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Items: 1 to 20 of 129

1.

In vitro primary human and animal cell-based blood-brain barrier models as a screening tool in drug discovery.

Lacombe O, Videau O, Chevillon D, Guyot AC, Contreras C, Blondel S, Nicolas L, Ghettas A, Bénech H, Thevenot E, Pruvost A, Bolze S, Krzaczkowski L, Prévost C, Mabondzo A.

Mol Pharm. 2011 Jun 6;8(3):651-63. doi: 10.1021/mp1004614. Epub 2011 Apr 15.

PMID:
21438632
2.

A new blood-brain barrier model using primary rat brain endothelial cells, pericytes and astrocytes.

Nakagawa S, Deli MA, Kawaguchi H, Shimizudani T, Shimono T, Kittel A, Tanaka K, Niwa M.

Neurochem Int. 2009 Mar-Apr;54(3-4):253-63. doi: 10.1016/j.neuint.2008.12.002. Epub 2008 Dec 7.

PMID:
19111869
3.

Murine in vitro model of the blood-brain barrier for evaluating drug transport.

Shayan G, Choi YS, Shusta EV, Shuler ML, Lee KH.

Eur J Pharm Sci. 2011 Jan 18;42(1-2):148-55. doi: 10.1016/j.ejps.2010.11.005. Epub 2010 Nov 13.

PMID:
21078386
4.

In vitro models for the blood-brain barrier.

Garberg P, Ball M, Borg N, Cecchelli R, Fenart L, Hurst RD, Lindmark T, Mabondzo A, Nilsson JE, Raub TJ, Stanimirovic D, Terasaki T, Oberg JO, Osterberg T.

Toxicol In Vitro. 2005 Apr;19(3):299-334.

PMID:
15713540
5.

Case study: adapting in vitro blood-brain barrier models for use in early-stage drug discovery.

Vandenhaute E, Sevin E, Hallier-Vanuxeem D, Dehouck MP, Cecchelli R.

Drug Discov Today. 2012 Apr;17(7-8):285-90. doi: 10.1016/j.drudis.2011.10.006. Epub 2011 Oct 20.

PMID:
22033197
6.

In vitro models of the blood-brain barrier.

Wilhelm I, Fazakas C, Krizbai IA.

Acta Neurobiol Exp (Wars). 2011;71(1):113-28. Review.

7.

Nicotine and cotinine increases the brain penetration of saquinavir in rat.

Manda VK, Mittapalli RK, Bohn KA, Adkins CE, Lockman PR.

J Neurochem. 2010 Dec;115(6):1495-507. doi: 10.1111/j.1471-4159.2010.07054.x. Epub 2010 Nov 11.

8.

How well can in vitro brain microcapillary endothelial cell models predict rodent in vivo blood-brain barrier permeability?

Avdeef A.

Eur J Pharm Sci. 2011 Jun 14;43(3):109-24. doi: 10.1016/j.ejps.2011.04.001. Epub 2011 Apr 14.

PMID:
21514381
9.

Progress in brain penetration evaluation in drug discovery and development.

Liu X, Chen C, Smith BJ.

J Pharmacol Exp Ther. 2008 May;325(2):349-56. doi: 10.1124/jpet.107.130294. Epub 2008 Jan 18. Review.

10.

A co-culture-based model of human blood-brain barrier: application to active transport of indinavir and in vivo-in vitro correlation.

Megard I, Garrigues A, Orlowski S, Jorajuria S, Clayette P, Ezan E, Mabondzo A.

Brain Res. 2002 Feb 15;927(2):153-67.

PMID:
11821009
11.

Patented in vitro blood-brain barrier models in CNS drug discovery.

Tóth A, Veszelka S, Nakagawa S, Niwa M, Deli MA.

Recent Pat CNS Drug Discov. 2011 May 1;6(2):107-18. Review.

PMID:
21585327
12.

Evaluation of the immortalized human brain capillary endothelial cell line BB19 as a human cell culture model for the blood-brain barrier.

Kusch-Poddar M, Drewe J, Fux I, Gutmann H.

Brain Res. 2005 Dec 7;1064(1-2):21-31. Epub 2005 Nov 14.

PMID:
16289483
13.

In vitro porcine blood-brain barrier model for permeability studies: pCEL-X software pKa(FLUX) method for aqueous boundary layer correction and detailed data analysis.

Yusof SR, Avdeef A, Abbott NJ.

Eur J Pharm Sci. 2014 Dec 18;65:98-111. doi: 10.1016/j.ejps.2014.09.009. Epub 2014 Sep 18.

14.

Blood-brain barrier in vitro models as tools in drug discovery: assessment of the transport ranking of antihistaminic drugs.

Neuhaus W, Mandikova J, Pawlowitsch R, Linz B, Bennani-Baiti B, Lauer R, Lachmann B, Noe CR.

Pharmazie. 2012 May;67(5):432-9.

PMID:
22764578
15.

Porcine brain microvessel endothelial cells as an in vitro model to predict in vivo blood-brain barrier permeability.

Zhang Y, Li CS, Ye Y, Johnson K, Poe J, Johnson S, Bobrowski W, Garrido R, Madhu C.

Drug Metab Dispos. 2006 Nov;34(11):1935-43. Epub 2006 Aug 8.

16.

Assays to predict drug permeation across the blood-brain barrier, and distribution to brain.

Abbott NJ, Dolman DE, Patabendige AK.

Curr Drug Metab. 2008 Nov;9(9):901-10. Review.

PMID:
18991587
17.

Barrier functionality and transport machineries of human ECV304 cells.

Barar J, Gumbleton M, Asadi M, Omidi Y.

Med Sci Monit. 2010 Jan;16(1):BR52-60.

PMID:
20037486
18.

Primary porcine brain microvascular endothelial cells: biochemical and functional characterisation as a model for drug transport and targeting.

Smith M, Omidi Y, Gumbleton M.

J Drug Target. 2007 May;15(4):253-68. Erratum in: J Drug Target. 2007 Jul;15(6):454.

PMID:
17487694
19.

Closing the gap between the in-vivo and in-vitro blood-brain barrier tightness.

Cohen-Kashi Malina K, Cooper I, Teichberg VI.

Brain Res. 2009 Aug 11;1284:12-21. doi: 10.1016/j.brainres.2009.05.072. Epub 2009 Jun 6.

PMID:
19501061
20.

Blood-brain barrier models: in vitro to in vivo translation in preclinical development of CNS-targeting biotherapeutics.

Stanimirovic DB, Bani-Yaghoub M, Perkins M, Haqqani AS.

Expert Opin Drug Discov. 2015 Feb;10(2):141-55. doi: 10.1517/17460441.2015.974545. Epub 2014 Nov 12. Review.

PMID:
25388782

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