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Salen Mn complexes mitigate radiation injury in normal tissues.

Rosenthal RA, Fish B, Hill RP, Huffman KD, Lazarova Z, Mahmood J, Medhora M, Molthen R, Moulder JE, Sonis ST, Tofilon PJ, Doctrow SR.

Anticancer Agents Med Chem. 2011 May 1;11(4):359-72. Review.


Novel synthetic SOD/catalase mimetics can mitigate capillary endothelial cell apoptosis caused by ionizing radiation.

Vorotnikova E, Rosenthal RA, Tries M, Doctrow SR, Braunhut SJ.

Radiat Res. 2010 Jun;173(6):748-59. doi: 10.1667/RR1948.1.


A synthetic superoxide dismutase/catalase mimetic EUK-207 mitigates radiation dermatitis and promotes wound healing in irradiated rat skin.

Doctrow SR, Lopez A, Schock AM, Duncan NE, Jourdan MM, Olasz EB, Moulder JE, Fish BL, M├Ąder M, Lazar J, Lazarova Z.

J Invest Dermatol. 2013 Apr;133(4):1088-96. doi: 10.1038/jid.2012.410. Epub 2012 Nov 29. Erratum in: J Invest Dermatol. 2013 Jun;133(6):1691.


Mitigating effect of EUK-207 on radiation-induced cognitive impairments.

Raber J, Davis MJ, Pfankuch T, Rosenthal R, Doctrow SR, Moulder JE.

Behav Brain Res. 2017 Mar 1;320:457-463. doi: 10.1016/j.bbr.2016.10.038. Epub 2016 Oct 24.


Mitigation of radiation-induced lung injury with EUK-207 and genistein: effects in adolescent rats.

Mahmood J, Jelveh S, Zaidi A, Doctrow SR, Hill RP.

Radiat Res. 2013 Feb;179(2):125-34. doi: 10.1667/RR2954.1. Epub 2012 Dec 13.


Superoxide dismutase mimetics with catalase activity reduce the organ injury in hemorrhagic shock.

Izumi M, McDonald MC, Sharpe MA, Chatterjee PK, Thiemermann C.

Shock. 2002 Sep;18(3):230-5.


EUK-8, a superoxide dismutase and catalase mimetic, reduces cardiac oxidative stress and ameliorates pressure overload-induced heart failure in the harlequin mouse mutant.

van Empel VP, Bertrand AT, van Oort RJ, van der Nagel R, Engelen M, van Rijen HV, Doevendans PA, Crijns HJ, Ackerman SL, Sluiter W, De Windt LJ.

J Am Coll Cardiol. 2006 Aug 15;48(4):824-32. Epub 2006 Jul 25.


A superoxide dismutase mimetic with catalase activity (EUK-8) reduces the organ injury in endotoxic shock.

McDonald MC, d'Emmanuele di Villa Bianca R, Wayman NS, Pinto A, Sharpe MA, Cuzzocrea S, Chatterjee PK, Thiemermann C.

Eur J Pharmacol. 2003 Apr 11;466(1-2):181-9.


Role of oxidant stress in the adult respiratory distress syndrome: evaluation of a novel antioxidant strategy in a porcine model of endotoxin-induced acute lung injury.

Gonzalez PK, Zhuang J, Doctrow SR, Malfroy B, Benson PF, Menconi MJ, Fink MP.

Shock. 1996;6 Suppl 1:S23-6. Review.


Antioxidant, EUK-8, prevents murine dilated cardiomyopathy.

Kawakami S, Matsuda A, Sunagawa T, Noda Y, Kaneko T, Tahara S, Hiraumi Y, Adachi S, Matsui H, Ando K, Fujita T, Maruyama N, Shirasawa T, Shimizu T.

Circ J. 2009 Nov;73(11):2125-34. Epub 2009 Sep 14.


Salen-manganese complexes as catalytic scavengers of hydrogen peroxide and cytoprotective agents: structure-activity relationship studies.

Doctrow SR, Huffman K, Marcus CB, Tocco G, Malfroy E, Adinolfi CA, Kruk H, Baker K, Lazarowych N, Mascarenhas J, Malfroy B.

J Med Chem. 2002 Sep 26;45(20):4549-58.


EUK-8, a synthetic superoxide dismutase and catalase mimetic, ameliorates acute lung injury in endotoxemic swine.

Gonzalez PK, Zhuang J, Doctrow SR, Malfroy B, Benson PF, Menconi MJ, Fink MP.

J Pharmacol Exp Ther. 1995 Nov;275(2):798-806.


Orally available Mn porphyrins with superoxide dismutase and catalase activities.

Rosenthal RA, Huffman KD, Fisette LW, Damphousse CA, Callaway WB, Malfroy B, Doctrow SR.

J Biol Inorg Chem. 2009 Aug;14(6):979-91. doi: 10.1007/s00775-009-0550-4. Epub 2009 Jun 6.


EUK-134 reduces renal dysfunction and injury caused by oxidative and nitrosative stress of the kidney.

Chatterjee PK, Patel NS, Kvale EO, Brown PA, Stewart KN, Mota-Filipe H, Sharpe MA, Di Paola R, Cuzzocrea S, Thiemermann C.

Am J Nephrol. 2004 Mar-Apr;24(2):165-77. Epub 2004 Jan 29.


Antioxidant mimetics modulate oxidative stress and cellular signaling in airway epithelial cells infected with respiratory syncytial virus.

Hosakote YM, Komaravelli N, Mautemps N, Liu T, Garofalo RP, Casola A.

Am J Physiol Lung Cell Mol Physiol. 2012 Dec 1;303(11):L991-1000. doi: 10.1152/ajplung.00192.2012. Epub 2012 Sep 28.


alpha-Lipoic acid and glutathione protect against the prooxidant activity of SOD/catalase mimetic manganese salen derivatives.

Fucassi F, Lowe JE, Pavey KD, Shah S, Faragher RG, Green MH, Paul F, O'Hare D, Cragg PJ.

J Inorg Biochem. 2007 Feb;101(2):225-32. Epub 2006 Oct 5.


The manganese-salen compound EUK-134 and N-acetyl cysteine rescue from zinc- and paraquat-induced toxicity in rat polymorphonuclear leukocytes.

Kumar A, Shukla S, Chauhan AK, Singh D, Pandey HP, Singh C.

Chem Biol Interact. 2015 Apr 25;231:18-26. doi: 10.1016/j.cbi.2015.02.012. Epub 2015 Feb 24.


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