Similar articles for PMID: 21460794

Year	Number of Results
2003	1
2004	1
2005	2
2009	3
2010	7
2011	7
2012	13
2013	16
2014	11
2015	13
2016	17
2017	8
2018	12
2019	8
2020	8
2021	6
2022	8
2023	2
2024	0

1

The oncometabolite 2-hydroxyglutarate inhibits histone lysine demethylases.

Chowdhury R, Yeoh KK, Tian YM, Hillringhaus L, Bagg EA, Rose NR, Leung IK, Li XS, Woon EC, Yang M, McDonough MA, King ON, Clifton IJ, Klose RJ, Claridge TD, Ratcliffe PJ, Schofield CJ, Kawamura A. Chowdhury R, et al. EMBO Rep. 2011 May;12(5):463-9. doi: 10.1038/embor.2011.43. Epub 2011 Apr 1. EMBO Rep. 2011. PMID: 21460794 Free PMC article.

2

Oncometabolite 2-hydroxyglutarate is a competitive inhibitor of α-ketoglutarate-dependent dioxygenases.

Xu W, Yang H, Liu Y, Yang Y, Wang P, Kim SH, Ito S, Yang C, Wang P, Xiao MT, Liu LX, Jiang WQ, Liu J, Zhang JY, Wang B, Frye S, Zhang Y, Xu YH, Lei QY, Guan KL, Zhao SM, Xiong Y. Xu W, et al. Cancer Cell. 2011 Jan 18;19(1):17-30. doi: 10.1016/j.ccr.2010.12.014. Cancer Cell. 2011. PMID: 21251613 Free PMC article.

3

What a difference a hydroxyl makes: mutant IDH, (R)-2-hydroxyglutarate, and cancer.

Losman JA, Kaelin WG Jr. Losman JA, et al. Genes Dev. 2013 Apr 15;27(8):836-52. doi: 10.1101/gad.217406.113. Genes Dev. 2013. PMID: 23630074 Free PMC article. Review.

4

(R)-2-hydroxyglutarate is sufficient to promote leukemogenesis and its effects are reversible.

Losman JA, Looper RE, Koivunen P, Lee S, Schneider RK, McMahon C, Cowley GS, Root DE, Ebert BL, Kaelin WG Jr. Losman JA, et al. Science. 2013 Mar 29;339(6127):1621-5. doi: 10.1126/science.1231677. Epub 2013 Feb 7. Science. 2013. PMID: 23393090 Free PMC article.

5

Studies on the Interaction of the Histone Demethylase KDM5B with Tricarboxylic Acid Cycle Intermediates.

Tarhonskaya H, Nowak RP, Johansson C, Szykowska A, Tumber A, Hancock RL, Lang P, Flashman E, Oppermann U, Schofield CJ, Kawamura A. Tarhonskaya H, et al. J Mol Biol. 2017 Sep 15;429(19):2895-2906. doi: 10.1016/j.jmb.2017.08.007. Epub 2017 Aug 18. J Mol Biol. 2017. PMID: 28827149 Free PMC article.

6

IDH mutation impairs histone demethylation and results in a block to cell differentiation.

Lu C, Ward PS, Kapoor GS, Rohle D, Turcan S, Abdel-Wahab O, Edwards CR, Khanin R, Figueroa ME, Melnick A, Wellen KE, O'Rourke DM, Berger SL, Chan TA, Levine RL, Mellinghoff IK, Thompson CB. Lu C, et al. Nature. 2012 Feb 15;483(7390):474-8. doi: 10.1038/nature10860. Nature. 2012. PMID: 22343901 Free PMC article.

7

The cancer driver genes IDH1/2, JARID1C/ KDM5C, and UTX/ KDM6A: crosstalk between histone demethylation and hypoxic reprogramming in cancer metabolism.

Chang S, Yim S, Park H. Chang S, et al. Exp Mol Med. 2019 Jun 20;51(6):1-17. doi: 10.1038/s12276-019-0230-6. Exp Mol Med. 2019. PMID: 31221981 Free PMC article. Review.

8

[(R)-2-hydroxyglutarate or (R)-2HG is an oncometabolite].

Larsen CJ. Larsen CJ. Bull Cancer. 2013 Jul-Aug;100(7-8):655. Bull Cancer. 2013. PMID: 24063024 French. No abstract available.

9

Transformation by the (R)-enantiomer of 2-hydroxyglutarate linked to EGLN activation.

Koivunen P, Lee S, Duncan CG, Lopez G, Lu G, Ramkissoon S, Losman JA, Joensuu P, Bergmann U, Gross S, Travins J, Weiss S, Looper R, Ligon KL, Verhaak RG, Yan H, Kaelin WG Jr. Koivunen P, et al. Nature. 2012 Feb 15;483(7390):484-8. doi: 10.1038/nature10898. Nature. 2012. PMID: 22343896 Free PMC article.

10

Isocitrate dehydrogenase mutation as a therapeutic target in gliomas.

Han CH, Batchelor TT. Han CH, et al. Chin Clin Oncol. 2017 Jun;6(3):33. doi: 10.21037/cco.2017.06.11. Chin Clin Oncol. 2017. PMID: 28705010 Free article.

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