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Distribution and progression of chondrocyte damage in a whole-organ model of human ankle intra-articular fracture.

Tochigi Y, Buckwalter JA, Martin JA, Hillis SL, Zhang P, Vaseenon T, Lehman AD, Brown TD.

J Bone Joint Surg Am. 2011 Mar 16;93(6):533-9. doi: 10.2106/JBJS.I.01777.


A novel impaction technique to create experimental articular fractures in large animal joints.

Tochigi Y, Zhang P, Rudert MJ, Baer TE, Martin JA, Hillis SL, Brown TD.

Osteoarthritis Cartilage. 2013 Jan;21(1):200-8. doi: 10.1016/j.joca.2012.10.004. Epub 2012 Oct 13.


Basic science of intra-articular fractures and posttraumatic osteoarthritis.

McKinley TO, Borrelli J Jr, D'Lima DD, Furman BD, Giannoudis PV.

J Orthop Trauma. 2010 Sep;24(9):567-70. doi: 10.1097/BOT.0b013e3181ed298d. Review.


A clinically realistic large animal model of intra-articular fracture that progresses to post-traumatic osteoarthritis.

Goetz JE, Fredericks D, Petersen E, Rudert MJ, Baer T, Swanson E, Roberts N, Martin J, Tochigi Y.

Osteoarthritis Cartilage. 2015 Oct;23(10):1797-805. doi: 10.1016/j.joca.2015.05.022. Epub 2015 May 29.


Osmolarity influences chondrocyte death in wounded articular cartilage.

Amin AK, Huntley JS, Bush PG, Simpson AH, Hall AC.

J Bone Joint Surg Am. 2008 Jul;90(7):1531-42. doi: 10.2106/JBJS.G.00857.


Acute joint pathology and synovial inflammation is associated with increased intra-articular fracture severity in the mouse knee.

Lewis JS, Hembree WC, Furman BD, Tippets L, Cattel D, Huebner JL, Little D, DeFrate LE, Kraus VB, Guilak F, Olson SA.

Osteoarthritis Cartilage. 2011 Jul;19(7):864-73. doi: 10.1016/j.joca.2011.04.011. Epub 2011 May 12.


Inflammatory Cytokines and Matrix Metalloproteinases in the Synovial Fluid After Intra-articular Ankle Fracture.

Adams SB, Setton LA, Bell RD, Easley ME, Huebner JL, Stabler T, Kraus VB, Leimer EM, Olson SA, Nettles DL.

Foot Ankle Int. 2015 Nov;36(11):1264-71. doi: 10.1177/1071100715611176. Epub 2015 Oct 8.


A rat model of chondrocyte death after closed intra-articular fracture.

Swart E, Konopka G, Gardner TR, O J, Greisberg J.

J Orthop Trauma. 2013 Mar;27(3):e50-6. doi: 10.1097/BOT.0b013e318251e66d.


Chondrocyte viability after intra-articular calcaneal fractures in humans.

Ball ST, Jadin K, Allen RT, Schwartz AK, Sah RL, Brage ME.

Foot Ankle Int. 2007 Jun;28(6):665-8.


Surgical treatment of tibial plafond fractures.

Stapleton JJ, Zgonis T.

Clin Podiatr Med Surg. 2014 Oct;31(4):547-64. doi: 10.1016/j.cpm.2014.06.002. Epub 2014 Aug 3. Review.


Effects of cartilage impact with and without fracture on chondrocyte viability and the release of inflammatory markers.

Stolberg-Stolberg JA, Furman BD, Garrigues NW, Lee J, Pisetsky DS, Stearns NA, DeFrate LE, Guilak F, Olson SA.

J Orthop Res. 2013 Aug;31(8):1283-92. doi: 10.1002/jor.22348. Epub 2013 Apr 25.


The death of articular chondrocytes after intra-articular fracture in humans.

Murray MM, Zurakowski D, Vrahas MS.

J Trauma. 2004 Jan;56(1):128-31.


Viability and volume of in situ bovine articular chondrocytes-changes following a single impact and effects of medium osmolarity.

Bush PG, Hodkinson PD, Hamilton GL, Hall AC.

Osteoarthritis Cartilage. 2005 Jan;13(1):54-65.


Nitric oxide-associated chondrocyte apoptosis in trauma patients after high-energy lower extremity intra-articular fractures.

Prince DE, Greisberg JK.

J Orthop Traumatol. 2015 Dec;16(4):335-41. doi: 10.1007/s10195-015-0350-2. Epub 2015 May 10.


Chondrocyte damage and contact pressures following impact on the rabbit tibiofemoral joint.

Isaac DI, Meyer EG, Haut RC.

J Biomech Eng. 2008 Aug;130(4):041018. doi: 10.1115/1.2948403.


Cartilage viability and catabolism in the intact porcine knee following transarticular impact loading with and without articular fracture.

Backus JD, Furman BD, Swimmer T, Kent CL, McNulty AL, Defrate LE, Guilak F, Olson SA.

J Orthop Res. 2011 Apr;29(4):501-10. doi: 10.1002/jor.21270. Epub 2010 Nov 4.


Progressive chondrocyte death after impact injury indicates a need for chondroprotective therapy.

Szczodry M, Coyle CH, Kramer SJ, Smolinski P, Chu CR.

Am J Sports Med. 2009 Dec;37(12):2318-22. doi: 10.1177/0363546509348840. Epub 2009 Oct 28.


Chondrocyte death in mechanically injured articular cartilage--the influence of extracellular calcium.

Amin AK, Huntley JS, Bush PG, Simpson AH, Hall AC.

J Orthop Res. 2009 Jun;27(6):778-84. doi: 10.1002/jor.20809.


Joint-dependent response to impact and implications for post-traumatic osteoarthritis.

Novakofski KD, Berg LC, Bronzini I, Bonnevie ED, Poland SG, Bonassar LJ, Fortier LA.

Osteoarthritis Cartilage. 2015 Jul;23(7):1130-7. doi: 10.1016/j.joca.2015.02.023. Epub 2015 Feb 26.


Rapid in situ chondrocyte death induced by Staphylococcus aureus toxins in a bovine cartilage explant model of septic arthritis.

Smith ID, Winstanley JP, Milto KM, Doherty CJ, Czarniak E, Amyes SG, Simpson AH, Hall AC.

Osteoarthritis Cartilage. 2013 Nov;21(11):1755-65. doi: 10.1016/j.joca.2013.07.013. Epub 2013 Jul 27.

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