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Increased survival following tumorigenesis in Ts65Dn mice that model Down syndrome.

Yang A, Reeves RH.

Cancer Res. 2011 May 15;71(10):3573-81. doi: 10.1158/0008-5472.CAN-10-4489. Epub 2011 Apr 5.


Trisomy represses Apc(Min)-mediated tumours in mouse models of Down's syndrome.

Sussan TE, Yang A, Li F, Ostrowski MC, Reeves RH.

Nature. 2008 Jan 3;451(7174):73-5. doi: 10.1038/nature06446.


Tumour angiogenesis is reduced in the Tc1 mouse model of Down's syndrome.

Reynolds LE, Watson AR, Baker M, Jones TA, D'Amico G, Robinson SD, Joffre C, Garrido-Urbani S, Rodriguez-Manzaneque JC, Martino-Echarri E, Aurrand-Lions M, Sheer D, Dagna-Bricarelli F, Nizetic D, McCabe CJ, Turnell AS, Kermorgant S, Imhof BA, Adams R, Fisher EM, Tybulewicz VL, Hart IR, Hodivala-Dilke KM.

Nature. 2010 Jun 10;465(7299):813-7. doi: 10.1038/nature09106. Erratum in: Nature. 2010 Jul 15;466(7304):398.


The pattern of congenital heart defects arising from reduced Tbx5 expression is altered in a Down syndrome mouse model.

Polk RC, Gergics P, Steimle JD, Li H, Moskowitz IP, Camper SA, Reeves RH.

BMC Dev Biol. 2015 Jul 25;15:30. doi: 10.1186/s12861-015-0080-y.


Complex contributions of Ets2 to craniofacial and thymus phenotypes of trisomic "Down syndrome" mice.

Hill CA, Sussan TE, Reeves RH, Richtsmeier JT.

Am J Med Genet A. 2009 Oct;149A(10):2158-65. doi: 10.1002/ajmg.a.33012.


Down's syndrome: paradox of a tumour repressor.

Threadgill DW.

Nature. 2008 Jan 3;451(7174):21-2. doi: 10.1038/451021a. No abstract available.


A single extra copy of Dscr1 improves survival of mice developing spontaneous lung tumors through suppression of tumor angiogenesis.

Shin J, Lee JC, Baek KH.

Cancer Lett. 2014 Jan 1;342(1):70-81. doi: 10.1016/j.canlet.2013.08.047. Epub 2013 Sep 16.


Highly penetrant myeloproliferative disease in the Ts65Dn mouse model of Down syndrome.

Kirsammer G, Jilani S, Liu H, Davis E, Gurbuxani S, Le Beau MM, Crispino JD.

Blood. 2008 Jan 15;111(2):767-75. Epub 2007 Sep 27.


Overlapping trisomies for human chromosome 21 orthologs produce similar effects on skull and brain morphology of Dp(16)1Yey and Ts65Dn mice.

Starbuck JM, Dutka T, Ratliff TS, Reeves RH, Richtsmeier JT.

Am J Med Genet A. 2014 Aug;164A(8):1981-90. doi: 10.1002/ajmg.a.36594. Epub 2014 May 1.


Penetrance of Congenital Heart Disease in a Mouse Model of Down Syndrome Depends on a Trisomic Potentiator of a Disomic Modifier.

Li H, Edie S, Klinedinst D, Jeong JS, Blackshaw S, Maslen CL, Reeves RH.

Genetics. 2016 Jun;203(2):763-70. doi: 10.1534/genetics.116.188045. Epub 2016 Mar 30.


Genetically mediated Nf1 loss in mice promotes diverse radiation-induced tumors modeling second malignant neoplasms.

Choi G, Huang B, Pinarbasi E, Braunstein SE, Horvai AE, Kogan S, Bhatia S, Faddegon B, Nakamura JL.

Cancer Res. 2012 Dec 15;72(24):6425-34. doi: 10.1158/0008-5472.CAN-12-1728. Epub 2012 Oct 15.


Abnormal mineralization of the Ts65Dn Down syndrome mouse appendicular skeleton begins during embryonic development in a Dyrk1a-independent manner.

Blazek JD, Malik AM, Tischbein M, Arbones ML, Moore CS, Roper RJ.

Mech Dev. 2015 May;136:133-42. doi: 10.1016/j.mod.2014.12.004. Epub 2014 Dec 30.


Molecular characterization of the translocation breakpoints in the Down syndrome mouse model Ts65Dn.

Reinholdt LG, Ding Y, Gilbert GJ, Czechanski A, Solzak JP, Roper RJ, Johnson MT, Donahue LR, Lutz C, Davisson MT.

Mamm Genome. 2011 Dec;22(11-12):685-91. doi: 10.1007/s00335-011-9357-z. Epub 2011 Sep 28. Erratum in: Mamm Genome. 2011 Dec;22(11-12):692. Gilbert, Griffith T [corrected to Gilbert, Griffith J].


Increased male reproductive success in Ts65Dn "Down syndrome" mice.

Moore CS, Hawkins C, Franca A, Lawler A, Devenney B, Das I, Reeves RH.

Mamm Genome. 2010 Dec;21(11-12):543-9. doi: 10.1007/s00335-010-9300-8. Epub 2010 Nov 26.


Widespread cerebellar transcriptome changes in Ts65Dn Down syndrome mouse model after lifelong running.

Walus M, Kida E, Rabe A, Albertini G, Golabek AA.

Behav Brain Res. 2016 Jan 1;296:35-46. doi: 10.1016/j.bbr.2015.08.015. Epub 2015 Aug 21.


Trisomy of the Dscr1 gene suppresses early progression of pancreatic intraepithelial neoplasia driven by oncogenic Kras.

Lee JC, Shin J, Baek KH.

Biochem Biophys Res Commun. 2013 Oct 11;440(1):50-5. doi: 10.1016/j.bbrc.2013.09.033. Epub 2013 Sep 13.


Ets transcription factors and targets in osteogenesis.

Raouf A, Seth A.

Oncogene. 2000 Dec 18;19(55):6455-63. Review.


Differential effects of trisomy on brain shape and volume in related aneuploid mouse models.

Aldridge K, Reeves RH, Olson LE, Richtsmeier JT.

Am J Med Genet A. 2007 May 15;143A(10):1060-70.


Embryonic and not maternal trisomy causes developmental attenuation in the Ts65Dn mouse model for Down syndrome.

Blazek JD, Billingsley CN, Newbauer A, Roper RJ.

Dev Dyn. 2010 Jun;239(6):1645-53. doi: 10.1002/dvdy.22295.


Transcript level alterations reflect gene dosage effects across multiple tissues in a mouse model of down syndrome.

Kahlem P, Sultan M, Herwig R, Steinfath M, Balzereit D, Eppens B, Saran NG, Pletcher MT, South ST, Stetten G, Lehrach H, Reeves RH, Yaspo ML.

Genome Res. 2004 Jul;14(7):1258-67.

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