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Cationic contrast agents improve quantification of glycosaminoglycan (GAG) content by contrast enhanced CT imaging of cartilage.

Bansal PN, Joshi NS, Entezari V, Malone BC, Stewart RC, Snyder BD, Grinstaff MW.

J Orthop Res. 2011 May;29(5):704-9. doi: 10.1002/jor.21312. Epub 2010 Dec 23.


Contrast enhanced computed tomography can predict the glycosaminoglycan content and biomechanical properties of articular cartilage.

Bansal PN, Joshi NS, Entezari V, Grinstaff MW, Snyder BD.

Osteoarthritis Cartilage. 2010 Feb;18(2):184-91. doi: 10.1016/j.joca.2009.09.003. Epub 2009 Sep 25.


Contrast agent electrostatic attraction rather than repulsion to glycosaminoglycans affords a greater contrast uptake ratio and improved quantitative CT imaging in cartilage.

Bansal PN, Stewart RC, Entezari V, Snyder BD, Grinstaff MW.

Osteoarthritis Cartilage. 2011 Aug;19(8):970-6. doi: 10.1016/j.joca.2011.04.004. Epub 2011 Apr 21.


Contrast-enhanced CT with a high-affinity cationic contrast agent for imaging ex vivo bovine, intact ex vivo rabbit, and in vivo rabbit cartilage.

Stewart RC, Bansal PN, Entezari V, Lusic H, Nazarian RM, Snyder BD, Grinstaff MW.

Radiology. 2013 Jan;266(1):141-50. doi: 10.1148/radiol.12112246. Epub 2012 Nov 28.


Contrast-enhanced CT using a cationic contrast agent enables non-destructive assessment of the biochemical and biomechanical properties of mouse tibial plateau cartilage.

Lakin BA, Patel H, Holland C, Freedman JD, Shelofsky JS, Snyder BD, Stok KS, Grinstaff MW.

J Orthop Res. 2016 Jul;34(7):1130-8. doi: 10.1002/jor.23141. Epub 2016 Jan 6.


Contrast-enhanced CT of articular cartilage: experimental study for quantification of glycosaminoglycan content in articular cartilage.

Yoo HJ, Hong SH, Choi JY, Lee IJ, Kim SJ, Choi JA, Kang HS.

Radiology. 2011 Dec;261(3):805-12. doi: 10.1148/radiol.11102495. Epub 2011 Sep 21.


Cationic agent contrast-enhanced computed tomography imaging of cartilage correlates with the compressive modulus and coefficient of friction.

Lakin BA, Grasso DJ, Shah SS, Stewart RC, Bansal PN, Freedman JD, Grinstaff MW, Snyder BD.

Osteoarthritis Cartilage. 2013 Jan;21(1):60-8. doi: 10.1016/j.joca.2012.09.007. Epub 2012 Oct 4.


Effect of mechanical convection on the partitioning of an anionic iodinated contrast agent in intact patellar cartilage.

Entezari V, Bansal PN, Stewart RC, Lakin BA, Grinstaff MW, Snyder BD.

J Orthop Res. 2014 Oct;32(10):1333-40. doi: 10.1002/jor.22662. Epub 2014 Jun 24.


Formalin fixation affects equilibrium partitioning of an ionic contrast agent-microcomputed tomography (EPIC-μCT) imaging of osteochondral samples.

Benders KE, Malda J, Saris DB, Dhert WJ, Steck R, Hutmacher DW, Klein TJ.

Osteoarthritis Cartilage. 2010 Dec;18(12):1586-91. doi: 10.1016/j.joca.2010.10.005. Epub 2010 Oct 13.


Effect of contrast agent charge on visualization of articular cartilage using computed tomography: exploiting electrostatic interactions for improved sensitivity.

Joshi NS, Bansal PN, Stewart RC, Snyder BD, Grinstaff MW.

J Am Chem Soc. 2009 Sep 23;131(37):13234-5. doi: 10.1021/ja9053306.


pQCT study on diffusion and equilibrium distribution of iodinated anionic contrast agent in human articular cartilage--associations to matrix composition and integrity.

Silvast TS, Jurvelin JS, Lammi MJ, Töyräs J.

Osteoarthritis Cartilage. 2009 Jan;17(1):26-32. doi: 10.1016/j.joca.2008.05.012. Epub 2008 Jul 7.


Clinically applied CT arthrography to measure the sulphated glycosaminoglycan content of cartilage.

Siebelt M, van Tiel J, Waarsing JH, Piscaer TM, van Straten M, Booij R, Dijkshoorn ML, Kleinrensink GJ, Verhaar JA, Krestin GP, Weinans H, Oei EH.

Osteoarthritis Cartilage. 2011 Oct;19(10):1183-9. doi: 10.1016/j.joca.2011.07.006. Epub 2011 Jul 23.


Quantitative imaging of excised osteoarthritic cartilage using spectral CT.

Rajendran K, Löbker C, Schon BS, Bateman CJ, Younis RA, de Ruiter NJ, Chernoglazov AI, Ramyar M, Hooper GJ, Butler AP, Woodfield TB, Anderson NG.

Eur Radiol. 2017 Jan;27(1):384-392. Epub 2016 May 10.


Contrast agent-enhanced computed tomography of articular cartilage: association with tissue composition and properties.

Silvast TS, Jurvelin JS, Aula AS, Lammi MJ, Töyräs J.

Acta Radiol. 2009 Jan;50(1):78-85. doi: 10.1080/02841850802572526.


Correlations between X-ray attenuation and GAG content of different cartilage layers based on contrast agent enhanced Micro-CT.

Fan F, Xiaofei L, Pengling R, Xiran C, Yan Y, Yubo F, Haijun N.

Conf Proc IEEE Eng Med Biol Soc. 2015;2015:6366-9. doi: 10.1109/EMBC.2015.7319849.


Contrast-enhanced CT facilitates rapid, non-destructive assessment of cartilage and bone properties of the human metacarpal.

Lakin BA, Ellis DJ, Shelofsky JS, Freedman JD, Grinstaff MW, Snyder BD.

Osteoarthritis Cartilage. 2015 Dec;23(12):2158-2166. doi: 10.1016/j.joca.2015.05.033. Epub 2015 Jun 9.


Contrast enhanced CT attenuation correlates with the GAG content of bovine meniscus.

Lakin BA, Grasso DJ, Stewart RC, Freedman JD, Snyder BD, Grinstaff MW.

J Orthop Res. 2013 Nov;31(11):1765-71. doi: 10.1002/jor.22421. Epub 2013 Jul 5.


Synthesis and Preclinical Characterization of a Cationic Iodinated Imaging Contrast Agent (CA4+) and Its Use for Quantitative Computed Tomography of Ex Vivo Human Hip Cartilage.

Stewart RC, Patwa AN, Lusic H, Freedman JD, Wathier M, Snyder BD, Guermazi A, Grinstaff MW.

J Med Chem. 2017 Jul 13;60(13):5543-5555. doi: 10.1021/acs.jmedchem.7b00234. Epub 2017 Jun 27.


Diffusion of Gd-DTPA²⁻ into articular cartilage.

Salo EN, Nissi MJ, Kulmala KA, Tiitu V, Töyräs J, Nieminen MT.

Osteoarthritis Cartilage. 2012 Feb;20(2):117-26. doi: 10.1016/j.joca.2011.11.016. Epub 2011 Dec 2.


Topographical mapping of biochemical properties of articular cartilage in the equine fetlock joint.

Brama PA, Tekoppele JM, Bank RA, Karssenberg D, Barneveld A, van Weeren PR.

Equine Vet J. 2000 Jan;32(1):19-26.


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