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Items: 1 to 20 of 197

1.

Potent inhibitors of a shikimate pathway enzyme from Mycobacterium tuberculosis: combining mechanism- and modeling-based design.

Reichau S, Jiao W, Walker SR, Hutton RD, Baker EN, Parker EJ.

J Biol Chem. 2011 May 6;286(18):16197-207. doi: 10.1074/jbc.M110.211649.

2.
4.

Substrate ambiguity and crystal structure of Pyrococcus furiosus 3-deoxy-D-arabino-heptulosonate-7-phosphate synthase: an ancestral 3-deoxyald-2-ulosonate-phosphate synthase?

Schofield LR, Anderson BF, Patchett ML, Norris GE, Jameson GB, Parker EJ.

Biochemistry. 2005 Sep 13;44(36):11950-62.

PMID:
16142893
5.

Allosteric inhibitor specificity of Thermotoga maritima 3-deoxy-D-arabino-heptulosonate 7-phosphate synthase.

Cross PJ, Parker EJ.

FEBS Lett. 2013 Sep 17;587(18):3063-8. doi: 10.1016/j.febslet.2013.07.044.

6.

Synergistic allostery, a sophisticated regulatory network for the control of aromatic amino acid biosynthesis in Mycobacterium tuberculosis.

Webby CJ, Jiao W, Hutton RD, Blackmore NJ, Baker HM, Baker EN, Jameson GB, Parker EJ.

J Biol Chem. 2010 Oct 1;285(40):30567-76. doi: 10.1074/jbc.M110.111856.

7.

Design and structural analysis of aromatic inhibitors of type II dehydroquinase from Mycobacterium tuberculosis.

Howard NI, Dias MV, Peyrot F, Chen L, Schmidt MF, Blundell TL, Abell C.

ChemMedChem. 2015 Jan;10(1):116-33. doi: 10.1002/cmdc.201402298.

PMID:
25234229
8.

Investigating the role of the hydroxyl groups of substrate erythrose 4-phosphate in the reaction catalysed by the first enzyme of the shikimate pathway.

Tran D, Pietersma AL, Schofield LR, Rost M, Jameson GB, Parker EJ.

Bioorg Med Chem Lett. 2011 Nov 15;21(22):6838-41. doi: 10.1016/j.bmcl.2011.09.017.

PMID:
21978677
9.

Structure of shikimate kinase from Mycobacterium tuberculosis reveals the binding of shikimic acid.

Pereira JH, de Oliveira JS, Canduri F, Dias MV, Palma MS, Basso LA, Santos DS, de Azevedo WF Jr.

Acta Crystallogr D Biol Crystallogr. 2004 Dec;60(Pt 12 Pt 2):2310-9.

PMID:
15583379
10.

Interaction of shikimic acid with shikimate kinase.

Pereira JH, de Oliveira JS, Canduri F, Dias MV, Palma MS, Basso LA, de Azevedo WF Jr, Santos DS.

Biochem Biophys Res Commun. 2004 Dec 3;325(1):10-7. Retraction in: Biochem Biophys Res Commun. 2005 Sep 2;334(3):967.

PMID:
15522194
11.

Dynamic cross-talk among remote binding sites: the molecular basis for unusual synergistic allostery.

Jiao W, Hutton RD, Cross PJ, Jameson GB, Parker EJ.

J Mol Biol. 2012 Jan 27;415(4):716-26. doi: 10.1016/j.jmb.2011.11.037.

PMID:
22154807
12.
13.

Expression, purification and properties of shikimate dehydrogenase from Mycobacterium tuberculosis.

Zhang X, Zhang S, Hao F, Lai X, Yu H, Huang Y, Wang H.

J Biochem Mol Biol. 2005 Sep 30;38(5):624-31.

PMID:
16202245
14.

Effects of the magnesium and chloride ions and shikimate on the structure of shikimate kinase from Mycobacterium tuberculosis.

Dias MV, Faím LM, Vasconcelos IB, de Oliveira JS, Basso LA, Santos DS, de Azevedo WF Jr.

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2007 Jan 1;63(Pt 1):1-6.

15.

A novel inhibitor of indole-3-glycerol phosphate synthase with activity against multidrug-resistant Mycobacterium tuberculosis.

Shen H, Wang F, Zhang Y, Huang Q, Xu S, Hu H, Yue J, Wang H.

FEBS J. 2009 Jan;276(1):144-54. doi: 10.1111/j.1742-4658.2008.06763.x.

16.

Inhibition of 3-deoxy-D-arabino-heptulosonate 7-phosphate synthase from Mycobacterium tuberculosis: in silico screening and in vitro validation.

Nirmal CR, Rao R, Hopper W.

Eur J Med Chem. 2015 Nov 13;105:182-93. doi: 10.1016/j.ejmech.2015.10.014.

PMID:
26491981
17.

Functional shikimate dehydrogenase from Mycobacterium tuberculosis H37Rv: purification and characterization.

Fonseca IO, Magalhães ML, Oliveira JS, Silva RG, Mendes MA, Palma MS, Santos DS, Basso LA.

Protein Expr Purif. 2006 Apr;46(2):429-37.

PMID:
16298142
18.

Three sites and you are out: ternary synergistic allostery controls aromatic amino acid biosynthesis in Mycobacterium tuberculosis.

Blackmore NJ, Reichau S, Jiao W, Hutton RD, Baker EN, Jameson GB, Parker EJ.

J Mol Biol. 2013 May 13;425(9):1582-92. doi: 10.1016/j.jmb.2012.12.019.

PMID:
23274137
19.

Structural investigation of inhibitor designs targeting 3-dehydroquinate dehydratase from the shikimate pathway of Mycobacterium tuberculosis.

Dias MV, Snee WC, Bromfield KM, Payne RJ, Palaninathan SK, Ciulli A, Howard NI, Abell C, Sacchettini JC, Blundell TL.

Biochem J. 2011 Jun 15;436(3):729-39. doi: 10.1042/BJ20110002.

PMID:
21410435
20.

Mechanism of phosphoryl transfer catalyzed by shikimate kinase from Mycobacterium tuberculosis.

Hartmann MD, Bourenkov GP, Oberschall A, Strizhov N, Bartunik HD.

J Mol Biol. 2006 Dec 1;364(3):411-23.

PMID:
17020768
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