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Items: 1 to 20 of 131


Modification of Akt2 by 4-hydroxynonenal inhibits insulin-dependent Akt signaling in HepG2 cells.

Shearn CT, Fritz KS, Reigan P, Petersen DR.

Biochemistry. 2011 May 17;50(19):3984-96. doi: 10.1021/bi200029w. Epub 2011 Apr 20.


Identification of 5' AMP-activated kinase as a target of reactive aldehydes during chronic ingestion of high concentrations of ethanol.

Shearn CT, Backos DS, Orlicky DJ, Smathers-McCullough RL, Petersen DR.

J Biol Chem. 2014 May 30;289(22):15449-62. doi: 10.1074/jbc.M113.543942. Epub 2014 Apr 10.


Phosphatase and tensin homolog deleted on chromosome 10 (PTEN) inhibition by 4-hydroxynonenal leads to increased Akt activation in hepatocytes.

Shearn CT, Smathers RL, Stewart BJ, Fritz KS, Galligan JJ, Hail N Jr, Petersen DR.

Mol Pharmacol. 2011 Jun;79(6):941-52. doi: 10.1124/mol.110.069534. Epub 2011 Mar 17.


Increased carbonylation of the lipid phosphatase PTEN contributes to Akt2 activation in a murine model of early alcohol-induced steatosis.

Shearn CT, Smathers RL, Backos DS, Reigan P, Orlicky DJ, Petersen DR.

Free Radic Biol Med. 2013 Dec;65:680-92. doi: 10.1016/j.freeradbiomed.2013.07.011. Epub 2013 Jul 17.


Regulation of glycogen synthase kinase-3beta by products of lipid peroxidation in human neuroblastoma cells.

Dozza B, Smith MA, Perry G, Tabaton M, Strocchi P.

J Neurochem. 2004 Jun;89(5):1224-32.


PTEN, Akt, and GSK3beta signalling in rat primary cortical neuronal cultures following tumor necrosis factor-alpha and trans-4-hydroxy-2-nonenal treatments.

Rickle A, Behbahani H, Ankarcrona M, Winblad B, Cowburn RF.

J Neurosci Res. 2006 Aug 15;84(3):596-605.


Development of Akt-activated GSK3β inhibitory peptide.

Kim JS, Piao S, Lee E, Yoon BY, Moon HR, Lee J, Jung Y, Ha NC.

Biochem Biophys Res Commun. 2013 May 17;434(4):735-9. doi: 10.1016/j.bbrc.2013.03.103. Epub 2013 Apr 10.


PCBP2 regulates hepatic insulin sensitivity via HIF-1α and STAT3 pathway in HepG2 cells.

Xia N, Tang Z, Wang C, Xu G, Nie X, Zhang W, Zhao Y, Wang S, Zhu X, Cui S.

Biochem Biophys Res Commun. 2015 Jul 17-24;463(1-2):116-22. doi: 10.1016/j.bbrc.2015.04.150. Epub 2015 May 19.


Resistin disrupts glycogen synthesis under high insulin and high glucose levels by down-regulating the hepatic levels of GSK3β.

Song R, Wang X, Mao Y, Li H, Li Z, Xu W, Wang R, Guo T, Jin L, Zhang X, Zhang Y, Zhou N, Hu R, Jia J, Lei Z, Irwin DM, Niu G, Tan H.

Gene. 2013 Oct 15;529(1):50-6. doi: 10.1016/j.gene.2013.06.085. Epub 2013 Jul 13.


FALDH reverses the deleterious action of oxidative stress induced by lipid peroxidation product 4-hydroxynonenal on insulin signaling in 3T3-L1 adipocytes.

Demozay D, Mas JC, Rocchi S, Van Obberghen E.

Diabetes. 2008 May;57(5):1216-26. doi: 10.2337/db07-0389. Epub 2008 Jan 3.


Strain-induced proliferation requires the phosphatidylinositol 3-kinase/AKT/glycogen synthase kinase pathway.

Gayer CP, Chaturvedi LS, Wang S, Craig DH, Flanigan T, Basson MD.

J Biol Chem. 2009 Jan 23;284(4):2001-11. doi: 10.1074/jbc.M804576200. Epub 2008 Dec 1.


In vivo and in vitro application of black soybean peptides in the amelioration of endoplasmic reticulum stress and improvement of insulin resistance.

Jang EH, Ko JH, Ahn CW, Lee HH, Shin JK, Chang SJ, Park CS, Kang JH.

Life Sci. 2010 Feb 13;86(7-8):267-74. doi: 10.1016/j.lfs.2009.12.012. Epub 2010 Jan 4.


Impact of lipid phosphatases SHIP2 and PTEN on the time- and Akt-isoform-specific amelioration of TNF-alpha-induced insulin resistance in 3T3-L1 adipocytes.

Ikubo M, Wada T, Fukui K, Ishiki M, Ishihara H, Asano T, Tsuneki H, Sasaoka T.

Am J Physiol Endocrinol Metab. 2009 Jan;296(1):E157-64. doi: 10.1152/ajpendo.90581.2008. Epub 2008 Nov 11.


Casein glycomacropeptide-derived peptide IPPKKNQDKTE ameliorates high glucose-induced insulin resistance in HepG2 cells via activation of AMPK signaling.

Song JJ, Wang Q, Du M, Li TG, Chen B, Mao XY.

Mol Nutr Food Res. 2017 Feb;61(2). doi: 10.1002/mnfr.201600301. Epub 2016 Sep 12.


Protein phosphatase 2A-linked and -unlinked caspase-dependent pathways for downregulation of Akt kinase triggered by 4-hydroxynonenal.

Liu W, Akhand AA, Takeda K, Kawamoto Y, Itoigawa M, Kato M, Suzuki H, Ishikawa N, Nakashima I.

Cell Death Differ. 2003 Jul;10(7):772-81.


Identification of Akt-independent regulation of hepatic lipogenesis by mammalian target of rapamycin (mTOR) complex 2.

Yuan M, Pino E, Wu L, Kacergis M, Soukas AA.

J Biol Chem. 2012 Aug 24;287(35):29579-88. doi: 10.1074/jbc.M112.386854. Epub 2012 Jul 7.

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