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Hepatic steatosis, inflammation, and ER stress in mice maintained long term on a very low-carbohydrate ketogenic diet.

Garbow JR, Doherty JM, Schugar RC, Travers S, Weber ML, Wentz AE, Ezenwajiaku N, Cotter DG, Brunt EM, Crawford PA.

Am J Physiol Gastrointest Liver Physiol. 2011 Jun;300(6):G956-67. doi: 10.1152/ajpgi.00539.2010. Epub 2011 Mar 31.


Role of choline deficiency in the Fatty liver phenotype of mice fed a low protein, very low carbohydrate ketogenic diet.

Schugar RC, Huang X, Moll AR, Brunt EM, Crawford PA.

PLoS One. 2013 Aug 29;8(8):e74806. doi: 10.1371/journal.pone.0074806. eCollection 2013.


Low-carbohydrate ketogenic diets, glucose homeostasis, and nonalcoholic fatty liver disease.

Schugar RC, Crawford PA.

Curr Opin Clin Nutr Metab Care. 2012 Jul;15(4):374-80. doi: 10.1097/MCO.0b013e3283547157. Review.


Long-term ketogenic diet causes glucose intolerance and reduced β- and α-cell mass but no weight loss in mice.

Ellenbroek JH, van Dijck L, Töns HA, Rabelink TJ, Carlotti F, Ballieux BE, de Koning EJ.

Am J Physiol Endocrinol Metab. 2014 Mar 1;306(5):E552-8. doi: 10.1152/ajpendo.00453.2013. Epub 2014 Jan 7.


Dietary capsaicin reduces obesity-induced insulin resistance and hepatic steatosis in obese mice fed a high-fat diet.

Kang JH, Goto T, Han IS, Kawada T, Kim YM, Yu R.

Obesity (Silver Spring). 2010 Apr;18(4):780-7. doi: 10.1038/oby.2009.301. Epub 2009 Oct 1.


Dissociation of hepatic insulin resistance from susceptibility of nonalcoholic fatty liver disease induced by a high-fat and high-carbohydrate diet in mice.

Asai A, Chou PM, Bu HF, Wang X, Rao MS, Jiang A, DiDonato CJ, Tan XD.

Am J Physiol Gastrointest Liver Physiol. 2014 Mar;306(6):G496-504. doi: 10.1152/ajpgi.00291.2013. Epub 2014 Jan 16.


Garcinia Cambogia attenuates diet-induced adiposity but exacerbates hepatic collagen accumulation and inflammation.

Kim YJ, Choi MS, Park YB, Kim SR, Lee MK, Jung UJ.

World J Gastroenterol. 2013 Aug 7;19(29):4689-701. doi: 10.3748/wjg.v19.i29.4689.


Prevention and reversal of hepatic steatosis with a high-protein diet in mice.

Garcia-Caraballo SC, Comhair TM, Verheyen F, Gaemers I, Schaap FG, Houten SM, Hakvoort TB, Dejong CH, Lamers WH, Koehler SE.

Biochim Biophys Acta. 2013 May;1832(5):685-95. doi: 10.1016/j.bbadis.2013.02.003. Epub 2013 Feb 11.


High-protein diets prevent steatosis and induce hepatic accumulation of monomethyl branched-chain fatty acids.

Garcia Caraballo SC, Comhair TM, Houten SM, Dejong CH, Lamers WH, Koehler SE.

J Nutr Biochem. 2014 Dec;25(12):1263-74. doi: 10.1016/j.jnutbio.2014.07.005. Epub 2014 Sep 16.


Differing endoplasmic reticulum stress response to excess lipogenesis versus lipid oversupply in relation to hepatic steatosis and insulin resistance.

Ren LP, Chan SM, Zeng XY, Laybutt DR, Iseli TJ, Sun RQ, Kraegen EW, Cooney GJ, Turner N, Ye JM.

PLoS One. 2012;7(2):e30816. doi: 10.1371/journal.pone.0030816. Epub 2012 Feb 15.


Effects of increased dietary cholesterol with carbohydrate restriction on hepatic lipid metabolism in Guinea pigs.

deOgburn R, Leite JO, Ratliff J, Volek JS, McGrane MM, Fernandez ML.

Comp Med. 2012 Apr;62(2):109-15.


Endoplasmic reticulum-tethered transcription factor cAMP responsive element-binding protein, hepatocyte specific, regulates hepatic lipogenesis, fatty acid oxidation, and lipolysis upon metabolic stress in mice.

Zhang C, Wang G, Zheng Z, Maddipati KR, Zhang X, Dyson G, Williams P, Duncan SA, Kaufman RJ, Zhang K.

Hepatology. 2012 Apr;55(4):1070-82. doi: 10.1002/hep.24783. Epub 2012 Feb 9.


Methionine restriction prevents the progression of hepatic steatosis in leptin-deficient obese mice.

Malloy VL, Perrone CE, Mattocks DA, Ables GP, Caliendo NS, Orentreich DS, Orentreich N.

Metabolism. 2013 Nov;62(11):1651-61. doi: 10.1016/j.metabol.2013.06.012. Epub 2013 Aug 5.


Long-term ketogenic diet contributes to glycemic control but promotes lipid accumulation and hepatic steatosis in type 2 diabetic mice.

Zhang X, Qin J, Zhao Y, Shi J, Lan R, Gan Y, Ren H, Zhu B, Qian M, Du B.

Nutr Res. 2016 Apr;36(4):349-358. doi: 10.1016/j.nutres.2015.12.002. Epub 2015 Dec 7.


Dietary fat intake promotes the development of hepatic steatosis independently from excess caloric consumption in a murine model.

de Meijer VE, Le HD, Meisel JA, Akhavan Sharif MR, Pan A, Nosé V, Puder M.

Metabolism. 2010 Aug;59(8):1092-105. doi: 10.1016/j.metabol.2009.11.006. Epub 2010 Jan 8.


A very low carbohydrate ketogenic diet improves glucose tolerance in ob/ob mice independently of weight loss.

Badman MK, Kennedy AR, Adams AC, Pissios P, Maratos-Flier E.

Am J Physiol Endocrinol Metab. 2009 Nov;297(5):E1197-204. doi: 10.1152/ajpendo.00357.2009. Epub 2009 Sep 8.


Protection against Western diet-induced obesity and hepatic steatosis in liver fatty acid-binding protein knockout mice.

Newberry EP, Xie Y, Kennedy SM, Luo J, Davidson NO.

Hepatology. 2006 Nov;44(5):1191-205.


Hepatic extracellular signal-regulated kinase 2 suppresses endoplasmic reticulum stress and protects from oxidative stress and endothelial dysfunction.

Kujiraoka T, Satoh Y, Ayaori M, Shiraishi Y, Arai-Nakaya Y, Hakuno D, Yada H, Kuwada N, Endo S, Isoda K, Adachi T.

J Am Heart Assoc. 2013 Aug 16;2(4):e000361. doi: 10.1161/JAHA.113.000361.


Effects of exercise and low-fat diet on adipose tissue inflammation and metabolic complications in obese mice.

Vieira VJ, Valentine RJ, Wilund KR, Antao N, Baynard T, Woods JA.

Am J Physiol Endocrinol Metab. 2009 May;296(5):E1164-71. doi: 10.1152/ajpendo.00054.2009. Epub 2009 Mar 10.


Dietary effects on liver tumor burden in mice treated with the hepatocellular carcinogen diethylnitrosamine.

Healy ME, Chow JD, Byrne FL, Breen DS, Leitinger N, Li C, Lackner C, Caldwell SH, Hoehn KL.

J Hepatol. 2015 Mar;62(3):599-606. doi: 10.1016/j.jhep.2014.10.024. Epub 2014 Oct 23.

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