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Items: 1 to 20 of 105

1.

Regulation of endothelial barrier function by TGF-β type I receptor ALK5: potential role of contractile mechanisms and heat shock protein 90.

Antonov AS, Antonova GN, Fujii M, ten Dijke P, Handa V, Catravas JD, Verin AD.

J Cell Physiol. 2012 Feb;227(2):759-71. doi: 10.1002/jcp.22785.

2.

Heat shock protein 90 inhibitors protect and restore pulmonary endothelial barrier function.

Antonov A, Snead C, Gorshkov B, Antonova GN, Verin AD, Catravas JD.

Am J Respir Cell Mol Biol. 2008 Nov;39(5):551-9. doi: 10.1165/rcmb.2007-0324OC. Epub 2008 May 12.

3.

ALK5 and Smad4 are involved in TGF-beta1-induced pulmonary endothelial permeability.

Birukova AA, Adyshev D, Gorshkov B, Birukov KG, Verin AD.

FEBS Lett. 2005 Jul 18;579(18):4031-7.

4.

Activin Receptor-Like Kinase Receptors ALK5 and ALK1 Are Both Required for TGFβ-Induced Chondrogenic Differentiation of Human Bone Marrow-Derived Mesenchymal Stem Cells.

de Kroon LM, Narcisi R, Blaney Davidson EN, Cleary MA, van Beuningen HM, Koevoet WJ, van Osch GJ, van der Kraan PM.

PLoS One. 2015 Dec 31;10(12):e0146124. doi: 10.1371/journal.pone.0146124. eCollection 2015.

5.

ALK1 opposes ALK5/Smad3 signaling and expression of extracellular matrix components in human chondrocytes.

Finnson KW, Parker WL, ten Dijke P, Thorikay M, Philip A.

J Bone Miner Res. 2008 Jun;23(6):896-906. doi: 10.1359/jbmr.080209.

6.

ALK5 and ALK1 play antagonistic roles in transforming growth factor β-induced podosome formation in aortic endothelial cells.

Curado F, Spuul P, Egaña I, Rottiers P, Daubon T, Veillat V, Duhamel P, Leclercq A, Gontier E, Génot E.

Mol Cell Biol. 2014 Dec;34(24):4389-403. doi: 10.1128/MCB.01026-14. Epub 2014 Sep 29.

7.

Expression of vascular endothelial growth factor is coordinately regulated by the activin-like kinase receptors 1 and 5 in endothelial cells.

Shao ES, Lin L, Yao Y, Boström KI.

Blood. 2009 Sep 3;114(10):2197-206. doi: 10.1182/blood-2009-01-199166. Epub 2009 Jun 8.

8.

Balancing the activation state of the endothelium via two distinct TGF-beta type I receptors.

Goumans MJ, Valdimarsdottir G, Itoh S, Rosendahl A, Sideras P, ten Dijke P.

EMBO J. 2002 Apr 2;21(7):1743-53.

9.

Involvement of microtubules and Rho pathway in TGF-beta1-induced lung vascular barrier dysfunction.

Birukova AA, Birukov KG, Adyshev D, Usatyuk P, Natarajan V, Garcia JG, Verin AD.

J Cell Physiol. 2005 Sep;204(3):934-47.

PMID:
15828024
10.

Transforming growth factor-beta1 causes pulmonary microvascular endothelial cell apoptosis via ALK5.

Lu Q, Patel B, Harrington EO, Rounds S.

Am J Physiol Lung Cell Mol Physiol. 2009 May;296(5):L825-38. doi: 10.1152/ajplung.90307.2008. Epub 2009 Mar 6.

11.

Distinct regulation of gene expression in human endothelial cells by TGF-beta and its receptors.

Wu X, Ma J, Han JD, Wang N, Chen YG.

Microvasc Res. 2006 Jan;71(1):12-9. Epub 2006 Jan 5.

PMID:
16405919
12.

Activin receptor-like kinase 1 modulates transforming growth factor-beta 1 signaling in the regulation of angiogenesis.

Oh SP, Seki T, Goss KA, Imamura T, Yi Y, Donahoe PK, Li L, Miyazono K, ten Dijke P, Kim S, Li E.

Proc Natl Acad Sci U S A. 2000 Mar 14;97(6):2626-31.

13.

ALK5- and TGFBR2-independent role of ALK1 in the pathogenesis of hereditary hemorrhagic telangiectasia type 2.

Park SO, Lee YJ, Seki T, Hong KH, Fliess N, Jiang Z, Park A, Wu X, Kaartinen V, Roman BL, Oh SP.

Blood. 2008 Jan 15;111(2):633-42. Epub 2007 Oct 2.

14.

Increase in ALK1/ALK5 ratio as a cause for elevated MMP-13 expression in osteoarthritis in humans and mice.

Blaney Davidson EN, Remst DF, Vitters EL, van Beuningen HM, Blom AB, Goumans MJ, van den Berg WB, van der Kraan PM.

J Immunol. 2009 Jun 15;182(12):7937-45. doi: 10.4049/jimmunol.0803991. Erratum in: J Immunol. 2010 Aug 15;185(4):2629.

15.

Endothelial fibrosis induced by suppressed STAT3 expression mediated by signaling involving the TGF-β1/ALK5/Smad pathway.

Becerra A, Rojas M, Vallejos A, Villegas V, Pérez L, Cabello-Verrugio C, Simon F.

Lab Invest. 2017 Sep;97(9):1033-1046. doi: 10.1038/labinvest.2017.61. Epub 2017 Jul 24.

PMID:
28737766
16.

Transforming growth factor-beta1 protects against pulmonary artery endothelial cell apoptosis via ALK5.

Lu Q.

Am J Physiol Lung Cell Mol Physiol. 2008 Jul;295(1):L123-33. doi: 10.1152/ajplung.00402.2007. Epub 2008 May 2.

18.

Smad2/Smad3 in endothelium is indispensable for vascular stability via S1PR1 and N-cadherin expressions.

Itoh F, Itoh S, Adachi T, Ichikawa K, Matsumura Y, Takagi T, Festing M, Watanabe T, Weinstein M, Karlsson S, Kato M.

Blood. 2012 May 31;119(22):5320-8. doi: 10.1182/blood-2011-12-395772. Epub 2012 Apr 12.

19.

Activin receptor-like kinase (ALK)1 is an antagonistic mediator of lateral TGFbeta/ALK5 signaling.

Goumans MJ, Valdimarsdottir G, Itoh S, Lebrin F, Larsson J, Mummery C, Karlsson S, ten Dijke P.

Mol Cell. 2003 Oct;12(4):817-28.

20.

GATA6 promotes angiogenic function and survival in endothelial cells by suppression of autocrine transforming growth factor beta/activin receptor-like kinase 5 signaling.

Froese N, Kattih B, Breitbart A, Grund A, Geffers R, Molkentin JD, Kispert A, Wollert KC, Drexler H, Heineke J.

J Biol Chem. 2011 Feb 18;286(7):5680-90. doi: 10.1074/jbc.M110.176925. Epub 2010 Dec 2.

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