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Items: 1 to 20 of 293

1.

The cellular prion protein mediates neurotoxic signalling of β-sheet-rich conformers independent of prion replication.

Resenberger UK, Harmeier A, Woerner AC, Goodman JL, Müller V, Krishnan R, Vabulas RM, Kretzschmar HA, Lindquist S, Hartl FU, Multhaup G, Winklhofer KF, Tatzelt J.

EMBO J. 2011 May 18;30(10):2057-70. doi: 10.1038/emboj.2011.86. Epub 2011 Mar 25.

2.

Cellular prion protein mediates toxic signaling of amyloid beta.

Resenberger UK, Winklhofer KF, Tatzelt J.

Neurodegener Dis. 2012;10(1-4):298-300. doi: 10.1159/000332596. Epub 2011 Dec 9.

PMID:
22156337
3.

High molecular mass assemblies of amyloid-β oligomers bind prion protein in patients with Alzheimer's disease.

Dohler F, Sepulveda-Falla D, Krasemann S, Altmeppen H, Schlüter H, Hildebrand D, Zerr I, Matschke J, Glatzel M.

Brain. 2014 Mar;137(Pt 3):873-86. doi: 10.1093/brain/awt375. Epub 2014 Feb 10.

PMID:
24519981
4.

Decoding the function of the N-terminal tail of the cellular prion protein to inspire novel therapeutic avenues for neurodegenerative diseases.

Iraci N, Stincardini C, Barreca ML, Biasini E.

Virus Res. 2015 Sep 2;207:62-8. doi: 10.1016/j.virusres.2014.10.015. Epub 2014 Oct 23. Review.

PMID:
25456402
5.

Exosomal cellular prion protein drives fibrillization of amyloid beta and counteracts amyloid beta-mediated neurotoxicity.

Falker C, Hartmann A, Guett I, Dohler F, Altmeppen H, Betzel C, Schubert R, Thurm D, Wegwitz F, Joshi P, Verderio C, Krasemann S, Glatzel M.

J Neurochem. 2016 Apr;137(1):88-100. doi: 10.1111/jnc.13514. Epub 2016 Mar 2.

6.

Regulation of Amyloid β Oligomer Binding to Neurons and Neurotoxicity by the Prion Protein-mGluR5 Complex.

Beraldo FH, Ostapchenko VG, Caetano FA, Guimaraes AL, Ferretti GD, Daude N, Bertram L, Nogueira KO, Silva JL, Westaway D, Cashman NR, Martins VR, Prado VF, Prado MA.

J Biol Chem. 2016 Oct 14;291(42):21945-21955. Epub 2016 Aug 25.

7.

The cellular prion protein traps Alzheimer's Aβ in an oligomeric form and disassembles amyloid fibers.

Younan ND, Sarell CJ, Davies P, Brown DR, Viles JH.

FASEB J. 2013 May;27(5):1847-58. doi: 10.1096/fj.12-222588. Epub 2013 Jan 18.

8.

Cellular prion protein is essential for oligomeric amyloid-β-induced neuronal cell death.

Kudo W, Lee HP, Zou WQ, Wang X, Perry G, Zhu X, Smith MA, Petersen RB, Lee HG.

Hum Mol Genet. 2012 Mar 1;21(5):1138-44. doi: 10.1093/hmg/ddr542. Epub 2011 Nov 18.

9.
10.

Is PrP the road to ruin?

Barton KA, Caughey B.

EMBO J. 2011 May 18;30(10):1882-4. doi: 10.1038/emboj.2011.129. Review. No abstract available.

11.

DNA converts cellular prion protein into the beta-sheet conformation and inhibits prion peptide aggregation.

Cordeiro Y, Machado F, Juliano L, Juliano MA, Brentani RR, Foguel D, Silva JL.

J Biol Chem. 2001 Dec 28;276(52):49400-9. Epub 2001 Oct 16.

12.

The N-terminal, polybasic region of PrP(C) dictates the efficiency of prion propagation by binding to PrP(Sc).

Turnbaugh JA, Unterberger U, Saá P, Massignan T, Fluharty BR, Bowman FP, Miller MB, Supattapone S, Biasini E, Harris DA.

J Neurosci. 2012 Jun 27;32(26):8817-30. doi: 10.1523/JNEUROSCI.1103-12.2012.

13.

Roles of endoproteolytic α-cleavage and shedding of the prion protein in neurodegeneration.

Altmeppen HC, Prox J, Puig B, Dohler F, Falker C, Krasemann S, Glatzel M.

FEBS J. 2013 Sep;280(18):4338-47. doi: 10.1111/febs.12196. Epub 2013 Mar 13. Review.

14.

Interaction between misfolded PrP and the ubiquitin-proteasome system in prion-mediated neurodegeneration.

Lin Z, Zhao D, Yang L.

Acta Biochim Biophys Sin (Shanghai). 2013 Jun;45(6):477-84. doi: 10.1093/abbs/gmt020. Epub 2013 Feb 28. Review.

PMID:
23449072
15.

The P's and Q's of cellular PrP-Aβ interactions.

Westaway D, Jhamandas JH.

Prion. 2012 Sep-Oct;6(4):359-63. doi: 10.4161/pri.20675. Epub 2012 Aug 9.

16.

N-terminal domain of prion protein directs its oligomeric association.

Trevitt CR, Hosszu LL, Batchelor M, Panico S, Terry C, Nicoll AJ, Risse E, Taylor WA, Sandberg MK, Al-Doujaily H, Linehan JM, Saibil HR, Scott DJ, Collinge J, Waltho JP, Clarke AR.

J Biol Chem. 2014 Sep 12;289(37):25497-508. doi: 10.1074/jbc.M114.566588. Epub 2014 Jul 29.

17.

Cellular prion protein targets amyloid-β fibril ends via its C-terminal domain to prevent elongation.

Bove-Fenderson E, Urano R, Straub JE, Harris DA.

J Biol Chem. 2017 Oct 13;292(41):16858-16871. doi: 10.1074/jbc.M117.789990. Epub 2017 Aug 23.

PMID:
28842494
18.

A cationic tetrapyrrole inhibits toxic activities of the cellular prion protein.

Massignan T, Cimini S, Stincardini C, Cerovic M, Vanni I, Elezgarai SR, Moreno J, Stravalaci M, Negro A, Sangiovanni V, Restelli E, Riccardi G, Gobbi M, Castilla J, Borsello T, Nonno R, Biasini E.

Sci Rep. 2016 Mar 15;6:23180. doi: 10.1038/srep23180.

19.

Prion peptide 106-126 as a model for prion replication and neurotoxicity.

Singh N, Gu Y, Bose S, Kalepu S, Mishra RS, Verghese S.

Front Biosci. 2002 Apr 1;7:a60-71.

PMID:
11897566
20.

Local structural plasticity of the prion protein. Analysis of NMR relaxation dynamics.

Viles JH, Donne D, Kroon G, Prusiner SB, Cohen FE, Dyson HJ, Wright PE.

Biochemistry. 2001 Mar 6;40(9):2743-53.

PMID:
11258885

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