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Items: 1 to 20 of 99

1.

Structurally sophisticated octahedral metal complexes as highly selective protein kinase inhibitors.

Feng L, Geisselbrecht Y, Blanck S, Wilbuer A, Atilla-Gokcumen GE, Filippakopoulos P, Kräling K, Celik MA, Harms K, Maksimoska J, Marmorstein R, Frenking G, Knapp S, Essen LO, Meggers E.

J Am Chem Soc. 2011 Apr 20;133(15):5976-86. doi: 10.1021/ja1112996. Epub 2011 Mar 29.

2.

Targeting large kinase active site with rigid, bulky octahedral ruthenium complexes.

Maksimoska J, Feng L, Harms K, Yi C, Kissil J, Marmorstein R, Meggers E.

J Am Chem Soc. 2008 Nov 26;130(47):15764-5. doi: 10.1021/ja805555a.

3.

Octahedral rhodium(III) complexes as kinase inhibitors: Control of the relative stereochemistry with acyclic tridentate ligands.

Mollin S, Riedel R, Harms K, Meggers E.

J Inorg Biochem. 2015 Jul;148:11-21. doi: 10.1016/j.jinorgbio.2015.01.005. Epub 2015 Jan 22.

PMID:
25660487
4.
5.

Bioactive cyclometalated phthalimides: design, synthesis and kinase inhibition.

Blanck S, Geisselbrecht Y, Kräling K, Middel S, Mietke T, Harms K, Essen LO, Meggers E.

Dalton Trans. 2012 Aug 21;41(31):9337-48. doi: 10.1039/c2dt30940h. Epub 2012 Jun 26.

6.

Group 9 organometallic compounds for therapeutic and bioanalytical applications.

Ma DL, Chan DS, Leung CH.

Acc Chem Res. 2014 Dec 16;47(12):3614-31. doi: 10.1021/ar500310z. Epub 2014 Nov 4.

PMID:
25369127
7.

Iridium complex with antiangiogenic properties.

Wilbuer A, Vlecken DH, Schmitz DJ, Kräling K, Harms K, Bagowski CP, Meggers E.

Angew Chem Int Ed Engl. 2010 May 17;49(22):3839-42. doi: 10.1002/anie.201000682. No abstract available.

PMID:
20437440
8.

Asymmetric catalysis mediated by the ligand sphere of octahedral chiral-at-metal complexes.

Gong L, Chen LA, Meggers E.

Angew Chem Int Ed Engl. 2014 Oct 6;53(41):10868-74. doi: 10.1002/anie.201404305. Epub 2014 Aug 25. Review.

PMID:
25156957
9.

Novel C,N-Cyclometalated Benzimidazole Ruthenium(II) and Iridium(III) Complexes as Antitumor and Antiangiogenic Agents: A Structure-Activity Relationship Study.

Yellol J, Pérez SA, Buceta A, Yellol G, Donaire A, Szumlas P, Bednarski PJ, Makhloufi G, Janiak C, Espinosa A, Ruiz J.

J Med Chem. 2015 Sep 24;58(18):7310-27. doi: 10.1021/acs.jmedchem.5b01194. Epub 2015 Sep 4.

PMID:
26313136
10.

Rhodium(III) and iridium(III) complexes with 1,2-naphthoquinone-1-oximate as a bidentate ligand: synthesis, structure, and biological activity.

Wirth S, Rohbogner CJ, Cieslak M, Kazmierczak-Baranska J, Donevski S, Nawrot B, Lorenz IP.

J Biol Inorg Chem. 2010 Mar;15(3):429-40. doi: 10.1007/s00775-009-0615-4. Epub 2009 Dec 19.

PMID:
20091072
11.

Metal complexes as protein kinase inhibitors.

Kunick C, Ott I.

Angew Chem Int Ed Engl. 2010 Jul 19;49(31):5226-7. doi: 10.1002/anie.201002062. No abstract available.

PMID:
20589820
12.

Scaffold mining of kinase hinge binders in crystal structure database.

Xing L, Rai B, Lunney EA.

J Comput Aided Mol Des. 2014 Jan;28(1):13-23. doi: 10.1007/s10822-013-9700-4. Epub 2013 Dec 29.

PMID:
24375079
13.

Chiral-auxiliary-mediated asymmetric synthesis of ruthenium polypyridyl complexes.

Gong L, Wenzel M, Meggers E.

Acc Chem Res. 2013 Nov 19;46(11):2635-44. doi: 10.1021/ar400083u. Epub 2013 Jun 3.

PMID:
23730834
14.

Identification of chemically diverse Chk1 inhibitors by receptor-based virtual screening.

Foloppe N, Fisher LM, Howes R, Potter A, Robertson AG, Surgenor AE.

Bioorg Med Chem. 2006 Jul 15;14(14):4792-802. Epub 2006 Mar 29.

PMID:
16574416
15.

Correlation between the Stereochemistry and Bioactivity in Octahedral Rhodium Prolinato Complexes.

Rajaratnam R, Martin EK, Dörr M, Harms K, Casini A, Meggers E.

Inorg Chem. 2015 Aug 17;54(16):8111-20. doi: 10.1021/acs.inorgchem.5b01349. Epub 2015 Aug 7.

PMID:
26251218
16.

Development of novel molecular probes of the Rio1 atypical protein kinase.

Mielecki M, Krawiec K, Kiburu I, Grzelak K, Zagórski W, Kierdaszuk B, Kowa K, Fokt I, Szymanski S, Swierk P, Szeja W, Priebe W, Lesyng B, LaRonde-LeBlanc N.

Biochim Biophys Acta. 2013 Jul;1834(7):1292-301. doi: 10.1016/j.bbapap.2013.03.012. Epub 2013 Mar 20.

PMID:
23523885
17.

Addressing the Glycine-Rich Loop of Protein Kinases by a Multi-Facetted Interaction Network: Inhibition of PKA and a PKB Mimic.

Lauber BS, Hardegger LA, Asraful AK, Lund BA, Dumele O, Harder M, Kuhn B, Engh RA, Diederich F.

Chemistry. 2016 Jan 4;22(1):211-21. doi: 10.1002/chem.201503552. Epub 2015 Nov 18.

PMID:
26578105
18.

Kinase hinge binding scaffolds and their hydrogen bond patterns.

Xing L, Klug-Mcleod J, Rai B, Lunney EA.

Bioorg Med Chem. 2015 Oct 1;23(19):6520-7. doi: 10.1016/j.bmc.2015.08.006. Epub 2015 Aug 29.

PMID:
26358279
19.

Crystal structures and DFT calculations of new chlorido-dimethylsulfoxide-M(III) (M = Ir, Ru, Rh) complexes with the N-pyrazolyl pyrimidine donor ligand: kinetic vs. thermodynamic isomers.

Cánaves MM, Cabra MI, Bauzá A, Cañellas P, Sánchez K, Orvay F, García-Raso A, Fiol JJ, Terrón A, Barceló-Oliver M, Ballester P, Mata I, Molins E, Hussain F, Frontera A.

Dalton Trans. 2014 May 7;43(17):6353-64. doi: 10.1039/c3dt52700j.

PMID:
24599509
20.

3-(Indol-2-yl)indazoles as Chek1 kinase inhibitors: Optimization of potency and selectivity via substitution at C6.

Fraley ME, Steen JT, Brnardic EJ, Arrington KL, Spencer KL, Hanney BA, Kim Y, Hartman GD, Stirdivant SM, Drakas BA, Rickert K, Walsh ES, Hamilton K, Buser CA, Hardwick J, Tao W, Beck SC, Mao X, Lobell RB, Sepp-Lorenzino L, Yan Y, Ikuta M, Munshi SK, Kuo LC, Kreatsoulas C.

Bioorg Med Chem Lett. 2006 Dec 1;16(23):6049-53. Epub 2006 Sep 15.

PMID:
16978863

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