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Items: 1 to 20 of 101

1.

Probing the determinants of diacylglycerol binding affinity in the C1B domain of protein kinase Cα.

Stewart MD, Morgan B, Massi F, Igumenova TI.

J Mol Biol. 2011 May 20;408(5):949-70. doi: 10.1016/j.jmb.2011.03.020. Epub 2011 Mar 17.

2.

Interfacial partitioning of a loop hinge residue contributes to diacylglycerol affinity of conserved region 1 domains.

Stewart MD, Cole TR, Igumenova TI.

J Biol Chem. 2014 Oct 3;289(40):27653-64. doi: 10.1074/jbc.M114.585570. Epub 2014 Aug 14.

3.

Intramolecular occlusion of the diacylglycerol-binding site in the C1 domain of munc13-1.

Shen N, Guryev O, Rizo J.

Biochemistry. 2005 Feb 1;44(4):1089-96.

PMID:
15667202
4.

Modeling studies on the structural determinants for the DAG/phorbol ester binding to C1 domain.

Rahman GM, Das J.

J Biomol Struct Dyn. 2015;33(1):219-32. doi: 10.1080/07391102.2014.895679. Epub 2014 Mar 25.

PMID:
24666138
5.

Selective binding of phorbol esters and diacylglycerol by individual C1 domains of the PKD family.

Chen J, Deng F, Li J, Wang QJ.

Biochem J. 2008 Apr 15;411(2):333-42.

PMID:
18076381
6.

C1 domains exposed: from diacylglycerol binding to protein-protein interactions.

Colón-González F, Kazanietz MG.

Biochim Biophys Acta. 2006 Aug;1761(8):827-37. Epub 2006 May 13. Review.

PMID:
16861033
7.

Activation mechanisms of conventional protein kinase C isoforms are determined by the ligand affinity and conformational flexibility of their C1 domains.

Ananthanarayanan B, Stahelin RV, Digman MA, Cho W.

J Biol Chem. 2003 Nov 21;278(47):46886-94. Epub 2003 Sep 3.

8.

Conformationally constrained analogues of diacylglycerol (DAG). 28. DAG-dioxolanones reveal a new additional interaction site in the C1b domain of PKC delta.

Choi Y, Pu Y, Peach ML, Kang JH, Lewin NE, Sigano DM, Garfield SH, Blumberg PM, Marquez VE.

J Med Chem. 2007 Jul 26;50(15):3465-81. Epub 2007 Jun 26.

PMID:
17591763
9.

Differential membrane binding and diacylglycerol recognition by C1 domains of RasGRPs.

Johnson JE, Goulding RE, Ding Z, Partovi A, Anthony KV, Beaulieu N, Tazmini G, Cornell RB, Kay RJ.

Biochem J. 2007 Sep 1;406(2):223-36.

10.

A single residue in the C1 domain sensitizes novel protein kinase C isoforms to cellular diacylglycerol production.

Dries DR, Gallegos LL, Newton AC.

J Biol Chem. 2007 Jan 12;282(2):826-30. Epub 2006 Oct 27.

11.

Diacylglycerol-induced membrane targeting and activation of protein kinase Cepsilon: mechanistic differences between protein kinases Cdelta and Cepsilon.

Stahelin RV, Digman MA, Medkova M, Ananthanarayanan B, Melowic HR, Rafter JD, Cho W.

J Biol Chem. 2005 May 20;280(20):19784-93. Epub 2005 Mar 15.

12.

Mechanism of diacylglycerol-induced membrane targeting and activation of protein kinase Cdelta.

Stahelin RV, Digman MA, Medkova M, Ananthanarayanan B, Rafter JD, Melowic HR, Cho W.

J Biol Chem. 2004 Jul 9;279(28):29501-12. Epub 2004 Apr 22.

13.

The origin of C1A-C2 interdomain interactions in protein kinase Calpha.

Stahelin RV, Wang J, Blatner NR, Rafter JD, Murray D, Cho W.

J Biol Chem. 2005 Oct 28;280(43):36452-63. Epub 2005 Aug 3.

14.

beta2-chimaerin is a novel target for diacylglycerol: binding properties and changes in subcellular localization mediated by ligand binding to its C1 domain.

Caloca MJ, Garcia-Bermejo ML, Blumberg PM, Lewin NE, Kremmer E, Mischak H, Wang S, Nacro K, Bienfait B, Marquez VE, Kazanietz MG.

Proc Natl Acad Sci U S A. 1999 Oct 12;96(21):11854-9.

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17.

Conformationally constrained analogues of diacylglycerol (DAG). 16. How much structural complexity is necessary for recognition and high binding affinity to protein kinase C?

Nacro K, Bienfait B, Lee J, Han KC, Kang JH, Benzaria S, Lewin NE, Bhattacharyya DK, Blumberg PM, Marquez VE.

J Med Chem. 2000 Mar 9;43(5):921-44.

PMID:
10715158
18.
19.

Single-molecule studies reveal a hidden key step in the activation mechanism of membrane-bound protein kinase C-α.

Ziemba BP, Li J, Landgraf KE, Knight JD, Voth GA, Falke JJ.

Biochemistry. 2014 Mar 18;53(10):1697-713. doi: 10.1021/bi4016082. Epub 2014 Mar 7.

20.

Toggling of Diacylglycerol Affinity Correlates with Conformational Plasticity in C1 Domains.

Stewart MD, Igumenova TI.

Biochemistry. 2017 May 18. doi: 10.1021/acs.biochem.7b00228. [Epub ahead of print]

PMID:
28505428

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