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Items: 1 to 20 of 94


Distinct roles of Cdc42 in thymopoiesis and effector and memory T cell differentiation.

Guo F, Zhang S, Tripathi P, Mattner J, Phelan J, Sproles A, Mo J, Wills-Karp M, Grimes HL, Hildeman D, Zheng Y.

PLoS One. 2011 Mar 24;6(3):e18002. doi: 10.1371/journal.pone.0018002.


Rho GTPase Cdc42 is essential for human T-cell development.

Smits K, Iannucci V, Stove V, Van Hauwe P, Naessens E, Meuwissen PJ, Ariën KK, Bentahir M, Plum J, Verhasselt B.

Haematologica. 2010 Mar;95(3):367-75. doi: 10.3324/haematol.2009.006890.


SLAT regulates CD8+ T cell clonal expansion in a Cdc42- and NFAT1-dependent manner.

Feau S, Schoenberger SP, Altman A, Bécart S.

J Immunol. 2013 Jan 1;190(1):174-83. doi: 10.4049/jimmunol.1201685.


RasGRP1 transmits prodifferentiation TCR signaling that is crucial for CD4 T cell development.

Priatel JJ, Chen X, Dhanji S, Abraham N, Teh HS.

J Immunol. 2006 Aug 1;177(3):1470-80.


Overexpression of the Runx3 transcription factor increases the proportion of mature thymocytes of the CD8 single-positive lineage.

Kohu K, Sato T, Ohno S, Hayashi K, Uchino R, Abe N, Nakazato M, Yoshida N, Kikuchi T, Iwakura Y, Inoue Y, Watanabe T, Habu S, Satake M.

J Immunol. 2005 Mar 1;174(5):2627-36.


A role for p120 RasGAP in thymocyte positive selection and survival of naive T cells.

Lapinski PE, Qiao Y, Chang CH, King PD.

J Immunol. 2011 Jul 1;187(1):151-63. doi: 10.4049/jimmunol.1100178.


Expression of activated CDC42 induces T cell apoptosis in thymus and peripheral lymph organs via different pathways.

Na S, Li B, Grewal IS, Enslen H, Davis RJ, Hanke JH, Flavell RA.

Oncogene. 1999 Dec 23;18(56):7966-74.


The transient expression of C-C chemokine receptor 8 in thymus identifies a thymocyte subset committed to become CD4+ single-positive T cells.

Kremer L, Carramolino L, Goya I, Zaballos A, Gutiérrez J, Moreno-Ortiz M del C, Martínez-A C, Márquez G.

J Immunol. 2001 Jan 1;166(1):218-25.


The molecular signature underlying the thymic migration and maturation of TCRαβ+ CD4+ CD8 thymocytes.

Teng F, Zhou Y, Jin R, Chen Y, Pei X, Liu Y, Dong J, Wang W, Pang X, Qian X, Chen WF, Zhang Y, Ge Q.

PLoS One. 2011;6(10):e25567. doi: 10.1371/journal.pone.0025567.


Zfat-deficient CD4⁺ CD8⁺ double-positive thymocytes are susceptible to apoptosis with deregulated activation of p38 and JNK.

Ishikura S, Ogawa M, Doi K, Matsuzaki H, Iwaihara Y, Tanaka Y, Tsunoda T, Hideshima H, Okamura T, Shirasawa S.

J Cell Biochem. 2015 Jan;116(1):149-57. doi: 10.1002/jcb.24954.


CD155 is involved in negative selection and is required to retain terminally maturing CD8 T cells in thymus.

Qiu Q, Ravens I, Seth S, Rathinasamy A, Maier MK, Davalos-Misslitz A, Forster R, Bernhardt G.

J Immunol. 2010 Feb 15;184(4):1681-9. doi: 10.4049/jimmunol.0900062.


MEK activity regulates negative selection of immature CD4+CD8+ thymocytes.

Bommhardt U, Scheuring Y, Bickel C, Zamoyska R, Hünig T.

J Immunol. 2000 Mar 1;164(5):2326-37.


Characterization of ζ-associated protein, 70 kd (ZAP70)-deficient human lymphocytes.

Roifman CM, Dadi H, Somech R, Nahum A, Sharfe N.

J Allergy Clin Immunol. 2010 Dec;126(6):1226-33.e1. doi: 10.1016/j.jaci.2010.07.029.


4-1BB ligand induces cell division, sustains survival, and enhances effector function of CD4 and CD8 T cells with similar efficacy.

Cannons JL, Lau P, Ghumman B, DeBenedette MA, Yagita H, Okumura K, Watts TH.

J Immunol. 2001 Aug 1;167(3):1313-24.


The quantity of TCR signal determines positive selection and lineage commitment of T cells.

Watanabe N, Arase H, Onodera M, Ohashi PS, Saito T.

J Immunol. 2000 Dec 1;165(11):6252-61.

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