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Items: 1 to 20 of 95


Silencing of microRNA families by seed-targeting tiny LNAs.

Obad S, dos Santos CO, Petri A, Heidenblad M, Broom O, Ruse C, Fu C, Lindow M, Stenvang J, Straarup EM, Hansen HF, Koch T, Pappin D, Hannon GJ, Kauppinen S.

Nat Genet. 2011 Mar 20;43(4):371-8. doi: 10.1038/ng.786.


Antagonism of microRNA-122 in mice by systemically administered LNA-antimiR leads to up-regulation of a large set of predicted target mRNAs in the liver.

Elmén J, Lindow M, Silahtaroglu A, Bak M, Christensen M, Lind-Thomsen A, Hedtjärn M, Hansen JB, Hansen HF, Straarup EM, McCullagh K, Kearney P, Kauppinen S.

Nucleic Acids Res. 2008 Mar;36(4):1153-62. Epub 2007 Dec 23.


Pharmacological inhibition of a microRNA family in nonhuman primates by a seed-targeting 8-mer antimiR.

Rottiers V, Obad S, Petri A, McGarrah R, Lindholm MW, Black JC, Sinha S, Goody RJ, Lawrence MS, deLemos AS, Hansen HF, Whittaker S, Henry S, Brookes R, Najafi-Shoushtari SH, Chung RT, Whetstine JR, Gerszten RE, Kauppinen S, Näär AM.

Sci Transl Med. 2013 Nov 20;5(212):212ra162. doi: 10.1126/scitranslmed.3006840.


LNA-mediated microRNA silencing in non-human primates.

Elmén J, Lindow M, Schütz S, Lawrence M, Petri A, Obad S, Lindholm M, Hedtjärn M, Hansen HF, Berger U, Gullans S, Kearney P, Sarnow P, Straarup EM, Kauppinen S.

Nature. 2008 Apr 17;452(7189):896-9. doi: 10.1038/nature06783. Epub 2008 Mar 26.


Inhibition of Gastric Tumor Cell Growth Using Seed-targeting LNA as Specific, Long-lasting MicroRNA Inhibitors.

Staedel C, Varon C, Nguyen PH, Vialet B, Chambonnier L, Rousseau B, Soubeyran I, Evrard S, Couillaud F, Darfeuille F.

Mol Ther Nucleic Acids. 2015 Jul 7;4:e246. doi: 10.1038/mtna.2015.18.


Silencing of the miR-17~92 cluster family inhibits medulloblastoma progression.

Murphy BL, Obad S, Bihannic L, Ayrault O, Zindy F, Kauppinen S, Roussel MF.

Cancer Res. 2013 Dec 1;73(23):7068-78. doi: 10.1158/0008-5472.CAN-13-0927. Epub 2013 Oct 21.


Targeting of microRNAs for therapeutics.

Stenvang J, Lindow M, Kauppinen S.

Biochem Soc Trans. 2008 Dec;36(Pt 6):1197-200. doi: 10.1042/BST0361197.


Efficient and specific inhibition of plant microRNA function by anti-microRNA oligonucleotides (AMOs) in vitro and in vivo.

He L, Xie M, Huang J, Zhang T, Shi S, Tang T.

Plant Cell Rep. 2016 Apr;35(4):933-45. doi: 10.1007/s00299-016-1933-y. Epub 2016 Jan 20.


PEI-complexed LNA antiseeds as miRNA inhibitors.

Thomas M, Lange-Grünweller K, Dayyoub E, Bakowsky U, Weirauch U, Aigner A, Hartmann RK, Grünweller A.

RNA Biol. 2012 Aug;9(8):1088-98. doi: 10.4161/rna.21165. Epub 2012 Aug 1.


A direct comparison of anti-microRNA oligonucleotide potency.

Lennox KA, Behlke MA.

Pharm Res. 2010 Sep;27(9):1788-99. doi: 10.1007/s11095-010-0156-0. Epub 2010 Apr 28.


Therapeutic inhibition of the miR-34 family attenuates pathological cardiac remodeling and improves heart function.

Bernardo BC, Gao XM, Winbanks CE, Boey EJ, Tham YK, Kiriazis H, Gregorevic P, Obad S, Kauppinen S, Du XJ, Lin RC, McMullen JR.

Proc Natl Acad Sci U S A. 2012 Oct 23;109(43):17615-20. doi: 10.1073/pnas.1206432109. Epub 2012 Oct 9.


Inhibiting gene expression with locked nucleic acids (LNAs) that target chromosomal DNA.

Beane RL, Ram R, Gabillet S, Arar K, Monia BP, Corey DR.

Biochemistry. 2007 Jun 26;46(25):7572-80. Epub 2007 May 31.


Interfering nanoparticles for silencing microRNAs.

Baigude H, Rana TM.

Methods Enzymol. 2012;509:339-53. doi: 10.1016/B978-0-12-391858-1.00017-4.


Silencing of microRNAs in vivo with 'antagomirs'.

Krützfeldt J, Rajewsky N, Braich R, Rajeev KG, Tuschl T, Manoharan M, Stoffel M.

Nature. 2005 Dec 1;438(7068):685-9. Epub 2005 Oct 30.


Long-term ex vivo monitoring of in vivo microRNA activity in liver using a secreted luciferase sensor.

Wang G, Dong X, Hu J, Tian W, Yuchi J, Wang Y, Wu X.

Sci China Life Sci. 2011 May;54(5):418-25. doi: 10.1007/s11427-011-4171-0. Epub 2011 May 15.


Systematic identification of mRNAs recruited to argonaute 2 by specific microRNAs and corresponding changes in transcript abundance.

Hendrickson DG, Hogan DJ, Herschlag D, Ferrell JE, Brown PO.

PLoS One. 2008 May 7;3(5):e2126. doi: 10.1371/journal.pone.0002126. Erratum in: PLoS ONE. 2008;3(11)


Silencing of miR-21 by locked nucleic acid-lipid nanocapsule complexes sensitize human glioblastoma cells to radiation-induced cell death.

Griveau A, Bejaud J, Anthiya S, Avril S, Autret D, Garcion E.

Int J Pharm. 2013 Oct 1;454(2):765-74. doi: 10.1016/j.ijpharm.2013.05.049. Epub 2013 May 31.


In vitro optimization of 2'-OMe-4'-thioribonucleoside-modified anti-microRNA oligonucleotides and its targeting delivery to mouse liver using a liposomal nanoparticle.

Takahashi M, Yamada N, Hatakeyama H, Murata M, Sato Y, Minakawa N, Harashima H, Matsuda A.

Nucleic Acids Res. 2013 Dec;41(22):10659-67. doi: 10.1093/nar/gkt823. Epub 2013 Sep 11.


Silencing of microRNA-21 in vivo ameliorates autoimmune splenomegaly in lupus mice.

Garchow BG, Bartulos Encinas O, Leung YT, Tsao PY, Eisenberg RA, Caricchio R, Obad S, Petri A, Kauppinen S, Kiriakidou M.

EMBO Mol Med. 2011 Oct;3(10):605-15. doi: 10.1002/emmm.201100171. Epub 2011 Sep 1.


Properties of N(4)-methylated cytidines in miRNA mimics.

Guennewig B, Stoltz M, Menzi M, Dogar AM, Hall J.

Nucleic Acid Ther. 2012 Apr;22(2):109-16. doi: 10.1089/nat.2011.0329. Epub 2012 Feb 28.


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