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Targeted reduction of advanced glycation improves renal function in obesity.

Harcourt BE, Sourris KC, Coughlan MT, Walker KZ, Dougherty SL, Andrikopoulos S, Morley AL, Thallas-Bonke V, Chand V, Penfold SA, de Courten MP, Thomas MC, Kingwell BA, Bierhaus A, Cooper ME, de Courten B, Forbes JM.

Kidney Int. 2011 Jul;80(2):190-8. doi: 10.1038/ki.2011.57. Epub 2011 Mar 16.


Disparate effects on renal and oxidative parameters following RAGE deletion, AGE accumulation inhibition, or dietary AGE control in experimental diabetic nephropathy.

Tan AL, Sourris KC, Harcourt BE, Thallas-Bonke V, Penfold S, Andrikopoulos S, Thomas MC, O'Brien RC, Bierhaus A, Cooper ME, Forbes JM, Coughlan MT.

Am J Physiol Renal Physiol. 2010 Mar;298(3):F763-70. doi: 10.1152/ajprenal.00591.2009. Epub 2009 Dec 16.


AGE-RAGE interaction and oxidative stress in obesity-related renal dysfunction.

Tomino Y, Hagiwara S, Gohda T.

Kidney Int. 2011 Jul;80(2):133-5. doi: 10.1038/ki.2011.86.


Targeting the AGE-RAGE axis improves renal function in the context of a healthy diet low in advanced glycation end-product content.

Thallas-Bonke V, Coughlan MT, Tan AL, Harcourt BE, Morgan PE, Davies MJ, Bach LA, Cooper ME, Forbes JM.

Nephrology (Carlton). 2013 Jan;18(1):47-56. doi: 10.1111/j.1440-1797.2012.01665.x.


Cardiac inflammation associated with a Western diet is mediated via activation of RAGE by AGEs.

Tikellis C, Thomas MC, Harcourt BE, Coughlan MT, Pete J, Bialkowski K, Tan A, Bierhaus A, Cooper ME, Forbes JM.

Am J Physiol Endocrinol Metab. 2008 Aug;295(2):E323-30. doi: 10.1152/ajpendo.00024.2008. Epub 2008 May 13.


Short-term effects of dietary advanced glycation end products in rats.

Poulsen MW, Andersen JM, Hedegaard RV, Madsen AN, Krath BN, Monošík R, Bak MJ, Nielsen J, Holst B, Skibsted LH, Larsen LH, Dragsted LO.

Br J Nutr. 2016 Feb 28;115(4):629-36. doi: 10.1017/S0007114515004833.


Identifying advanced glycation end products as a major source of oxidants in aging: implications for the management and/or prevention of reduced renal function in elderly persons.

Vlassara H, Uribarri J, Ferrucci L, Cai W, Torreggiani M, Post JB, Zheng F, Striker GE.

Semin Nephrol. 2009 Nov;29(6):594-603. doi: 10.1016/j.semnephrol.2009.07.013.


Dietary n-3 polyunsaturated fatty acids revert renal responses induced by a combination of 2 protocols that increase the amounts of advanced glycation end product in rats.

de Assis AM, Rech A, Longoni A, da Silva Morrone M, de Bittencourt Pasquali MA, Perry ML, Souza DO, Moreira JC.

Nutr Res. 2015 Jun;35(6):512-22. doi: 10.1016/j.nutres.2015.04.013. Epub 2015 Apr 25.


Alagebrium reduces glomerular fibrogenesis and inflammation beyond preventing RAGE activation in diabetic apolipoprotein E knockout mice.

Watson AM, Gray SP, Jiaze L, Soro-Paavonen A, Wong B, Cooper ME, Bierhaus A, Pickering R, Tikellis C, Tsorotes D, Thomas MC, Jandeleit-Dahm KA.

Diabetes. 2012 Aug;61(8):2105-13. doi: 10.2337/db11-1546. Epub 2012 Jun 14.


Contribution of dietary advanced glycation end products (AGE) to circulating AGE: role of dietary fat.

Davis KE, Prasad C, Vijayagopal P, Juma S, Adams-Huet B, Imrhan V.

Br J Nutr. 2015 Dec 14;114(11):1797-806. doi: 10.1017/S0007114515003487. Epub 2015 Sep 22.


Combination therapy with the advanced glycation end product cross-link breaker, alagebrium, and angiotensin converting enzyme inhibitors in diabetes: synergy or redundancy?

Coughlan MT, Thallas-Bonke V, Pete J, Long DM, Gasser A, Tong DC, Arnstein M, Thorpe SR, Cooper ME, Forbes JM.

Endocrinology. 2007 Feb;148(2):886-95. Epub 2006 Nov 16.


RAGE influences obesity in mice. Effects of the presence of RAGE on weight gain, AGE accumulation, and insulin levels in mice on a high fat diet.

Leuner B, Max M, Thamm K, Kausler C, Yakobus Y, Bierhaus A, Sel S, Hofmann B, Silber RE, Simm A, Nass N.

Z Gerontol Geriatr. 2012 Feb;45(2):102-8. doi: 10.1007/s00391-011-0279-x.


Restricted intake of dietary advanced glycation end products retards renal progression in the remnant kidney model.

Feng JX, Hou FF, Liang M, Wang GB, Zhang X, Li HY, Xie D, Tian JW, Liu ZQ.

Kidney Int. 2007 May;71(9):901-11.


The anti-inflammation effect of Moutan Cortex on advanced glycation end products-induced rat mesangial cells dysfunction and High-glucose-fat diet and streptozotocin-induced diabetic nephropathy rats.

Zhang MH, Feng L, Zhu MM, Gu JF, Jiang J, Cheng XD, Ding SM, Wu C, Jia XB.

J Ethnopharmacol. 2014;151(1):591-600. doi: 10.1016/j.jep.2013.11.015. Epub 2013 Nov 21.


Advanced lipoxidation end-products mediate lipid-induced glomerular injury: role of receptor-mediated mechanisms.

Iacobini C, Menini S, Ricci C, Scipioni A, Sansoni V, Mazzitelli G, Cordone S, Pesce C, Pugliese F, Pricci F, Pugliese G.

J Pathol. 2009 Jul;218(3):360-9. doi: 10.1002/path.2536.


Short-term low calorie diet intervention reduces serum advanced glycation end products in healthy overweight or obese adults.

Gugliucci A, Kotani K, Taing J, Matsuoka Y, Sano Y, Yoshimura M, Egawa K, Horikawa C, Kitagawa Y, Kiso Y, Kimura S, Sakane N.

Ann Nutr Metab. 2009;54(3):197-201. doi: 10.1159/000217817. Epub 2009 May 6.


Loganin attenuates diabetic nephropathy in C57BL/6J mice with diabetes induced by streptozotocin and fed with diets containing high level of advanced glycation end products.

Liu K, Xu H, Lv G, Liu B, Lee MK, Lu C, Lv X, Wu Y.

Life Sci. 2015 Feb 15;123:78-85. doi: 10.1016/j.lfs.2014.12.028. Epub 2015 Jan 23.


Long-term renal effects of a neutralizing RAGE antibody in obese type 2 diabetic mice.

Flyvbjerg A, Denner L, Schrijvers BF, Tilton RG, Mogensen TH, Paludan SR, Rasch R.

Diabetes. 2004 Jan;53(1):166-72.


Endothelial dysfunction in patients with chronic kidney disease results from advanced glycation end products (AGE)-mediated inhibition of endothelial nitric oxide synthase through RAGE activation.

Linden E, Cai W, He JC, Xue C, Li Z, Winston J, Vlassara H, Uribarri J.

Clin J Am Soc Nephrol. 2008 May;3(3):691-8. doi: 10.2215/CJN.04291007. Epub 2008 Feb 6.


Plasma advanced glycation end products are decreased in obese children compared with lean controls.

Sebeková K, Somoza V, Jarcusková M, Heidland A, Podracká L.

Int J Pediatr Obes. 2009;4(2):112-8. doi: 10.1080/17477160802248039.


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