Cascio MG, Parolaro D, Pertwee RG.

Br J Pharmacol. 2012 Apr;165(8):2561-74. doi: 10.1111/j.1476-5381.2011.01503.x.


Evidence that the plant cannabinoid Delta9-tetrahydrocannabivarin is a cannabinoid CB1 and CB2 receptor antagonist.

Thomas A, Stevenson LA, Wease KN, Price MR, Baillie G, Ross RA, Pertwee RG.

Br J Pharmacol. 2005 Dec;146(7):917-26.


The psychoactive plant cannabinoid, Delta9-tetrahydrocannabinol, is antagonized by Delta8- and Delta9-tetrahydrocannabivarin in mice in vivo.

Pertwee RG, Thomas A, Stevenson LA, Ross RA, Varvel SA, Lichtman AH, Martin BR, Razdan RK.

Br J Pharmacol. 2007 Mar;150(5):586-94. Epub 2007 Jan 22.


Cannabinoid-2 receptor agonist HU-308 protects against hepatic ischemia/reperfusion injury by attenuating oxidative stress, inflammatory response, and apoptosis.

Rajesh M, Pan H, Mukhopadhyay P, Bátkai S, Osei-Hyiaman D, Haskó G, Liaudet L, Gao B, Pacher P.

J Leukoc Biol. 2007 Dec;82(6):1382-9. Epub 2007 Jul 25.


Cannabinoids and bone: endocannabinoids modulate human osteoclast function in vitro.

Whyte LS, Ford L, Ridge SA, Cameron GA, Rogers MJ, Ross RA.

Br J Pharmacol. 2012 Apr;165(8):2584-97. doi: 10.1111/j.1476-5381.2011.01519.x.


The phytocannabinoid, Δ⁹-tetrahydrocannabivarin, can act through 5-HT₁A receptors to produce antipsychotic effects.

Cascio MG, Zamberletti E, Marini P, Parolaro D, Pertwee RG.

Br J Pharmacol. 2015 Mar;172(5):1305-18. doi: 10.1111/bph.13000.


Differential signalling in human cannabinoid CB1 receptors and their splice variants in autaptic hippocampal neurones.

Straiker A, Wager-Miller J, Hutchens J, Mackie K.

Br J Pharmacol. 2012 Apr;165(8):2660-71. doi: 10.1111/j.1476-5381.2011.01744.x.


Symptom-relieving and neuroprotective effects of the phytocannabinoid Δ⁹-THCV in animal models of Parkinson's disease.

García C, Palomo-Garo C, García-Arencibia M, Ramos J, Pertwee R, Fernández-Ruiz J.

Br J Pharmacol. 2011 Aug;163(7):1495-506. doi: 10.1111/j.1476-5381.2011.01278.x.


The antinociceptive triterpene β-amyrin inhibits 2-arachidonoylglycerol (2-AG) hydrolysis without directly targeting cannabinoid receptors.

Chicca A, Marazzi J, Gertsch J.

Br J Pharmacol. 2012 Dec;167(8):1596-608. doi: 10.1111/j.1476-5381.2012.02059.x.


Resolvin D1 protects against hepatic ischemia/reperfusion injury in rats.

Zhang T, Shu HH, Chang L, Ye F, Xu KQ, Huang WQ.

Int Immunopharmacol. 2015 Sep;28(1):322-7. doi: 10.1016/j.intimp.2015.06.017. Epub 2015 Jun 25.


Anti-inflammatory effects of cannabinoid CB(2) receptor activation in endotoxin-induced uveitis.

Toguri JT, Lehmann C, Laprairie RB, Szczesniak AM, Zhou J, Denovan-Wright EM, Kelly ME.

Br J Pharmacol. 2014 Mar;171(6):1448-61. doi: 10.1111/bph.12545.


Evidence that the plant cannabinoid cannabigerol is a highly potent alpha2-adrenoceptor agonist and moderately potent 5HT1A receptor antagonist.

Cascio MG, Gauson LA, Stevenson LA, Ross RA, Pertwee RG.

Br J Pharmacol. 2010 Jan;159(1):129-41. doi: 10.1111/j.1476-5381.2009.00515.x. Epub 2009 Dec 4.


The phytocannabinoid Delta(9)-tetrahydrocannabivarin modulates inhibitory neurotransmission in the cerebellum.

Ma YL, Weston SE, Whalley BJ, Stephens GJ.

Br J Pharmacol. 2008 May;154(1):204-15. doi: 10.1038/bjp.2008.57. Epub 2008 Mar 3.


Cannabidiol protects against hepatic ischemia/reperfusion injury by attenuating inflammatory signaling and response, oxidative/nitrative stress, and cell death.

Mukhopadhyay P, Rajesh M, Horváth B, Bátkai S, Park O, Tanchian G, Gao RY, Patel V, Wink DA, Liaudet L, Haskó G, Mechoulam R, Pacher P.

Free Radic Biol Med. 2011 May 15;50(10):1368-81. doi: 10.1016/j.freeradbiomed.2011.02.021. Epub 2011 Mar 11.


NO donor KMUP-1 improves hepatic ischemia-reperfusion and hypoxic cell injury by inhibiting oxidative stress and pro-inflammatory signaling.

Kuo KK, Wu BN, Chiu EY, Tseng CJ, Yeh JL, Liu CP, Chai CY, Chen IJ.

Int J Immunopathol Pharmacol. 2013 Jan-Mar;26(1):93-106.


Characterization of cannabinoid receptor ligands in tissues natively expressing cannabinoid CB2 receptors.

Marini P, Cascio MG, King A, Pertwee RG, Ross RA.

Br J Pharmacol. 2013 Jun;169(4):887-99. doi: 10.1111/bph.12191.


Δ(9) -Tetrahydrocannabinol and N-arachidonyl glycine are full agonists at GPR18 receptors and induce migration in human endometrial HEC-1B cells.

McHugh D, Page J, Dunn E, Bradshaw HB.

Br J Pharmacol. 2012 Apr;165(8):2414-24. doi: 10.1111/j.1476-5381.2011.01497.x.

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